Abstract
Pulmonary complications in patients with hematological malignancies typically are associated with severe morbidity and frequently result in fatal outcome. The majority of these events are pneumonias caused by microbial pathogens, among which invasive fungal infections are the most life-threatening subgroup. Other microorganisms primarily resistant to broad-spectrum antibacterial agents, particularly viruses, Pneumocystis jiroveci, mycobacteria and multi-resistant bacteria, must be addressed by adequate diagnostic procedures, but important differential diagnoses apart from infectious diseases must be taken into consideration as well, first of all pulmonary side effects from cytotoxic drugs, radiotherapy or pulmonary involvement by the underlying malignancy. Clinical outcome may be favorable also in patients with severe respiratory failure, so that intensive care referral and invasive cardiorespiratory intervention are ethically justified in patients whose clinical course is not expected to be unequivocally fatal.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Ahmed S, Siddiqui AK, Rossoff L, Sison CP, Rai KR (2003) Pulmonary complications in chronic lymphocytic leukemia. Cancer 98:1912–1917
Azoulay E, Darmon M, Delclaux C et al (2002) Deterioration of previous acute lung injury during neutropenia recovery. Crit Care Med 30:781–786
Azoulay E, Thiery G, Chevret S et al (2004) The prognosis of acute respiratory failure in critically ill cancer patients. Medicine (Baltimore) 83:360–370
Bodey G, Bueltmann B, Duguid W et al (1992) Fungal infections in cancer patients: an international autopsy survey. Eur J Clin Microbiol Infect Dis 11:99–109
Caillot D, Casasnovas O, Bernard A et al (1997) Improved management of invasive pulmonary aspergillosis in neutropenic patients using early thoracic computed tomographic scan and surgery. J Clin Oncol 15:139–147
Camus P, Costabel U (2005) Drug-induced respiratory disease in patients with hematological diseases. Semin Respir Crit Care Med 26:458–81
Carratalà J, Rosón B, Fernández-Sevilla A, Alcaide F, Gudiol F (1998) Bacteremic pneumonia in neutropenic patients with cancer: causes, empirical antibiotic therapy, and outcome. Arch Intern Med 158:868–872
Cazzadori A, di Perri G, Todeschini G et al (1995) Transbronchial biopsy in the diagnosis of pulmonary infiltrates in immunocompromised patients. Chest 107:101–106
Chamilos G, Luna M, Lewis RE et al (2006) Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center: an autopsy study over a 15-year period (1989-2003). Haematologica 91:986–989
Chaoui D, Legrand O, Roche N et al (2004) Incidence and prognostic value of respiratory events in acute leukemia. Leukemia 18:670–675
Chemaly RF, Torres HA, Aguilera EA et al (2007) Neuraminidase inhibitors improve outcome of patients with leukemia and influenza: an observational study. Clin Infect Dis 44:964–967
Cornillet A, Camus C, Nimubona S et al (2006) Comparison of epidemiological, clinical, and biological features of invasive aspergillosis in neutropenic and nonneutropenic patients: a 6-year survey. Clin Infect Dis 43:577–584
Danés C, Gonzalez-Martin J, Pumarola T et al (2002) Pulmonary infiltrates in immunosuppressed patients: analysis of a diagnostic protocol. J Clin Microbiol 40: 2134–2140
Daniels CE, Myers JL, Utz JP, Markovic SN, Ryu JH (2007) Organizing pneumonia in patients with hematologic malignancies: a steroid-responsive lesion. Respir Med 101: 162–168
Ewig S, Glasmacher A, Ulrich B et al (1998) Pulmonary infiltrates in neutropenic patients with acute leukemia during chemotherapy. Chest 114:444–451
Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE (2005) Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med 352:1749–1759
Groll AH, Shah PM, Mentzel C, Schneider M, Just-Nuebling G, Huebner K (1996) Trends in the postmortem epidemiology of invasive fungal infections at a university hospital. J Infect 33:23–32
Jules-Elysee K, Stover DE, Yahalom J, White DA, Gulati SC (1992) Pulmonary complications in lymphoma patients treated with high-dose therapy autologous bone marrow transplantation. Am Rev Respir Dis 146:485–491
Kuderer NM, Dale DC, Crawford J, Cosler LE, Lyman GH (2006) Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients. Cancer 106: 2258–2266
