Skip to main content

T Cell Receptor Signalling Inspired Kernel Density Estimation and Anomaly Detection

  • Conference paper
Artificial Immune Systems (ICARIS 2009)

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 5666))

Included in the following conference series:

Abstract

The T cell is able to perform fine-grained anomaly detection via its T Cell Receptor and intracellular signalling networks. We abstract from models of T Cell signalling to develop a new Artificial Immune System concepts involving the internal components of the TCR. We show that the concepts of receptor signalling have a natural interpretation as Parzen Window Kernel Density Estimation applied to anomaly detection. We then demonstrate how the dynamic nature of the receptors allows anomaly detection when probability distributions vary in time.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Germain, R.N., Stefanov, I.: The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation. A. Rev. Imm., 17 (1999)

    Google Scholar 

  2. Altan-Bonnet, G., Germain, R.N.: Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLoS Biol. 3, 356 (2005)

    Article  Google Scholar 

  3. Owens, N.D.L., Timmis, J., Greensted, A., Tyrrell, A.: Modelling the Tunability of Early T cell Signalling Events. In: Bentley, P.J., Lee, D., Jung, S. (eds.) ICARIS 2008. LNCS, vol. 5132, pp. 12–23. Springer, Heidelberg (2008)

    Chapter  Google Scholar 

  4. Owens, N.D.L., Timmis, J., Greensted, A., Tyrrell, A.: Elucidation of T Cell Signalling Models. Submitted to Journal of Theoretical Biology (2009)

    Google Scholar 

  5. Feinerman, O., Veiga, J., Dorfman, J.R., Germain, R.N., Altan-Bonnet, G.: Variability and Robustness in T cell Activation from Regulated Heterogeneity in Protein Levels. Science 321 (2008)

    Google Scholar 

  6. Silverman, B.W.: Density Estimation for Statistics and Data Analysis. Chapman & Hall, Boca Raton (1986)

    Book  MATH  Google Scholar 

  7. Bishop, C.M.: Novelty Detection and neural network validation. IEE Proceedings of Vision, Image and Signal Processing 141, 4 (1994)

    Article  Google Scholar 

  8. Timmis, J., Andrews, P., Owens, N., Clark, E.: An Interdisciplinary Perspective on Artificial Immune Systems. Evolutionary Intelligence 1(1), 5–26 (2008)

    Article  MATH  Google Scholar 

  9. Stepney, S., Smith, R.E., Timmis, J., Tyrrell, A.M., Neal, M.J., Hone, A.N.W.: Conceptual Frameworks for Artificial Immune Systems. Int. J. Unconventional Computing 1(3), 315–338 (2005)

    Google Scholar 

  10. Stibor, T.: An Empirical Study of Self/Non-Self Discrimination in Binary Data with a Kernel Estimator. In: Bentley, P.J., Lee, D., Jung, S. (eds.) ICARIS 2008. LNCS, vol. 5132, pp. 352–363. Springer, Heidelberg (2008)

    Chapter  Google Scholar 

  11. Duda, O.R., Hart, P.E., Stork, D.G.: Pattern Classification. Wiley & Sons, Chichester (2001)

    MATH  Google Scholar 

  12. Bishop, C.M.: Neural Networks for Pattern Recognition. Oxford Univ. Press, Oxford (1995)

    MATH  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Owens, N.D.L., Greensted, A., Timmis, J., Tyrrell, A. (2009). T Cell Receptor Signalling Inspired Kernel Density Estimation and Anomaly Detection. In: Andrews, P.S., et al. Artificial Immune Systems. ICARIS 2009. Lecture Notes in Computer Science, vol 5666. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03246-2_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-03246-2_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-03245-5

  • Online ISBN: 978-3-642-03246-2

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics