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Drug Effects on Learning and Memory

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Book cover Drug Discovery and Evaluation

With contributions by F.J. Hock, F.P. Huger, W.H. Vogel, J.D. Brioni, J.L. McGaugh and E. Dere

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Notes

  1. 1.

    Contribution by E. Dere.

References and Further Reading

  • Abdel-Hafez AA, Meselhy MR, Nakamura N, Hattori M, Watanabe H, Murakami Y, El-Gendy MA, Mahfouz NM, Mohamed TA (1998) Effects of paeoniflorin derivates on scopolamine-induced amnesia using a passive avoidance task in mice. Biol Pharm Bull 21:1174–1179

    Article  CAS  PubMed  Google Scholar 

  • Abe K, Takeyama C, Yoshimura K (1998) Effects of S-8510, a novel benzodiazepine receptor partial inverse agonist, on basal forebrain lesioning-induced dysfunction in rats. Eur J Pharmacol 347:145–152

    Article  CAS  PubMed  Google Scholar 

  • Ahmed MM, Hoshino H, Chikuma T, Yamada M, Kato T (2004) Effect of memantine on the levels of glia cells, neuropeptides, and peptide-degrading enzymes in rat brain regions of ibotenic acid-treated Alzheimer's disease model. Neuroscience 126:639–649

    Article  CAS  PubMed  Google Scholar 

  • Akhondzadeh S, Stone TW (1995) Induction of a novel form of hippocampal long-term depression by muscimol: Involvement of GABAA but not glutamate receptors. Br J Pharmacol 115:527–533

    Article  CAS  PubMed  Google Scholar 

  • Alger BE, Dhanjal SS, Dingledine R, Garthwaite J, Henderson G, King GL, Lipton P, North A, Schwartzkroin PA, Sears TA, Segal M, Whittingham TS, Williams J (1984) Brain slice methods. In: R. Dingledine (ed) Brain Slices, Plenum Press. New York, NY pp 381–437

    Google Scholar 

  • Alkondon M, Albuquerque EX (1993) Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes. J Pharmacol Exp Ther 265:1455–1473

    CAS  PubMed  Google Scholar 

  • Alvarez P, Zola-Morgan S, Squire LR (1994) The animal model of human amnesia: Long-term memory impaired and short-term memory intact. Proc Natl Acad Sci USA 91:5637–5641

    Article  CAS  PubMed  Google Scholar 

  • Alzheimer A (1907) Über eine eigenartige Erkrankung der Hirnrinde. Allg Z Psychiatr 64:146–148

    Google Scholar 

  • Anagnostopoulos AV, Mobraaten LE. Sharp JJ, Davisson MT (2001) Transgenic and knockout database: behavioral profiles of mouse mutants. Physiol Behav 73:675–689

    Article  CAS  PubMed  Google Scholar 

  • Anandatheerthavarada HK, Biswas G, Robin MA, Avadhani NG (2003) Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells. J Cell Biol 161:41–54

    Article  CAS  PubMed  Google Scholar 

  • Antal A, Kovanecz I, Bodis-Wollner I (1994) Visual discrimination and P300 are affected in parallel by cholinergic agents in the behaving monkey. Physiol Behav 56:161–166

    Article  CAS  PubMed  Google Scholar 

  • Aracava Y, Pereira EFR, Maelicke A, Albuquerque EX (2005) Memantine blocks α7* nicotinic acetylcholine receptors more potently than N-methyl-D-aspartate receptors in rat hippocampal neurones. J Pharmacol Exp Ther 312:1195–1205

    Article  CAS  PubMed  Google Scholar 

  • Araujo DM, Lapchak PA, Collier B, Quirion R (1988a) Characterization of N-[3H]methylcarbamylcholine on acetylcholine release in rat brain. J Neurochem 51:292–299

    Article  CAS  PubMed  Google Scholar 

  • Araujo DM, Lapchat PA, Robitaille Y, Gauthier S, Quirion R (1988b) Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease. J Neurochem 50:1914–1923

    Article  CAS  PubMed  Google Scholar 

  • Arendash GW, King DL, Gordon MC, Morgan D, Hatcher JM, Hope CE, Diamond DM (2001) Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes. Brain Res 891:42–53

    Article  CAS  PubMed  Google Scholar 

  • Arendt T, Henning D, Gray JA, Marchbanks R (1988) Loss of neurons in the rat forebrain cholinergic projection system after prolonged intake of ethanol. Brain Res Bull 21:563–5659

    Article  CAS  PubMed  Google Scholar 

  • Aronstam RS, Abood LG, Hoss W (1978) Influence of sulfhydryl reagents and heavy metals on the functional state of the muscarinic acetylcholine receptor in rat brain. Mol Pharmacol 14:575–586

    CAS  PubMed  Google Scholar 

  • Aronstam RS, Narayanan TK (1988) Temperature effect on the detection of muscarinic receptor-G protein interactions in ligand binding assays. Biochem Pharmacol 37:1045–1049

    Article  CAS  PubMed  Google Scholar 

  • Aspide R, Fresiello A, de Filippis G, Carnevale UA, Sadile AG (2000) Non-selective attention in a rat model of hyperactivity and attention deficit: subchronic methylphenidate and nitric oxide synthesis. Neurosci Biobehav Rev 24:59–71

    Article  CAS  PubMed  Google Scholar 

  • Atack JR, Perry EK, Bonham JR, Perry RH, Tomlinson BE, Blessed G, Fairbairn A (1983) Molecular forms of acetylcholinesterase in senile dementia of the Alzheimer type: Selective loss of the intermediate (10S) form. Neurosci Lett 40:199–204

    Article  CAS  PubMed  Google Scholar 

  • Augustinsson KB (1971) Determination of activity of cholinesterases. In: Glick D (ed) Methods of Biochemical Analysis, John Wiley & Sons, New York, pp 217–273

    Google Scholar 

  • Badio B, Daly JW (1994) Epibatidine, a potent analgesic and nicotinic agonist. Mol Pharmacol 45:563–569

    CAS  PubMed  Google Scholar 

  • Baldi E, Lorenzini CA, Sacchetti B, Tassoni G, Bucherelli C (1999) Effects of combined medial septal area, fimbria-fornix and entorhinal cortex tetrodotoxin inactivations on passive avoidance response consolidation in the rat. Brain Res 821:503–510

    Article  CAS  PubMed  Google Scholar 

  • Balfour DJK (1982) The effects of nicotine on brain neurotransmitter systems. Pharmacol Ther 16:269–282

    Article  CAS  PubMed  Google Scholar 

  • Banati RB, Rothe G, Valet G, Kreutzberg GW (1991) Respiratory burst in brain macrophages: a flow cytometric study on cultured brain macrophages. Neuropath Appl Neurobiol 17:223–230

    Article  CAS  Google Scholar 

  • Banati RB, Schubert P, Rothe G, Rudolphi K, Valet G, Kreutzberg GW (1994) Modulation of intracellular formation of reactive oxygen intermediates in peritoneal macrophages and microglial/brain macrophages by propentofylline. J Cerebr Blood Flow Metab 14:145–149

