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#x203A; Hyperthermia is a peripherally (skin and muscle) mediated elevation of body temperature, which greatly differs from fever. Temperature is uncontrolled because the hypothalamic centre is not involved.
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› Hyperthermia, in contrast to fever, is uncommon, but it has to be considered in the differential diagnosis of elevated body temperature.
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› Although hyperthermia and fever cannot usually be differentiated clinically on the basis of the height of temperature, a temperature above 42°C suggests hyperthermia. A normal temperature excludes fever but not hyperthermia.
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› Hyperthermia has different causes, symptoms and signs than fever. Its management is specific and is also different from that of fever, e.g. antipyretics are ineffective while physical methods are effective.
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› Drugs play a major role in causing hyperthermia. In contrast to fever hyperthermia can largely be prevented.
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› Hyperthermia has many causes of which malignant hyperthermia (prototype of increased heat production) and heat stroke (prototype of decreased heat production) are the most common and serious causes.
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(2009). Hyperthermia. In: El-Radhi, A.S., Carroll, J., Klein, N. (eds) Clinical Manual of Fever in Children. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78598-9_2
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