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Limbal Stem Cell Transplantation: Surgical Techniques and Results

  • Chapter
Book cover Cornea and External Eye Disease

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

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Core Messages

  • The ocular surface is composed of two functionally specialized epithelia that are both essential to maintain the surface integrity of the eye and the optical transparency of the cornea.

  • Ocular surface failure is thought to result from destruction of limbal epithelial stem cells (LESCs).

  • Penetrating keratoplasty (PKP) is seldom a successful treatment for surface failure because the limbal stem cells are not replaced, and thus the epithelial surface over the PKP will again ultimately fail.

  • Ocular surface reconstruction (OSR) is the restoration of the normal function of the ocular surface by surgical transplantation of limbal epithelial stem cells.

  • Available options for limbal stem cell transplantation include conjunctival limbal autograft transplantation (CLAU), living-related conjunctival limbal allograft transplantation (lr-CLAL), kera-tolimbal allograft transplantation (KLAL), and ex vivo expansion and transplantation of cultured limbal stem cells.

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Authors and Affiliations

  1. UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC, 1V 9EL, UK

    Alex J. Shortt

  2. Moorfields Eye Hospital, City Road, London, EC, 1V 2PD, UK

    Stephen J. Tuft

  3. Department of Ocular Biology and Therapeutics, UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC, 1V 9EL, UK

    Julie T. Daniels

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  1. Alex J. Shortt
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  2. Stephen J. Tuft
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  3. Julie T. Daniels
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Editors and Affiliations

  1. University Eye Hospital, Killianstraβe 5, Freiburg, 79106, Germany

    Thomas Reinhard (Professor and Chairman) (Professor and Chairman)

  2. Moorfields Eye Hospital, 162 City Road, London, EC1V 2PD, United Kingdom

    Frank Larkin

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Shortt, A.J., Tuft, S.J., Daniels, J.T. (2010). Limbal Stem Cell Transplantation: Surgical Techniques and Results. In: Reinhard, T., Larkin, F. (eds) Cornea and External Eye Disease. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85544-6_5

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