    Article  CAS  Google Scholar 

  • Banfi S, Cornelli U, Fonio W, Dorigotti L (1982) A screening method for substances potentially active on learning and memory. J Pharmacol Meth 8:255–263

    Article  CAS  Google Scholar 

  • Banks WA, Robinson SM, Verma S, Morley JE (2003) Efflux of human and mouse amyloid β proteins 1–40 and 1–42 from brain: impairment in a mouse model of Alzheimer's disease. Neuroscience 121:487–492

    Article  CAS  PubMed  Google Scholar 

  • Barclay LL, Gibson GE, Blass PJ (1981) The string test: An early behavioral change in thiamine deficiency. Pharmacol Biochem Behav 14:153–157

    Article  CAS  PubMed  Google Scholar 

  • Barnes CA (1979) Memory deficits associated with senescence: a neurophysiological and behavioral study in rat. J Comp Physiol Psychol 93:74–104

    Article  CAS  PubMed  Google Scholar 

  • Bartus RT (1979a) Physostigmine and recent memory: Effects in young and aged non-human primates. Science 206:1087–1089

    Article  CAS  PubMed  Google Scholar 

  • Bartus RT(1979b) Effects of aging on visual memory, sensory processing and discrimination learning in the non-human primate. In: Ordy JM, Brizzee K (eds) Aging. Vol. 10. Raven Press, New York, NY, pp 85–114

    Google Scholar 

  • Bartus RT, Dean RL (1981) Age-related memory loss and drug therapy: Possible directions based on animal models. In: Enna SJ, Samorajski T, Beer B (eds) Aging Vol. 17. Raven Press New York, NY, pp 209–223

    Google Scholar 

  • Bartus RT, Dean RL, Beer B (1980) Memory deficits in aged Cebus monkeys and facilitation with central cholinomimetics. Neurobiol Aging 1:145–152

    Article  CAS  Google Scholar 

  • Bartus RT, Dean RL, Beer B, Lippa AS (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408–417

    Article  CAS  PubMed  Google Scholar 

  • Bartus RT, Dean RL, Flicker C (1987) Cholinergic psychopharmacology: an integration of human and animal research on memory. In: Meltzer HY (ed) Psychopharmacology: The Third Generation of Progress. Raven Press, New York, pp 219–232

    Google Scholar 

  • Bartzokis G (2004) Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease. Neurobiol Aging 25:5–18

    Article  CAS  PubMed  Google Scholar 

  • Bashir ZI, Berreta N, Bortolotto ZA, Clark K, Davies CH, Frenguelli BG, Harvey J, Potier B, Collingridge GL (1994) NMDA receptors and long-term potentiation in the hippocampus. In: Collingridge GL, Watkins JC (eds) The NMDA Receptor. Second Ed. Oxford University Press, Oxford, New York, Tokyo, pp?294–312

    Google Scholar 

  • Battaglia F, Trinchese F, Liu S, Walter S, Nixob RA, Arancio O (2003) Calpain inhibitors, a treatment for Alzheimer's disease: position paper. J Mol Neurosci 20:357–362

    Article  CAS  PubMed  Google Scholar 

  • Baumeister R (2002) The worm in us – Caenorhabditis elegans as a model of human disease. Trends Biotechnol 20:147–148

    Article  CAS  PubMed  Google Scholar 

  • Bebbington A, Brimblecombe RW, Shakeshaft D (1966) The central and peripheral activity of acetylenic amines related to oxotremorine. Br J Pharmacol 26:56–57

    CAS  Google Scholar 

  • Beers DR, Henkel JS, Kesner RP, Stroop WG (1995) Spatial recognition memory deficits without notable CNS pathology in rats following herpes simplex encephalitis. J Neurol Sci 131:119–127

    Article  CAS  PubMed  Google Scholar 

  • Behnisch T, Reymann KG (1993) Co-activation of metabotropic glutamate and N-methyl-D-aspartate receptors is involved in mechanisms of long-term potentiation maintenance in rat hippocampal CA1 neurons. Neurosci 54:37–47

    Article  CAS  Google Scholar 

  • Bellavite P (1988) The superoxide-forming enzymatic system of phagocytes. Free Rad Biol Med 4:255–261

    Article  Google Scholar 

  • Bennett MC, Diamond DM, Stryker SL, Parks JK, Parker WD Jr (1992) Cytochrome oxidase inhibition: A novel animal model of Alzheimer's disease. J Geriatr Psychiatry Neurol 5:93–101

    CAS  PubMed  Google Scholar 

  • Bennett PC, Singaretnam LL, Zhao L-Q, Lawen A, Ng KT (1998) Peptidyl-prolyl-cis/trans-isomerase activity may be necessary for memory formation. FEBS Lett 431:386–390

    Article  CAS  PubMed  Google Scholar 

  • Bennett PC, Zhao W, Lawen A, Ng KT (1996) Cyclosporin A, an inhibitor of calcineurin, impairs memory formation in day-old chicks. Brain Res 730:107–117

    CAS  PubMed  Google Scholar 

  • Benveniste M, Mienville J-M, Sernagor E, Mayer ML (1990) Concentration-jump experiments with NMDA antagonists in mouse cultured hippocampal neurons. J Neurophysiol 63:1373–1384

    CAS  PubMed  Google Scholar 

  • Beresini MH, Sadick MD, Galloway AL, Yen R, Yeh SH, Chang AC, Shelton DL, Wong WLT (1997) Assays for small molecule agonists and agonists of the neurotrophin receptors. In: Devlin JP (ed) High Throughput Screening. The Discovery of Bioactive Substances. Marcel Dekker Inc., New York, Basel, pp?329–343

    Google Scholar 

  • Berridge MJ (1987) Inositol trisphosphate and diacylglycerol: two interacting second messengers. Ann Rev Biochem 56:159–193

    Article  CAS  PubMed  Google Scholar 

  • Berridge MJ, Irvine RF (1984) Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 312:315–321

    Article  CAS  PubMed  Google Scholar 

  • Beukers M, Boddeke EWGM (1991) Pharmacology of long-term potentiation. A model for learning reviewed. Pharm Weekbl Sci Ed 13:7–12

    Article  CAS  Google Scholar 

  • Birdsall NJM, Burgen ASV, Hulme EC (1978) The binding of agonists to brain muscarinic receptors. Mol Pharmacol 14:723–736

    CAS  PubMed  Google Scholar 

  • Birke LIA, Archer J (1983) Some issues and problems in the study of animal exploration. In: Archer J, Birke L (eds) Exploration in animals and humans, Van Nostrand Reinhold, Berkshire, UK

    Google Scholar 

  • Bjugstad KB, Flitter WD, Garland WA, Su GC, Arendash GW (1998) Preventive actions of a synthetic antioxidant in a novel animal model of AIDS dementia. Brain Res 795:349–357

    Article  CAS  PubMed  Google Scholar 

  • Blanpied TA, Clarke RJ, Johnson JW (2005) Amantadine inhibits NMDA receptors by accelerating channel closure during channel block. J Neurosci 25:3312–3322

