Abstract
Can we track life’s molecular processes within a living cell? Observing all its organelles, biomolecules, and even individual chemical species in the cellular environment is rapidly becoming possible in real time and with ever-increasing spatial resolution. This will help us to better understand the numerous mechanisms which allow life to emerge and to continue within the organism so that it behaves like a coherent whole. Moreover, environmental assaults, pathological changes, or any manifestations of biological disorder inside cells require sometimes prompt and at other times slow repair processes for life to endure and continue. Over the past several centuries, pharmacology has developed medicinal means to enable and assist patients to recover from both specific and non-specific diseases and health problems. Most of these medicines are destined to eventually find their way inside the cellular environment, where needed, to exert their action. A rather new area of technology in the service of pharmacology is called ‘targeted drug delivery’, and it is dedicated to improvement in the delivery of certain drugs to their target organs. Pharmaceutical companies and research laboratories in academia have been investing in this sector heavily, due to its early promise. Encouraging advances in specific areas, especially in regard to the outer cellular regions, have been made, but no considerable progress has so far been seen regarding the issue of drug delivery into specific sections or targets in a cellular interior environment.
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References
Ashrafuzzaman, M., Lampson, M.A., Greathouse, D.V., Koeppe, R.E. II, Andersen, O.S.: Manipulating lipid bilayer material properties using biologically active amphipathic molecules. J. Phys.: Condens. Matter 18, S1235–55 (2006)
Ashrafuzzaman, M., Andersen, O.S., McElhaney, R.N.: The antimicrobial peptide gramicidin S permeabilizes phospholipid bilayer membranes without forming discrete ion channels. Biochim. Biophys. Acta. 1778, 2814–22 (2008)
Bruchez, M., Moronne, M., Gin, P., Weiss, S., Alivisatos, A.P.: Semiconductor nanocrystals as fluorescent biological labels. Science 281, 2013–2016 (1998)
Chan, W.C.W., Nie, S.M.: Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 281, 2016–2018 (1998)
de la Isla, A., Brostow, W., Bujard, B., Estevez, M., Rodriguez, J.R., Vargas, S., Castano, V.M.: Nanohybrid scratch resistant coating for teeth and bone viscoelasticity manifested in tribology. Mat Resr Innovat 7, 110–114 (2003)
Edelstein, R.L., Tamanaha, C.R., Sheehan, P.E., Miller, M.M., Baselt, D.R., Whitman, L.J., Colton, R.J.: The BARC biosensor applied to the detection of biological warfare agents. Biosensors Bioelectron 14, 805–813 (2000)
Hamoudeh, M., Salim, H., Barbos, D., Paunoiu, C., and Fessi, H.: Preparation and characterization of radioactive dirhenium decacarbonyl-loaded PLLA nanoparticles for radionucleide intra-tumoral therapy. Eur. J. of Pharm. And Biopharm. 67, 597–611 (2007)
Harper, P.E., Mannock, D.A., Lewis, R.N.A.H., McElhaney, R.N. and Gruner, S.M.: X-Ray Diffraction structures of Some Phosphatidylethanolamine Lamellar and Inverted Hexagonal Phases. Biophys. J. 81, 2693–2706 (2001)
Israelachvili, J.N., Mitchell, D.J. and Ninham, B. W.: Theory of self-assembly of hydrocarbon amphiphiles into micelles and bilayers. J. Chem. Soc., Faraday Trans. 2 72, 1525–1568 (1976)
Israelachvili, J.N., Mitchell, D.J. and Ninham, B. W.: Theory of self-assembly of lipid bilayers and vesicles. Biochim. Biophys. Acta 470, 185–201 (1977)
