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Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays pp 17–72Cite as

Central Nervous System (CNS) Safety Pharmacology Studies

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Abstract

This section describes basic protocols satisfying ICH S7A recommendations for core battery CNS studies. Included are protocols for measuring general behavioral signs induced by test substances (Irwin test), effects on spontaneous locomotion (activity meter test), effects on neuromuscular coordination (rotarod test), effects on the convulsive threshold (electroconvulsive shock (ECS) threshold and PTZ seizure tests), interaction with hypnotics (barbital interaction test), and effects on the pain threshold (hot plate test).

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Authors and Affiliations

  1. Porsolt SAS, 9bis rue Henri Martin, Boulogne-Billancourt, 92100, France

    Dr. Vincent Castagné, Christelle Froger-Colléaux, Elise Esneault, Hernier Anne Marie, Martine Lemaire & Dr. Roger D. Porsolt

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  1. Dr. Vincent Castagné
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  2. Christelle Froger-Colléaux
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  3. Elise Esneault
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  4. Hernier Anne Marie
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  5. Martine Lemaire
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  6. Dr. Roger D. Porsolt
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Correspondence to Vincent Castagné .

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Editors and Affiliations

  1. Sanofi Pharma Deutschland GmbH, A company of the Sanofi-Aventis Group Industriepark Hoechst, Frankfurt am Main, Germany

    Jochen Maas

  2. Dieburg, Germany

    Franz J. Hock

  3. Idstein, Germany

    Dieter Mayer

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Castagné, V., Froger-Colléaux, C., Esneault, E., Marie, H.A., Lemaire, M., Porsolt, R.D. (2013). Central Nervous System (CNS) Safety Pharmacology Studies. In: Vogel, H.G., Maas, J., Hock, F.J., Mayer, D. (eds) Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25240-2_3

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