    Article  CAS  PubMed  Google Scholar 

  • Bliss TVP, Lømo T (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol 232:331–356

    CAS  PubMed  Google Scholar 

  • Bon S, Vigny M, Massoulié J (1979) Asymmetric and globular forms of acetylcholinesterase in mammals and birds. Proc Natl Acad Sci USA 76:2546–2550

    Article  CAS  PubMed  Google Scholar 

  • Boncristiano S, Calhoun ME, Kelly PH, Pfeifer M, Bondolfi L, Stalder M, Phinney AL, Abramowski D, Sturchler-Pierat C, Enz A, Sommer B, Staufenbiel M, Jucker M (2002) Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis. J Neurosci 22:3234–3243

    CAS  PubMed  Google Scholar 

  • Bonnichsen RK, Brink NG (1955) Liver alcohol dehydrogenase. In: Colowick SP, Kaplan NO (eds) Methods of Enzymology, Vol. I, p. 241, Academic Press, New York

    Google Scholar 

  • Borlongan CV, Cahill DW, Sanberg PR (1995) Locomotor and passive avoidance deficits following occlusion of the middle cerebral artery. Physiol Behav 58:909–917

    Article  CAS  PubMed  Google Scholar 

  • Bourne RC, Davies DC, Stewart MG, Csillag A, Cooper M (1991) Cerebral glycoprotein synthesis and long-term memory formation in the chick (Gallus domesticus) following passive avoidance training depends on the nature of the aversive stimulus. Eur J Neurosci 3:243–248

    Article  PubMed  Google Scholar 

  • Braida D, Paladini E, Griffini P, Lamperti M, Colibretti L, Sala M (1998) Long-lasting antiamnesic effect of a novel anticholinesterase inhibitor (MF268). Pharmacol Biochem Behav 59:897–901

    Article  CAS  PubMed  Google Scholar 

  • Brakebusch C, Seidenbecher C, Asztely F, Rauch U, Matthies H, Meyer H, Krug M, Böckers TM, Zhou X, Kreutz MR, Montag D, Gundelfinger ED, Fässler R (2002) Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory. Mol Cell Biol 22:7417–7427

    Article  CAS  PubMed  Google Scholar 

  • Brandeis R, Dachir S, Sapir M, Levy A, Fisher A (1990) Reversal of age-related cognitive impairments by an M1 cholinergic agent, AF102B. Pharmacol Biochem Behav 36:89–95

    Article  CAS  PubMed  Google Scholar 

  • Brandeis R, Saphir M, Hafif N, Abraham S, Oz N, Stein E, Fisher A (1995) AF150(S): a new functionally selective M1 agonist improves cognitive performance in rats. Pharmacol Biochem Behav 51:667–674

    Article  CAS  PubMed  Google Scholar 

  • Brioni JD (1993) Role of GABA during the multiple consolidation of memory. Drug Dev Res 28:3–27

    Article  CAS  Google Scholar 

  • Brioni JD, Arolfo MP, Jerusalinski D, Medina JH, Izquierdo I (1991) The effect of flumazenil on acquisition, retention and retrieval of spatial information. Behav Neural Biol 56:329–335

    Article  CAS  PubMed  Google Scholar 

  • Brioni JD, Decker MW, Gamboa LP, Izquierdo I, McGaugh JL (1990) Muscimol injections in the medial septum impair spatial learning. Brain Res 522:227–234

    Article  CAS  PubMed  Google Scholar 

  • Brown JH, Brown SL (1984) Agonists differentiate muscarinic receptors that inhibit cyclic AMP formation from those that stimulate phosphoinositide metabolism. J Biol Chem 259:3777–3781

    CAS  PubMed  Google Scholar 

  • Brown PL, Jenkins HM (1968) Autoshaping of the pigeons key-peck. J Exp Anal Behav 11:1–8

    Article  CAS  PubMed  Google Scholar 

  • Brucato FH, Levin ED, Mott DD, Lewis DV, Wilson WA, Swartzwelder HS (1996) Hippocampal long-term potentiation and spatial learning in the rat: effects of GABAB receptor blockade. Neurosci 74:331–339

    Article  CAS  Google Scholar 

  • Brush FR (1971) Aversive Conditioning and Learning. Academic Press, New York and London

    Google Scholar 

  • Buck DL, Seager MA, Schreurs BG (2001) Conditioning-specific reflex modification of the rabbit (Oryctolagus cuniculus) nictitating membrane response: generality and nature of the phenomenon. Behav Neurosci 115:1039–1047

    Article  CAS  PubMed  Google Scholar 

  • Bures J, Buresova O (1963) Cortical spreading depression as a memory disturbing factor. J Comp Physiol Psychol 56:268–272

    Article  CAS  PubMed  Google Scholar 

  • Bures J, Fentom AA, Kaminsky Y, Zinyuk L (1997) Place cells and place navigation. Proc Natl Acad Sci USA 94:343–350

    Article  CAS  PubMed  Google Scholar 

  • Buresova O, Bures J, Oitzl M, Zahalka A (1985) Radial maze in the water tank: an aversively motivated spatial working memory task. Physiol Behav 34:1003–1005

    Article  CAS  PubMed  Google Scholar 

  • Buresova O, Krekule I, Zahalka A, Bures J (1985) On-demand platform improves accuracy of the Morris water maze. J Neurosci Meth 15:63–72

    Article  CAS  Google Scholar 

  • Burns RS, Chiueh CC, Markey SP, Ebert MH, Jacobowitz DM, Kopin IJ (1983) A primate model of Parkinsonism: Selective destruction of dopaminergic neurones in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine. Proc Natl Acad Sci USA 80:4546–4550

    Article  CAS  PubMed  Google Scholar 

  • Buwalda B, Nyakas C, Vosselman HJ, Luiten PGM (1995) Effects of postnatal anoxia on adult learning and emotion in rats. Behav Brain Res 67:83–90

    Article  Google Scholar 

  • Cadd GG, Hoyle GW, Quaife CJ, Marck B, Matsumoto AM, Brinster RL, Palmiter RD (1992) Alteration of neurotransmitter phenotype in noradrenergic neurons of transgenic mice. Mol Endocrinol 6:1951–1960

    Article  CAS  PubMed  Google Scholar 

  • Cai J-X, Arnstein AFT (1997) Dose-dependent effects of the dopamine receptor agonists A77636 and SKF81297 on spatial working memory in aged monkeys. J Pharmacol Exp Ther 283:183–189

    CAS  PubMed  Google Scholar 

  • Campbell BA, Church RM (1969) Punishment and Aversive Behavior. Appleton-Century-Crofts, New York

    Google Scholar 

  • Campbell BA, Spear NE (1972) Ontogeny of memory. Psychol Rev 79:215–236

    Article  CAS  PubMed  Google Scholar 

  • Capaldi EJ, Capaldi ED (1972) Aversive learning situations: apparatus and procedures. In: Myers RD (ed) Methods in Psychobiology, Vol. 2, Academic Press, London and New York, NY, pp 59–81

    Google Scholar 

  • Car H, Wiśniewski K (1998) The effect of baclofen and AP-7 on selected behavior in rats. Pharmacol Biochem Behav 59:685–689

