Abstract
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Non-Hodgkin’s lymphoma (NHL) is a group of malignancies comprising many different types of lymphoma, and has historically been classified a variety of ways.
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Current classification schemes take into account the cells of origin for NHL. The clinically relevant classification schemes divide the diseases into indolent and aggressive NHL.
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Although systemic symptoms (fever, night sweats, weight loss, a.k.a. B symptoms) can occur, most symptoms vary, depending on the site involved.
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Important prognostic factors include age, stage, number of extranodal sites, performance status, and lactate dehydrogenase (LDH) level, which have all been incorporated into the widely used International Prognostic Index.
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Other important prognostic factors include tumor size, pathologic subtype, β2-microglobulin concentration, the presence of B symptoms, bone marrow involvement, response to treatment, and duration of remission.
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Treatment of NHL depends on the clinical classification of the tumor (indolent versus aggressive) and the stage, but can include observation, chemotherapy, radiation, or a combination of chemotherapy and radiation.
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Radiation plays an important role in the treatment of limited-stage indolent and aggressive lymphomas, and may be of benefit for certain patients with advanced-stage aggressive NHL.
Keywords
- Overall Survival
- Hematopoietic Stem Cell Transplant
- Radiat Oncol Biol Phys
- Mantle Cell Lymphoma
- National Comprehensive Cancer Network
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 2011 Springer-Verlag Berlin Heidelberg
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Jang, J., Ng, A. (2011). Non-Hodgkin’s Lymphoma. In: Lu, J., Brady, L. (eds) Decision Making in Radiation Oncology. Medical Radiology(), vol 0. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16333-3_8
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DOI: https://doi.org/10.1007/978-3-642-16333-3_8
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