Skip to main content
SpringerLink
Log in
Book cover

Computational Intelligence in Healthcare 4 pp 265–287Cite as

Explaining Medical Model Exceptions

  • Chapter

Part of the book series: Studies in Computational Intelligence ((SCI,volume 309))

Abstract

In this chapter, a system named ISOR is presented, that supports research doctors to investigate and to explain cases that do not fit a theoretical hypothesis. The system is designed for situations where neither a well-developed theory nor reliable knowledge nor, at the beginning, a case base is available. Instead of theoretical knowledge and intelligent experience, just a theoretical hypothesis and a set of measurements are given. ISOR is a Case-Based Reasoning system. That means, when attempting to find an explanation for an exceptional case, solutions of already explained similar exceptional cases are considered. However, ISOR uses further knowledge sources, especially a dialog where the user (a research doctor) can make suggestions for an explanation. ISOR is domain independent and can be applied to various research problems. However, in this chapter, it is focused on the hypothesis that a specific exercise program improves the physical condition of dialysis patients. Since many data are missing for this research problem, a method to impute missing data was developed and is also presented here. This method combines general domain independent techniques with domain knowledge provided by a medical expert. For the latter technique Case-based Reasoning is applied again.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Schank, R.C., Leake, D.B.: Creativity and learning in a case-based explainer. Artificial Intelligence 40, 353–385 (1989)

    Article  Google Scholar 

  2. Kolodner, J.: Case-Based Reasoning. Morgan Kaufmann Publishers, San Mateo (1989)

    Google Scholar 

  3. Aamodt, A., Plaza, E.: Case-Based Reasoning: foundation issues. Methodological variation and system approaches. AI Commun. 7(1), 39–59 (1994)

    Google Scholar 

  4. Stottler, R.H., Henke, A.L., King, J.A.: Rapid retrieval algorithms for case-based reasoning. In: Proc of 11th Int Joint Conference on Artificial Intelligence, pp. 233–237. Morgan Kaufmann, San Mateo (1989)

    Google Scholar 

  5. Lenz, M., Auriol, E., Manago, M.: Diagnosis and decision support. In: Lenz, M., et al. (eds.) Case-Based Reasoning Technology. LNCS (LNAI), vol. 1400, pp. 51–90. Springer, Heidelberg (1998)

    Chapter  Google Scholar 

  6. Broder, A.: Strategies for efficient incremental nearest neighbor search. Pattern Recognition 23, 171–178 (1990)

    Article  Google Scholar 

  7. Wilke, W., Smyth, B., Cunningham, P.: Using Configuration Techniques for Adaptation. In: Lenz, M., Bartsch-Spörl, B., Burkhard, H.-D., Wess, S. (eds.) Case-Based Reasoning Technology, From Foundations to Applications, pp. 139–168. Springer, Heidelberg (1998)

    Chapter  Google Scholar 

  8. Gierl, L.: Klassifikationsverfahren in Expertensystemen für die Medizin. Mellen Univ. Press, Lewiston (1992)

    Google Scholar 

  9. Gierl, L., Bull, M., Schmidt, R.: CBR in Medicine. In: Lenz, M., Bartsch-Spörl, B., Burkhard, H.-D., Wess, S. (eds.) Case-Based Reasoning Technology. LNCS (LNAI), vol. 1400, pp. 273–297. Springer, Heidelberg (1998)

    Chapter  Google Scholar 

  10. Schmidt, R., Montani, S., Bellazzi, R., Portinale, L., Gierl, L.: Case-Based Reasoning for Medical Knowledge-based Systems. International Journal of Medical Informatics 64(2-3), 355–367 (2001)

    Article  Google Scholar 

  11. Nilsson, M., Sollenborn, N.: Advancements and trends in medical case-based reasoning: An overview of systems and system developments. In: Proceedings Seventeenth International Florida Artificial Intelligence Research Society Conference, pp. 178–183. AAAI Press, Menlo Park (2004)

    Google Scholar 

  12. Schmidt, R., Vorobieva, O.: Case-Based Reasoning Investigation of Therapy Inefficacy. Knowledge-Based Systems 19(5), 333–340 (2006)

    Article  Google Scholar 

  13. Aha, D.W., McSherry, D., Yang, Q.: Advances in conversational Case-Based Reasoning. Knowledge Engineering Review 20, 247–254 (2005)

    Article  Google Scholar 

  14. Kendall, M.G., Stuart, A.: The advanced theory of statistics. Macmillan publishing, New York (1979)

    MATH  Google Scholar 

  15. Hai, G.A.: Logic of diagnostic and decision making in clinical medicine. Politheknica publishing, St. Petersburg (2002)

    Google Scholar 

  16. Perner, P. (ed.): Case-Based Reasoning on Images and Signals. Springer, Heidelberg (2007)

    Google Scholar 

  17. Bichindaritz, I., Kansu, E., Sullivan, K.M.: Case-based Reasoning in Care-Partner. In: Smyth, B., Cunningham, P. (eds.) EWCBR 1998. LNCS (LNAI), vol. 1488, pp. 334–345. Springer, Heidelberg (1998)