    Article  CAS  PubMed  Google Scholar 

  • Carli M, Bonalumi P, Samanin R (1997) Way 100635, a 5-HT1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal administration of scopolamine or 7-chloro-kynurenic acid. Brain Res 774:167–174

    Article  CAS  PubMed  Google Scholar 

  • Caudle RM (1993) The demonstration of long latency potentials in the CA1 region of the rat hippocampal slice. Brain Res 613:247–250

    Article  CAS  PubMed  Google Scholar 

  • Caulfield MP (1993) Muscarinic receptors – characterization, coupling and function. Pharmacol Ther 58:319–379

    Article  CAS  PubMed  Google Scholar 

  • Cerbone A, Sadile AG (1994) Behavioral habituation to spatial novelty in rats: interference and non-interference studies. Neurosci Biobehav Rev 18:497–518

    Article  CAS  PubMed  Google Scholar 

  • Ceullo AC, Sofroniew MV (1984) The anatomy of the CNS cholinergic neurons. TINS 7:74–78

    Google Scholar 

  • Chambers RA, Moore J, McEnvoy JP, Levin ED (1996) Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia. Neuropsychopharmacology 15:587–594

    Article  CAS  PubMed  Google Scholar 

  • Chan SL, Shirachi DY, Bhargava HN, Gardner E, Trevor AJ (1972) Purification and properties of multiple forms of brain acetylcholinesterase. J Neurochem 19:2747–2758

    Article  CAS  PubMed  Google Scholar 

  • Chance B, Maehly AC (1955)Catalase assay by the disappearance of peroxide. In: Colowick SP, Kaplan NO (eds) Methods of Enzymology, Vol. II, pp?764–768, Academic Press, New York

    Google Scholar 

  • Chandler MJ, DeLeo JA, Carney JM (1985) An unanesthetized-gerbil model of cerebral ischemia-induced behavioral changes. J Pharmacol Meth 14:137–146

    Article  CAS  Google Scholar 

  • Changeux JP, Bertrand D, Corringer PJ, Dehaene S, Edelstein S, Léna C, LeNovère N, Marubio L, Picciotto M, Zoli M (1998) Brain nicotinic receptors: structure and regulation, role in learning and reinforcement. Brain Res Rev 26:198–216

    Article  CAS  PubMed  Google Scholar 

  • Chapman S, Fisher A, Weinstock M, Brandies R, Shohami E, Michaelson DM (1998) The effects of the acetylcholinesterase inhibitor ENA713 and the M1?agonist AF 150(S) on apolipoprotein E deficient mice. J Physiol (Paris) 92:34

    Article  Google Scholar 

  • Chemnitius J-M, Haselmeyer K-H, Zech R (1983) Brain cholinesterases: Differentiation of target enzymes for toxic organophosphorus compounds. Biochem Pharmacol 32:1693–1699

    Article  CAS  PubMed  Google Scholar 

  • Chen HSV, Lipton SA (2005) Pharmacological implications of two distinct mechanisms of interaction on memantine with N-methyl-D-aspartate-gated channels. J Pharmacol Exp Ther 31:961–971

    Article  CAS  Google Scholar 

  • Chen P, Ghoneim PP, Gormezano I (1992) Sodium pentobarbital: Sensory and associative effects in classical conditioning of the rabbit nictitating membrane response. Psychopharmacology 107:365–372

    Article  CAS  PubMed  Google Scholar 

  • Chen Z, Sugimoto Y, Kamei C (1997) Effects of histamine and its related compounds on impairment of passive avoidance response following hippocampal lesions in rats. J Brain Sci 23:225–240

    CAS  Google Scholar 

  • Cheng Y, Prusoff WH (1973) Relationship between the inhibition constant (K i) and the concentration of inhibitor which causes 50 percent inhibition (IC 50) of an enzymatic reaction. Biochem Pharmacol 22:3099–3108

    Article  CAS  PubMed  Google Scholar 

  • Chishti AM, Yang DS, Janus C, Phinney AL, Horne P, Pearson J, Strome R, Zuker N, Loukides J, French J, Turner S, Lozza G, Grilli M, Kunicki S, Morisette C, Paquette J, Gervais F, Bergeron C, Fraser PE, Carlson GA, St. George-Hyslop P, Westaway D (2001) Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant for of amyloid precursor protein 695. J Biol Chem 276:21562–21570

    Article  CAS  PubMed  Google Scholar 

  • Cho AK, Haslett WL, Jenden DJ (1962) The peripheral actions of oxotremorine, a metabolite of tremorine. J Pharmacol Exp Ther 138:249–257

    CAS  PubMed  Google Scholar 

  • Choi DW (1992) Excitotoxic cell death. J Neurobiol 23:1261–1276

    Article  CAS  PubMed  Google Scholar 

  • Choi DW, Koh JY, Peters S (1988) Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists. J Neurosci 8:185–195

    CAS  PubMed  Google Scholar 

  • Chorover SL, Schiller PH (1965) Short-term retrograde amnesia in rats. J Comp Physiol Psychol 59:73–78

    Article  CAS  PubMed  Google Scholar 

  • Christie JE, Shering A, Ferguson J, Glen AIM (1981) Physostigmine and arecoline: Effects of intravenous infusions in Alzheimer presenile dementia. Br J Psychiatry 138:46–50

    Article  CAS  PubMed  Google Scholar 

  • Cimadevilla JM, Fenton AA, Bures J (2001b) New spatial recognition tests for mice: passive place avoidance and active place avoidance on rotating arenas. Brain Res Bull 54:559–563

    Article  CAS  PubMed  Google Scholar 

  • Cimadevilla JM, Kaminsky Y, Fenton A, Bures J (2000) Passive and active place avoidance as a tool of spatial memory research in rats. J Neurosci Meth 102:155–164

    Article  CAS  Google Scholar 

  • Cimadevilla JM, Wesierska M, Fenton AA, Bures J (2001a) Inactivating one hippocampus impairs avoidance of a stable room-defined place during dissociation of arena cues from room cues by rotation of the arena. Proc Natl Acad Sci USA 98:3531–3536

    Article  CAS  PubMed  Google Scholar 

  • Clarke PBS (1987) Nicotine and smoking: A perspective from animal studies. Psychopharmacology 92:135–143

    CAS  PubMed  Google Scholar 

  • Clements MP, Bourne RC (1996) Passive avoidance learning in the day-old chick is modulated by GABAergic agents. Pharmacol Biochem Behav 53:629–634

    Article  CAS  PubMed  Google Scholar 

  • Cockcroft S, Gomperts BD (1985) Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase. Nature 313:534–536

    Article  Google Scholar 

  • Colombo PJ, Rivera DT, Martinez JL Jr, Bennett EL, Rosenzweig MR (1997) Evidence for localized and discrete roles for enkephalins during memory function in the chick. Behav Neurosci 111:114–122

    Article  CAS  PubMed  Google Scholar 

  • Conklin BR, Brann MR, Ma AL, Buckley NJ, Bonner TI, Axelrod J (1988) Stimulation of arachidonic acid release in transfected cells expressing cloned muscarinic receptors. Soc Neurosci Abst 14:600

