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Bioactive Molecules and Medicinal Plants pp 85–100Cite as

Secondary Metabolite Production from Plant Cell Cultures: the Success Stories of Rosmarinic Acid and Taxol

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Abstract

Advances in scale-up approaches and immobilization techniques contribute to a considerable increase in the number of applications of plant cell cultures for the production of compounds with a high added value. The present review handles the cumulative progress in this field and focuses on the most recent developments regarding the in vitro production of plant-derived compounds with cancer chemotherapeutic or antioxidant properties, using rosmarinic acid (RA) and taxol as representative examples. Stimulation of biosynthetic pathways leads to enhanced RA accumulation in vitro. Critical issues are thoroughly discussed, including the dependence of in vitro, compound-specific production on culture growth and differentiation, elicitation strategies, physiological effects of immobilization, and the current status of scale-up production systems.

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Author information

Authors and Affiliations

  1. Laboratory of Plant Physiology, Faculty of Agricultural Biotechnology, Agricultural University of Athens, Iera Odos 75, 11855 , Athens, Greece

    Spiridon Kintzios

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  1. Spiridon Kintzios
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Editors and Affiliations

  1. Laboratory of Biomolecular Technology, Department of Botany, M.L. Sukhadia University, 313001, Udaipur, India

    K.G. Ramawat

  2. Groupe d‘Etude des Substances Végétales à Activité Biologique Laboratoire de Sciences Végétales, Mycologie et Biotechnologie,, UFR Pharmacie Universite Victor Segalen, 146 Rue Leo-Saignat, 33076, Bordeaux cedex, France

    J.M. Merillon

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Kintzios, S. (2008). Secondary Metabolite Production from Plant Cell Cultures: the Success Stories of Rosmarinic Acid and Taxol. In: Ramawat, K., Merillon, J. (eds) Bioactive Molecules and Medicinal Plants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74603-4_4

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