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Spatial and Temporal Control of Cell Signaling by A-Kinase Anchoring Proteins

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Signal Transduction: Pathways, Mechanisms and Diseases

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Abstract

Scaffolding proteins help maintain order in the face of a chaotic cellular environment. Multifunctional binding proteins such as the A-kinase anchoring proteins (AKAPs) oversee the dynamic organization of signaling events by clustering kinases, phosphatases, phosphodiesterases and other signaling proteins. Many AKAPs facilitate the action of these enzymes toward their downstream targets, while several AKAPs act as downstream effectors themselves. This chapter focuses on the role of AKAPs in the spatial and temporal control of cAMP signaling events.

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Acknowledgments

We thank past and present members of the Scott Laboratory for helpful discussions. J.D.S. was supported in part by a grant from the National Institutes of Health (DK54441).

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Authors and Affiliations

  1. Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, HSC Room K-336, Seattle, WA, 98195, USA

    F. Donelson Smith, Lorene K. Langeberg & John D. Scott

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  1. F. Donelson Smith
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  2. Lorene K. Langeberg
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  3. John D. Scott
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Correspondence to John D. Scott .

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  1. Eye Research Institute, Oakland University, DHE 423, Rochester, 48309, USA

    Ari Sitaramayya

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Smith, F.D., Langeberg, L.K., Scott, J.D. (2010). Spatial and Temporal Control of Cell Signaling by A-Kinase Anchoring Proteins. In: Sitaramayya, A. (eds) Signal Transduction: Pathways, Mechanisms and Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02112-1_10

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