Leroueil, P. R., Hong, S., Mecke, A., Baker, J. R. Jr., Orr, B. G. and Holl, M. M. B.: nanoparticle interaction with biological membranes: does nanotechnology present a Janus Face? Acc. Chem. Res. 40, 335–342 (2007)
Ma, J., Wong, H., Kong, L.B., Peng, K.W.: Biomimetic processing of nanocrystallite bioactive apatite coating on titanium. nanotechnology 14,619–623 (2003)
Mah, C., Zolotukhin, I., Fraites, T.J., Dobson, J., Batich, C., Byrne, B.J.: Microsphere-mediated delivery of recombinant AAV vectors in vitro and in vivo. Mol Therapy 1, S239 (2000)
Mahtab, R., Rogers, J.P., Murphy, C.J.: protein-sized quantum dot luminescence can distinguish between “straight”, “bent”, and “kinked” oligonucleotides. J Am Chem Soc 117, 9099–9100 (1995)
Mecke, A., Uppuluri, S., Sassanella, T. J., Lee, D.-K., Ramamoorthy, A., Baker, J.R., Orr, B.G. and Holl, M.M.B.: Direct observation of lipid bilayer disruption by poly(amidoamine) dendrimers. Chem. Phys. Lipids 132, 3–14 (2004)
Mecke, A., Lee, D.-K., Ramamoorthy, A., Orr, B.G. and Holl, M.M.B.: Synthetic and natural polycationic polymer nanoparticles interact selectively with fluid-phase domains of DMPC bilayers. Langmuir 21, 8588–8590 (2005)
Mecke, A., Majoros, I. J., Patri, A. K., Baker, J.R. Jr., Holl, M.M.B. and Orr, B.G.: Lipid Bilayer Disruption by polycationic Polymers: The Roles of Size and chemical Functional Group. Langmuir 21, 10348–10354 (2005)
Molday, R.S., MacKenzie, D.: Immunospecific ferromagnetic iron dextran reagents for the labeling and magnetic separation of cells. J Immunol Methods 52,353–367 (1982)
Nam, J.M., Thaxton, C.C., Mirkin, C.A.: nanoparticles-based bio-bar codes for the ultrasensitive detection of proteins. Science 301, 1884–1886 (2003)
Panatarotto, D., Prtidos, C.D., Hoebeke, J., Brown, F., Kramer, E., Briand, J.P., Muller, S., Prato, M., Bianco, A.: Immunization with peptide-functionalized carbon nanotubes enhances virus-specific neutralizing antibody responses. Chemistry& Biology 10, 961–966 (2003)
Parak, W.J., Boudreau, R., Gros, M.L., Gerion, D., Zanchet, D., Micheel, C.M., Williams, S.C., Alivisatos, A.P., Larabell, C.A.: Cell motility and metastatic potential studies based on quantum dot imaging of phagokinetic tracks. Adv. Mater. 14, 882–885 (2002)
Roiter, Y., Ornatska, M., Rammohan, A.R., Balakrishnan, J., Heine, D.R. and Minko, S.: Interaction of Nanoparticles with Lipid Membrane. Nano Lett. 8(3), 941944 (2008)
Stein, W.D.: transport and diffusion across Cell Membranes. Academic Press: Orlando, FL, (1986)
Villars, F.M.H. and Benedek, G. B.: Physics with illustrative examples from Medicine and Biology, Vol 2.: Statistical Physics. Addison-Wesley Pub. Co., Inc. Reading, Massachusetts, California, USA (1974)
Wang, S., Mamedova, N., Kotov, N.A., Chen, W., Studer, J.: Antigen/antibody immunocomplex from CdTe nanoparticle bioconjugates. Nano Letters 2,817–822 (2002)
Weissleder, R., Elizondo, G., Wittenburg, J., Rabito, C.A., Bengele, H.H., Josephson, L.: Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging. Radiology 175:489–493 (1990)
Yoshida, J., Kobayashi, T.: Intracellular hyperthermia for cancer using magnetite cationic liposomes. J Magn Magn Mater 194, 176–184 (1999)
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Ashrafuzzaman, M., Tuszynski, J. (2012). Membrane-Based Nanotechnology and Drug Delivery. In: Membrane Biophysics. Biological and Medical Physics, Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16105-6_6
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DOI: https://doi.org/10.1007/978-3-642-16105-6_6
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