    Google Scholar 

  • Connolly J, Boulter J, Heinemann SF (1992) α4-β2 and other nicotinic acetylcholine receptor subtypes as targets of psychoactive and addictive drugs. Br J Pharmacol 105:657–666

    Article  CAS  PubMed  Google Scholar 

  • Connor DJ, Langlais PJ, Thal LJ (1991) Behavioral impairment after lesions of the nucleus basalis by ibotenic acid and quisqualic acid. Brain Res 555:84

    Article  CAS  PubMed  Google Scholar 

  • Costentin J (1998) From gene to behavior, a new method for elaboration of new psychotropic agents. Ann Pharm Fr 56:60–67

    CAS  PubMed  Google Scholar 

  • Coyle JT (1983) Neurotoxic action of kainic acid. J Neurochem 41:1–11

    Article  CAS  PubMed  Google Scholar 

  • Coyle JT, Bird SJ, Evans RH, Gulley RL, Nadler JV, Nicklas WJ, Oley JW (1981) Excitatory amino acid neurotoxins: selectivity and mechanism of action. Neurosci Res Progr Bull 19:331–427

    Google Scholar 

  • Craik FJM (1977) Age differences in human memory. In: Birren JE, Schaie KW (eds) Handbook of the Psychobiology of Aging, Von Nostrand Reinhold Co., New York, NY, pp 384–420

    Google Scholar 

  • Croll SD, Greene NA, Lindsay RM, Wiegand SJ (1997) Sodium azide-induced learning deficits in rats: Time course and corresponding pathology. Psychobiology 25:34–47

    CAS  Google Scholar 

  • Crowe SF, Shaw S (1997) Salbutamol overcomes the effect of the noradrenergic neurotoxin DSP-4 on memory function in the day-old chick. Behav Pharmacol 8:216–222

    CAS  PubMed  Google Scholar 

  • Crowther DC, Kinghorn KJ, Page R, Lomas DA (2004) Therapeutic targets from a Drosophila model of Alzheimer's disease. Curr Opin Pharmacol 4:513–516

    Article  CAS  PubMed  Google Scholar 

  • D'Amato MR (1970) Experimental Psychology: Methodology, Psychophysics and Learning. McGraw-Hill, New York, pp 381–416

    Google Scholar 

  • Dai H, Krost M, Carey RJ (1995) A new methodological approach to the study of habituation: the use of positive and negative behavioral indices of habituation. J Neurosci Meth 62:169–174

    Article  CAS  Google Scholar 

  • Dajas-Bailador F, Wonnacott S (2004) Nicotine acetylcholine receptors and the regulation of neuronal signaling. Trends Pharmacol Sci 25:317–324

    Article  CAS  PubMed  Google Scholar 

  • Damsa G, Westerink GHC, Horn AS (1985) A simple, sensitive, and economic assay for choline and acetylcholine using HPLC, an enzyme reactor, and an electrochemical detector. J Neurochem 45:1649–1652

    Article  Google Scholar 

  • Davis KL, Mohs RC (1982) Enhancement of memory process in Alzheimer's disease with multiple dose intravenous physostigmine. Am J Psychiatry 139:1421–1424

    CAS  PubMed  Google Scholar 

  • Davis S, Bliss TVP, Dutrieux G, Laroche S, Errington ML (1997) Induction and duration of long-term potentiation in the hippocampus of the freely moving mouse. J Neurosci Methods 75:75–80

    Article  CAS  PubMed  Google Scholar 

  • De Boer T, Maura G, Raiteri M, de Vos CJ, Wieringa J, Pinder RM (1988) Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, ORG 3770 and its enantiomers. Neuropharmacology 27:399–408

    Article  PubMed  Google Scholar 

  • DeBelleroche JS, Gardiner IM (1982) Cholinergic action in the nucleus accumbens: Modulation of dopamine and acetylcholine release. Br J Pharmacol 75:359–365

    Article  CAS  Google Scholar 

  • Dean RL, Loullis C, Bartus RT (1983) Drug effects in an animal model of memory deficits in the aged: implications for future clinical trials. In: Walker RF, Cooper RL (eds) Experimental and Clinical Interventions in Aging. Marcel Dekker, New York, NY, pp 279–303

    Google Scholar 

  • Decker MW, Majchrzak MJ, Anderson DJ (1992) Effects of nicotine on spatial memory deficits in rats with spatial lesions. Brain Res 572:281–285

    Article  CAS  PubMed  Google Scholar 

  • Decker MW, Tran T, McGaugh JL (1990) A comparison of the effects of scopolamine and diazepam on acquisition and retention of inhibitory avoidance in mice. Psychopharmacology 100:515–521

    Article  CAS  PubMed  Google Scholar 

  • Dell'Anna ME, Calzolari S, Molinari M, Iuvone L, Calimici R (1991) Neonatal anoxia induces transitory hyperactivity, permanent spatial memory deficits and CA1 cell density reduction in developing rats. Behav Brain Res 45:125–134

    Article  PubMed  Google Scholar 

  • Deyo RA, Hittner JM (1995) Effects of the Ca2+?channel antagonist flunarizine on visual discrimination learning. Neurobiol Lear Memory 64:10–16

    Article  CAS  Google Scholar 

  • Dichter MA (1986) The pharmacology of cortical neurons in tissue culture. In: Electrophysiological Techniques in Pharmacology, Alan R. Liss, Inc., pp 121–147

    Google Scholar 

  • Dilts SL, Berry CA (1967) Effect of cholinergic drugs on passive avoidance in the mouse. J Pharmacol Exp Ther 158:279–285

    CAS  PubMed  Google Scholar 

  • Dingledine RY, Dodd Y, Kelly JS (1980) The in vitro brain slice as a useful neurophysiological preparation for intracellular recording. J Neurosci Methods 2:323–362

    Article  CAS  PubMed  Google Scholar 

  • Dovel I, Michaelson M (2004) A nontransgenic mouse model shows inducible amyloid-β (Aβ) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade. Proc Natl Acad Sci USA 101:13909–13914

    Article  Google Scholar 

  • Drachman DA, Leavitt J (1974) Human memory and the cholinergic system. Arch Neurol 30:113–121

    Article  CAS  PubMed  Google Scholar 

  • Drake J, Link CD, Butterfield DA (2003) Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid β-peptide (1–42) in a transgenic Caenorhabditis elegans model. Neurobiol Aging 24:415–420

    Article  CAS  PubMed  Google Scholar 

  • Drasdo A, Caulfield M, Bertrand D, Bertrand S, Wonnacott (1992) Methyllycaconitine: a novel nicotinic antagonist. Mol Cell Neurosci 3:237–243

    Article  CAS  PubMed  Google Scholar 

  • Drukarch B, Schepens E, Schoffelmeer ANM, Stoof JC (1989) Stimulation of D-2 dopamine receptors decreases the evoked in vitro release of [3H]-acetylcholine from rat neostriatum: Role of K+ and Ca2+. J Neurochem 52:1680–1685