Lass-Flörl C, Resch G, Nachbaur D (2007) The value of computed tomography-guided percutaneous lung biopsy for diagnosis of invasive fungal infection in immunocompromised patients. Clin Infect Dis 45:e101–e104
Lin MY, Weinstein RA, Hota B (2008) Delay of active antimicrobial therapy and mortality among patients with bacteremia: impact of severe neutropenia. Antimicrob Agents Chemother 52:3188–3194
Lin SJ, Schranz J, Teutsch SM (2001) Aspergillosis case-fatality rate: systematic review of the literature. Clin Infect Dis 32:358–366
Martino R, Ramila E, Rabella N et al (2003) Respiratory virus infections in adults with hematologic malignancies: a prospective study. Clin Infect Dis 36:1–8
Maschmeyer G, Beinert T, Buchheidt D et al (2009) Diagnosis and antimicrobial therapy of pulmonary infiltrates in febrile neutropenic patients. 2008 updated guidelines of the Infectious Diseases Working Party of the German Society of Hematology and Oncology. Eur J Cancer 45:2462–2472
Maschmeyer G, Bertschat FL, Häusler E et al (2003) Outcome analysis of 189 consecutive cancer patients referred to the intensive care unit as emergencies during a 2-year period. Eur J Cancer 39:783–792
Maschmeyer G, Link H, Hiddemann W et al (1994) Pulmonary infiltrations in febrile neutropenic patients. Risk factors and outcome under empirical antimicrobial therapy in a randomized multicenter trial. Cancer 73:2296–2304
Mossad SB, Longworth DL, Goormastic M, Serkey JM, Keys TF, Bolwell BJ (1996) Early infectious complications in autologous bone marrow transplantation: a review of 219 patients. Bone Marrow Transplant 18:265–271
Pagano L, Caira M, Candoni A et al (2006) The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study. Haematologica 91: 1068–1075
Raad II, Whimbey EE, Rolston KVI et al (1996) A comparison of aztreonam plus vancomycin and imipenem plus vancomycin as initial therapy for febrile neutropenic cancer patients. Cancer 77:1386–1394
Reich G, Mapara MY, Reichardt P, Dörken B, Maschmeyer G (2001) Infectious complications after high-dose chemotherapy and autologous stem cell transplantation: comparison between patients with lymphoma or multiple myeloma and patients with solid tumors. Bone Marrow Transplant 27:525–529
Rossini F, Verga M, Pioltelli P et al (2000) Incidence and outcome of pneumonia in patients with acute leukemia receiving first induction therapy with anthracycline-containing regimens. Haematologica 85:1255–1260
Safdar A, Rolston KV (2007) Stenotrophomonas maltophilia: changing spectrum of a serious bacterial pathogen in patients with cancer. Clin Infect Dis 45:1602–1609
Samonis G, Kontoyiannis DP (2001) Infectious complications of purine analog therapy. Curr Opin Infect Dis 14: 409–413
Schiel X, Link H, Maschmeyer G (2006) A prospective, randomized multicenter trial of the empirical addition of antifungal therapy for febrile neutropenic cancer patients. Infection 34:118–126
Shorr AF, Susla GM, O’Grady NP (2004) Pulmonary infiltrates in the non-HIV-infected immunocompromised patient: etiologies, diagnostic strategies, and outcomes. Chest 125:260–271
Suzuki HI, Asai T, Tamaki Z, Hangaishi A, Chiba S, Kurokawa M (2008) Drug-induced hypersensitivity syndrome with rapid hematopoietic reconstitution during treatment for acute myeloid leukemia. Haematologica 93: 469–470
Torres HA, Aguilera EA, Mattiuzzi GN et al (2007) Characteristics and outcome of Respiratory Syncytial Virus infection in patients with leukemia. Haematologica 92:1216–1223
Vehreschild JJ, Böhme A, Buchheidt D et al (2007) A double-blind trial on prophylactic voriconazole or placebo during induction chemotherapy for acute myelogenous leukaemia. J Infect 55:445–449
Walsh TJ, Anaissie EJ, Denning DW et al (2008) Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis 46:327–360
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Maschmeyer, G. (2011). Epidemiology of Respiratory Events in Patients with HM (Not Including ICU). In: Azoulay, E. (eds) Pulmonary Involvement in Patients with Hematological Malignancies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-15742-4_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-15742-4_4
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-15741-7
Online ISBN: 978-3-642-15742-4
eBook Packages: MedicineMedicine (R0)