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Hormonal Control of Cell Cycle pp 111–121Cite as

Steroid Receptors, Stem Cells and Proliferation in the Human Breast

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Part of the book series: Research and Perspectives in Endocrine Interactions ((RPEI))

Abstract

This review summarises the current evidence for adult tissue stem cells in the human breast and examines the role of stemcells, steroids and self-renewal signalling pathways in normal human breast development. The development of the mammary gland is a complex and lengthy process, beginning during embryogenesis and not reaching full functionality until pregnancy and lactation. The gland goes through massive apoptosis and remodelling at the cessation of weaning to resemble once again the non-pregnant gland. The staged and cyclic development of the mammary gland is controlled by ovarian steroids, and it is thought to only be possible due to the presence of adult stem cells. Adult stem cells are self-renewing cells that give rise to all of the functional, differentiated cells of the tissue/organ. The process of self-renewal and stem cell maintenance is tightly controlled and thought to be regulated by signalling, such as through the Notch receptor pathway. Long-livedself-renewing stemcells are thought tobe the targetsof the accumulated mutations that lead to cancer. To fully determine the role of these cells and their signalling in cancer, it is important to first elucidate their function in normal breast development. A great deal of research has now been carried out into the identification and isolation of normal mammary stem cells.

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Author information

Authors and Affiliations

  1. Breast Biology Group, Division of Cancer Studies, Faculty of Medicine and Human Sciences, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, UK

    Hannah Harrison, Rebecca Lamb & Robert B. Clarke

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  1. Hannah Harrison
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  2. Rebecca Lamb
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  3. Robert B. Clarke
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Editor information

Editors and Affiliations

  1. Cedars-Sinai Medical Center, 8700 Beverly Blvd. Room 2015, CA 90048, Los Angeles, USA

    Shlomo Melmed

  2. CRLC Val d’Aurelle Bat B Cancer Research Center, 34298, Monpellier Cedex 5, France

    Henri Rochefort

  3. Service d’Endocrinologie, Hˆopital Bicˆetre, 78, avenue de G´eneral Leclerc, 94275, Kremlin-Bicˆetre, France

    Phillipe Chanson

  4. Pour la Recherche Thérapeutique, Fondation IPSEN, 24, rue Erlanger, 75781, Paris Cedex 16, France

    Yves Christen

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© 2008 Springer-Verlag Berlin Heidelberg

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Harrison, H., Lamb, R., Clarke, R. (2008). Steroid Receptors, Stem Cells and Proliferation in the Human Breast . In: Melmed, S., Rochefort, H., Chanson, P., Christen, Y. (eds) Hormonal Control of Cell Cycle. Research and Perspectives in Endocrine Interactions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-73855-8_11

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