    Article  CAS  PubMed  Google Scholar 

  • Du W, Harvey JA (1996) The nitric oxide synthesis inhibitor L-name facilitates associative learning. Prog Neuro-Psychopharmacol Biol Psychiatry 20:1183–1195

    Article  CAS  Google Scholar 

  • Du W, Harvey JA (1997) Harmaline-induced tremor and impairment of learning are both blocked by dizocilpine in the rabbit. Brain Res 745:183–188

    Article  CAS  PubMed  Google Scholar 

  • Dunn RW, Flanagan DM, Martin LL, Kerman LL, Woods AT, Camacho F, Wilmot CA, Cornfeldt ML, Effland RC, Wood PL, Corbett R (1992) Stereoselective R-(+) enantiomer of HA-966 displays anxiolytic effects in rodents. Eur J Pharmacol 214:207–214

    Article  CAS  PubMed  Google Scholar 

  • Dunnett SB, Whishaw IQ, Jones GH, Bunch ST (1989) Behavioral, biochemical and histochemical effects of different neurotoxic amino acids injected into nucleus basalis magnocellularis of rats. Neuroscience 20:653–669

    Article  Google Scholar 

  • Ehlert FJ (1985) The relationship between muscarinic receptor occupancy and adenylate cyclase inhibitor in the rabbit myocardium. Mol Pharmacol 28:410–421

    CAS  PubMed  Google Scholar 

  • Eichenbaum H, Otto T, Cohen NJ (1992) The hippocampus – what does it do? Behav Neural Biol 57:2–36

    Google Scholar 

  • El-Fakahani EE, Ramkumar V, Lai WS (1986) Multiple binding affinities of N-methylscopolamine to brain muscarinic acetylcholine receptors: differentiation from M1 and M2 subtypes. J Pharmacol Exp Ther 238:554–563

    Google Scholar 

  • El-Zahaby HM, Ghoneim MM, Johnson GM, Gormezano I (1994) Effects of subanesthetic concentrations of isoflurane and their interactions with epinephrine on acquisition and retention of the rabbit nictitating membrane response. Anesthesiology 81:229–237

    Article  CAS  PubMed  Google Scholar 

  • Ellison G (1995) The N-methyl-D-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of dementia. Brain Res Rev 20:250–267

    Article  CAS  PubMed  Google Scholar 

  • Ellman GL, Courtney KD, Andres V, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88–95

    Article  CAS  PubMed  Google Scholar 

  • Emre E, Qizilbash N (2001) Experimental approaches and drugs in development for the treatment of dementia. Exp Opin Invest Drugs 10:607–617

    Article  CAS  Google Scholar 

  • English JA, Hemphill KM, Paul IA (1998) LP-BM5 infection impairs acquisition, but not performance, of active avoidance responding in C57B1/6 mice. FASEB J 12:175–179

    CAS  PubMed  Google Scholar 

  • Ennaceur A (1998) Effects of lesions of the Substantia Innominata/Ventral Pallidum, Globus Pallidus and Medial Septum on rat's performance in object-recognition and radial-maze tasks: Physostigmine and amphetamine. Pharmacol Res 38:251–263

    Article  CAS  PubMed  Google Scholar 

  • Enz A, Boddeke H, Sauter A, Rudin M, Shapiro G (1993) SDZ ENS 163 a novel pilocarpin like drug: pharmacological in vitro and in vivo profile. Life Sci 52:513–520

    Article  CAS  PubMed  Google Scholar 

  • Errington ML, Lynch MA, Bliss TVP (1987) Long-term potentiation in the dentate gyrus: induction and increased glutamate release are blocked by D(–)aminophosphonovalerate. Neurosci 20:279–284

    Article  CAS  Google Scholar 

  • Fadda F, Rossetti ZL (1998) Chronic ethanol consumption: from neuroadaptation to neurodegeneration. Prog Neurobiol 15:385–431

    Article  Google Scholar 

  • Farr SA, Banks WA, Uezu K, Gaskin FS, Morley JE (2004) DHEAS improves learning and memory in aged SAMP8 mice but not in diabetic mice. Life Sci 75:2775–2785

    Article  CAS  PubMed  Google Scholar 

  • Fekete M, deWied D (1982) Potency and duration of action of the ACTH4–9 analog (ORG 2766) as compared to ACTH4–10 and [d-Phe7]ACTH4–10 on active and passive avoidance behavior of rats. Pharmacol Biochem Behav 16:387–392

    Article  CAS  PubMed  Google Scholar 

  • Fenton AA, Wesierska M, Kaminsky Y, Bures J (1998) Both here and there: simultaneous expression of autonomous spatial memories in rats. Proc Natl Acad Sci USA 95:11493–11498

    Article  CAS  PubMed  Google Scholar 

  • Ferber D (2001) Neurodegenerative disease: using the fruit fly to model tau malfunction. Science 292:1983–1984

    Article  CAS  PubMed  Google Scholar 

  • Fernandez-Ruiz J, Doudet DJ, Aigner TG (1995) Long-term cognitive impairment in MPTP-treated rhesus monkeys. Neuro-Report 7:102–104

    CAS  Google Scholar 

  • File SE (1980) The use of social interaction as a method for detecting anxiolytic activity in chlordiazepoxide-like drugs. J Neurosci Meth 2:219–238

    Article  CAS  Google Scholar 

  • Fine A, Dunnett SB, Björklund A, Iversen SD (1985) Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease. Proc Natl Acad Sci USA 82:5227–5230

    Article  CAS  PubMed  Google Scholar 

  • Finelli A, Kelkar A, Song HJ, Yang H, Konsolaki M (2004) A model for studying Alzheimer's Aβ42-induced toxicity in Drosophila melanogaster. Mol Cell Neurosci 26:365–375

    Article  CAS  PubMed  Google Scholar 

  • Fisher A, Brandeis R, Karton I, Pittel Z, Gurwitz D, Haring R, Sapir M, Levy A, Heldman E (1991) (±)-cis-2-Methylspiro(1,3-oxathiolane-5,3′)quinuclidine, an M1?selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease. J Pharmacol Exp Ther 257:392–403

    CAS  PubMed  Google Scholar 

  • Fisher A, Hanin I (1986) Potential animal models for senile dementia of Alzheimer's type, with emphasis on AF64A-induced cholinotoxicity. Ann Rev Pharmacol Toxicol 26:161–181

    Article  CAS  Google Scholar 

  • Fisher SK, Agranoff BW (1987) Receptor activation and inositol lipid hydrolysis in neural tissues. J Neurochem 48:999–1017

    Article  CAS  PubMed  Google Scholar 

  • Fisher SK, Bartus RT (1985) Regional differences in the coupling of muscarinic receptors to inositol phospholipid hydrolysis in guinea pig brain. J Neurochem 45:1085–1095

    Article  CAS  PubMed  Google Scholar 

  • Fisher SK, Domask LM, Roland RM (1989) Muscarinic receptor regulation of cytoplasmic Ca2+ concentrations in human SK-N-SH neuroblastoma cells: Ca2+ requirements for phospholipase C activation. Mol Pharmacol 35:195–204