    Chapter  Google Scholar 

  18. Montai, S., Magni, P., Bellazzi, R., Larizza, C., Roudsari, C., Carsson, E.R.: Integration model-based decision support in multi-modal reasoning system for managing type 1 diabetic patients. Artificial Intelligence in Medicine 29(1-2), 131–151 (2003)

    Article  Google Scholar 

  19. Prentzas, J., Hatzilgeroudis, I.: Integrating Hybrid Rule-Based with Case-Based Reasoning. In: Craw, S., Preeece, A. (eds.) ECCBR 2002. LNCS (LNAI), vol. 2416, pp. 336–349. Springer, Heidelberg (2002)

    Chapter  Google Scholar 

  20. Shuguang, L., Qing, J., George, C.: Combining case-based and model-based reasoning: a formal specification. In: Proc APSEC 2000, p. 416 (2000)

    Google Scholar 

  21. Corchado, J.M., Corchado, E.S., Aiken, J., Fyfe, C., Fernandez, F., Gonzalez, M.: Maximum likelihood Hebbian learning based retrieval method for CBR systems. In: Ashley, K.D., Bridge, D.G. (eds.) ICCBR 2003. LNCS, vol. 2689, pp. 107–121. Springer, Heidelberg (2003)

    Chapter  Google Scholar 

  22. Rezvani, S., Prasad, G.: A hybrid system with multivariate data validation and Case-based Reasoning for an efficient and realistic product formulation. In: Ashley, K.D., Bridge, D.G. (eds.) ICCBR 2003. LNCS, vol. 2689, pp. 465–478. Springer, Heidelberg (2003)

    Chapter  Google Scholar 

  23. Arshadi, N., Jurisica, I.: Data Mining for Case-based Reasoning in high-dimensional biological domains. IEEE Transactions on Knowledge and Data Engineering 17(8), 1127–1137 (2005)

    Article  Google Scholar 

  24. Davidson, A.M., Cameron, J.S., Grünfeld, J.-P. (eds.): Oxford Textbook of Nephrology, vol. 3. Oxford University Press, Oxford (2005)

    Google Scholar 

  25. McSherry, D.: Interactive Case-Based Reasoning in sequential diagnosis. Applied Intelligence 14(1), 65–76 (2001)

    Article  MATH  Google Scholar 

  26. Little, R., Rubin, D.: Statistical analysis with missing data. John Wiley & Sons, Chichester (1987)

    MATH  Google Scholar 

  27. Fleiss, J.: The design and analysis of clinical experiments. John Wiley & Sons, Chichester (1986)

    MATH  Google Scholar 

  28. Gediga, G., Düntsch, I.: Maximum Consistency of Incomplete Data via Non-Invasive Imputation. Artificial Intelligence Review 19(1), 93–107 (2003)

    Article  Google Scholar 

  29. Lieber, J.: Application of the revision theory to adaptation in Case-Based Reasoning: The conservative adaptation. In: Weber, R.O., Richter, M.M. (eds.) ICCBR 2007. LNCS (LNAI), vol. 4626, pp. 239–253. Springer, Heidelberg (2007)

    Chapter  Google Scholar 

  30. Codd, E.F.: Providing OLAP (On-Line Analytic Processing) to User-Analysts: Am IT Mandate. E.F. Codd and Associates (1994)

    Google Scholar 

  31. Piatetsky-Shapiro, G., Frawley, W.J.: Knowledge Discovery in Databases. AAAI Press/The MIT Press (1991)

    Google Scholar 

  32. Cheng, J.G.: Outlier Management in Intelligent Data Analysis. PhD Thesis (2000), http://www.dcs.bbk.ac.uk/research/recentphds/gcheng.pdf (last visited May 2008)

  33. Papadimos, T.J., Marco, A.P.: The obligation of phyicians to medical outliers: a Kantian and Hegelian synthesis. BMC Medical Ethics 5(3) (2004)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute for Medical Informatics and Biometry, University of Rostock, Germany

    Rainer Schmidt & Olga Vorobieva

Authors
  1. Rainer Schmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Olga Vorobieva
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Technology/Computing and Software Systems, University ofWashington, Tacoma, 1900 Commerce Street, Campus Box 358426, 98402, Tacoma, WA, USA

    Isabelle Bichindaritz

  2. Flinders Medical Centre, Adelaide, South Australia, Australia

    Sachin Vaidya

  3. Royal Adelaide Hospital, Adelaide, South Australia, Australia

    Ashlesha Jain

  4. School of Electrical and Information Engineering, University of South Australia, SA 5095, South Australia, Australia

    Lakhmi C. Jain

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Schmidt, R., Vorobieva, O. (2010). Explaining Medical Model Exceptions. In: Bichindaritz, I., Vaidya, S., Jain, A., Jain, L.C. (eds) Computational Intelligence in Healthcare 4. Studies in Computational Intelligence, vol 309. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-14464-6_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-14464-6_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-14463-9

  • Online ISBN: 978-3-642-14464-6

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics

Search

Navigation