Abstract
The type I interferons (IFN) are cytokines produced by mammalian cells in response to virus infection or other Stressors. IFNs exert antiviral function by binding to the IFNα/β receptors on the cell surface, with the major effect of triggering the JAK-STAT signaling cascade and inducing the expression of interferon-stimulated genes. The resulting innate antiviral response is a first line of immune defense against virus infection. Recent studies demonstrate that many viruses, including hepatitis C virus, direct processes to control the host response to infection. We provide a review of the virus/host processes involved in IFN signaling and regulation of innate immune defenses.
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© 2007 Springer-Verlag Berlin Heidelberg
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Loo, YM., Gale, M. (2007). Viral Regulation and Evasion of the Host Response. In: Pitha, P.M. (eds) Interferon: The 50th Anniversary. Current Topics in Microbiology and Immunology, vol 316. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71329-6_14
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DOI: https://doi.org/10.1007/978-3-540-71329-6_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-71328-9
Online ISBN: 978-3-540-71329-6
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