    CAS  PubMed  Google Scholar 

  • Fisher SK, Figueiredo JC, Bartus RT (1984) Differential stimulation of inositol phospholipid turnover in brain by analogs of oxotremorine. J Neurochem 43:1171–1179

    Article  CAS  PubMed  Google Scholar 

  • Fisher SK, Klinger PD, Agranoff BW (1983) Muscarinic agonist binding and phospholipid turnover in brain. J Biol Chem 258:7358–7363

    CAS  PubMed  Google Scholar 

  • Flood JF, Morley JE (1998) Learning and memory in the SAMP8 mouse. Neurosci Biobehav Rev 22:1–20

    Article  CAS  PubMed  Google Scholar 

  • Fonnum F (1975) A rapid radiochemical method for the determination of choline acetyltransferase. J Neurochem 24:407–409

    Article  CAS  PubMed  Google Scholar 

  • Fox GB, Faden AI (1998) Traumatic brain injury causes delayed motor and cognitive impairment in a mutant mouse strain known to exhibit delayed Wallerian degeneration. J Neurosci Res 53:718–727

    Article  CAS  PubMed  Google Scholar 

  • Francis PT, Nordber A, Arnold SE (2005) A preclinical view of cholinesterase inhibitors in neuroprotection: do they provide more than symptomatic benefits in Alzheimer's disease? Trends Pharmacol Sci 26:104–111

    CAS  Google Scholar 

  • Frankiewicz T, Parsons CG (1999) Memantine restores long term potentiation impaired by tonic N-methyl-D- aspartate (NMDA) receptor activation following reduction of Mg2+ in hippocampal slices. Neuropharmacology 38:1253–1259

    Article  CAS  PubMed  Google Scholar 

  • Franowicz JS, Kessler LE, Borja CM, Kobilka BK, Limbird LE, Arnsten AF (2002) Mutation of the α2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine. J Neurosci 22:8771–8777

    CAS  PubMed  Google Scholar 

  • Frei K, Siepl C, Groscurth P, Bodmer S, Schwerdel C, Fontana A (1987) Antigen presentation and tumor cytotoxicity by interferon-γ-treated microglial cells. Eur J Immunol 17:1271–1278

    Article  CAS  PubMed  Google Scholar 

  • Frisch C, Dere E, de Souza Silva MA, Gödecke A, Schrader J, Huston JP (2000) Superior water maze performance and increase in fear-related behavior in the endothelial nitric oxide synthase-deficient mouse together with monoamine changes in cerebellum and ventral striatum. J Neurosci 20:6694–6700

    CAS  PubMed  Google Scholar 

  • Fuji K, Hiramatsu M, Hayashi S, Kameyama T, Nabeshima T (1993b) Effects of propentofylline, a NGF stimulator, on alterations in muscarinic cholinergic receptors induced by basal forebrain lesion in rats. Neurosci Lett 150:99–102

    Article  CAS  PubMed  Google Scholar 

  • Fuji K, Hiramatsu M, Kameyama T, Nabeshima T (1993a) Effects of repeated administration of propentofylline on memory impairment produced by basal forebrain lesion in rats. Eur J Pharmacol 236:411–417

    Article  CAS  PubMed  Google Scholar 

  • Fujibayashi Y, Waki A, Wada K, Ueno M, Magata Y, Yonekura Y, Konishi J, Takedaa T, Yokoyama A (1994) Differential aging pattern of cerebral accumulation of radiolabeled glucose and amino acid in the senescence accelerated mouse (SAM), a new model for the study of memory impairment. Biol Pharm Bull 17:102–105

    Article  CAS  PubMed  Google Scholar 

  • Fujii S, Sekino Y, Kuroda Y, Sasaki H, Ito KI, Kato H (1997) 8-Cyclopentyltheophylline, an adenosine A1 receptor antagonist, inhibits the reversal of long-term potentiation in hippocampal CA1 neurons. Eur J Pharmacol 33:9–14

    Article  Google Scholar 

  • Furukawa S, Furukawa Y, Akazawa S, Satoyoshi E, Itoh K, Hayashi K (1983) A highly sensitive enzyme immunoassay for mouse β nerve growth factor. J Neurochem 40:734–744

    Article  CAS  PubMed  Google Scholar 

  • Furukawa S, Furukawa Y, Satoyoshi E, Hayashi K (1986) Synthesis and secretion of nerve growth factor by mouse astroglial cells in culture. Biochem Biophys Res Commun 136:57–63

    Article  CAS  PubMed  Google Scholar 

  • Furukawa S, Furukawa Y, Satoyoshi E, Hayashi K (1987) Regulation of nerve growth factor synthesis/secretion by catecholamine in cultured mouse astroglial cells. Biochem Biophys Res Commun 147:1048–1054

    Article  CAS  PubMed  Google Scholar 

  • Gaffan D (1994) Scene-specific memory for objects: A model of episodic memory impairment in monkeys with fornix transection. J Cogn Neurosci 6:305–320

    Article  Google Scholar 

  • Gahtan E, Auerbach JM, Groner Y, Segal M (1998) Reversible impairment of long-term potentiation in transgenic Cu/Zn-SOD mice. Eur J Neurosci 10:538–544

    Article  CAS  PubMed  Google Scholar 

  • Galeotti N, Ghelardini C, Teodori E, Gualtieri F, Bartolini A (1997) Antiamnesic activity of metoclopramide, cisapride and SR-17 in the mouse passive avoidance test. Pharmacol Res 36:59–67

    Article  CAS  PubMed  Google Scholar 

  • Gallagher M, Burwell R, Burchinal M (1993) Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze. Behav Neurosci 107:618–626

    Article  CAS  PubMed  Google Scholar 

  • Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373:523–527

    Article  CAS  PubMed  Google Scholar 

  • Gandy S, Walker L (2004) Toward modeling hemorrhagic and encephalitic complications of Alzheimer amyloid-β vaccination in nonhuman primates. Curr Opin Immunol 16:607–615

    Article  CAS  PubMed  Google Scholar 

  • Gerlai R (1999) Ethological approaches in behavioral neurogenetic research. In: Crusio WE, Gerlai RT (eds) Handbook of Molecular-Genetic Techniques for Brain and Behavior Research (Techniques in the Behavioral and Neural Sciences, Vol. 13). Elsevier Science B.V. New York, pp 605–613

    Google Scholar 

  • Gervais-Fagnou DD, Tuchek JM (1996) Learning impairment in 1–2?day-old chicks. Epilepsia 37:322–327

    Article  CAS  PubMed  Google Scholar 

  • Ghoneim MM, Chen P, El-Zahaby HM, Block RI (1994) Ketamine: Acquisition and retention of classically conditioned responses during treatment with large doses. Pharmacol Biochem Behav 49:1961–1066

    Article  Google Scholar 

  • Ghoneim MM, El-Zahaby HM, Block RI (1999) Classical conditioning during nitrous oxide treatment: influence of varying the interstimulus interval. Pharmacol Biochem Behav 63:449–455

    Article  Google Scholar 

  • Gibbs ME, Barnett JM (1976) Drug effects on successive discrimination learning in young chickens. Brain Res Bull 1:295–299

    Article  CAS  PubMed  Google Scholar 

  • Gibbs ME, Ng KT (1976) Psychobiology of memory: Towards a model of memory formation. Biobehav Res 1:113–136

    Article  Google Scholar 

  • Gibbs ME, Ng KT (1979) Neuronal depolarization and the inhibition of short-term memory formation. Physiol Behav 23:369–375

    Article  CAS  PubMed  Google Scholar 

  • Gibson GE, Blass JP (1976) Impaired synthesis of acetylcholine in brain accompanying mild hypoxia and hypoglycemia. J Neurochem 27:37–42

    Article  CAS  PubMed  Google Scholar 

  • Gibson GE, Pelmas CJ, Peterson C (1983) Cholinergic drugs and 4-aminopyridine alter hypoxic-induced behavioral deficits. Pharmacol Biochem Behav 18:909–916

    Article  CAS  PubMed  Google Scholar 

  • Gibson GE, Peterson C (1981) Aging decreases oxidative metabolism and the release and synthesis of acetylcholine. J Neurochem 37:978–984

    Article  CAS  PubMed  Google Scholar 

  • Gibson GE, Pulsinelli W, Blass JP, Duffy TE (1981) Brain dysfunction in mild to moderate hypoxia. Am J Med 70:1247–1254

    Article  CAS  PubMed  Google Scholar 

  • Gibson GE, Shimada M, Blass JP (1978) Alterations in acetylcholine synthesis and cyclic nucleotides in mild cerebral hypoxia. J Neurochem 31:757–760

    Article  CAS  PubMed  Google Scholar 

  • Gilbert DB, Patterson TA, Rose SPR (1989) Midazolam induces amnesia in a simple, one-trial, maze-learning task in young chicks. Pharmacol Biochem Behav 34:439–442

    Article  CAS  PubMed  Google Scholar 

  • Gilbert RM (1969) Discrimination learning? In: Gilbert RM, Sutherland NS (eds) Animal Discrimination Learning. Academic Press, New York, NY and London, pp 455–498

    Google Scholar 

  • Gilman AG (1986) Receptor-regulated G proteins. TINS 9:460

    CAS  Google Scholar 

  • Giovannini MG, Bartolini L, Bacciottini L, Greco L, Blandina P (1999) Effects of histamine H3 receptor agonists and antagonists on cognitive performance and scopolamine-induced amnesia. Behav Brain Res 104:147–155

    Article  CAS  PubMed  Google Scholar 

  • Giulian D, Baker TJ (1986) Characterization of ameboid microglia isolated from developing mammalian brain. J Neurosci 6:2163–2178

    CAS  PubMed  Google Scholar 

  • Glick SD, Zimmerberg B (1972) Amnesic effects of scopolamine. Behav Biol 7:245–254

    Article  CAS  PubMed  Google Scholar 

  • Goedert M, Hasegawa M (1999) The Tauopathies. Toward an experimental animal model. Am J Pathol 154:1–6

    Article  CAS  PubMed  Google Scholar 

  • Gong B, Vitolo OV, Trinchese F, Liu S, Shelanski M, Arancio O (2004) Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. J Clin Invest 114:1624–1634

    CAS  PubMed  Google Scholar 

  • Gormezano I, Prokasy WF, Thompson RF (eds) (1987) Classical Conditioning: III. Behavioral, Physiological and Neurochemical Studies in the Rabbit. Hillsday NJ: Erlbaum

    Google Scholar 

  • Gotti C, Fornasaru D, Clementi F (1997) Human neuronal nicotinic receptors. Progr Neurobiol 53:199–237

    Article  CAS  Google Scholar 

  • Gouret C (1973) Etude de cinq tests rapides de sélection d'une activité anticholinergique chez la souris. J Pharmacol (Paris) 4:105–128

    CAS  Google Scholar 

  • Gouret C, Raynaud G (1976) Utilisation du test de la boite a deux compartiments pour la recherche de substances protégeant le rat contre l'amnésie par hypoxie: Intérèt at limites de la méthode. J Pharmacol (Paris) 7:161–175

    CAS  Google Scholar 

  • Gozes I, Glowa J, Brenneman DE, McCune SK, Lee E, Westphal H (1993) Learning and sexual deficiencies in transgenic mice carrying a chimeric vasoactive intestinal peptide gene. J Mol Neurosci 4:185–193

    Article  CAS  PubMed  Google Scholar 

  • Graeber MB, Kreutzberg GW (1986) Astrocytes increase in glial fibrillary acidic protein during retrograde changes of facial motor neurons. J Neurocytol 15:363–373

    Article  CAS  PubMed  Google Scholar 

  • Grassi J, Vigny M, Massoulié J (1982) Molecular forms of acetylcholinesterase in bovine caudate nucleus and superior cervical ganglion: solubility properties and hydrophobic character. J Neurochem 38:457–469

    Article  CAS  PubMed  Google Scholar 

  • Groves PM, Thompson RI (1970) Habituation: a dual-process theory. Psychol Rev 77:419–450

    Article  CAS  PubMed  Google Scholar 

  • Grüsser OJ, Klinke R (eds) Pattern Recognition in Biological and Technical Systems. Springer-Verlag, Berlin (1971)

    Google Scholar 

  • Gusovsky F, Daly JW (1988) Formation of inositol phosphates in synaptoneurosomes of guinea pig brain: stimulatory effects of receptor agonists, sodium channel agents and sodium and calcium ionophores. Neuropharmacol 27:95–105

    Article  CAS  Google Scholar 

  • Gusovsky F, Hollingsworth EB, Daly JW (1986) Regulation of phosphatidylinositol turnover in brain synaptoneurosomes: Stimulatory effects of agents that enhance influx of sodium ions. Proc Natl Acad Sci USA 83:3003–3007

    Article  CAS  PubMed  Google Scholar 

  • Gusovsky F, McNeal EZ, Daly JW (1987) Stimulation of phosphoinositide breakdown in brain synaptoneurosomes by agents that activate sodium influx: antagonism by tetrodotoxin, saxitoxin, and cadmium. Mol Pharmacol 32:479–487

    CAS  PubMed  Google Scholar 

  • Gutnikov SA, Gaffan D (1996) Systemic NMDA receptor antagonist CGP-40116 does not impair memory acquisition but protects against NMDA neurotoxicity in rhesus monkeys. J Neurosci 16:4041–4050

    CAS  PubMed  Google Scholar 

  • Götz J (2001) Tau and transgenic animal models. Brain Res Rev 35:266–286

    Article  PubMed  Google Scholar 

  • Götz J, Streffer JR, David D, Schild A, Hoerndli F, Pennanen L, Kurosinski P, Chen F (2004) Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy. Mol Psychiatry 9:664–683

    PubMed  Google Scholar 

  • Hadhazy P, Szerb JC (1977) The effect of cholinergic drugs on [3H] acetylcholine release from slices of rat hippocampus, striatum and cortex. Brain Res 123:311–322

    Article  CAS  PubMed  Google Scholar 

  • Hall CS (1936) Emotional behavior in the rat. III. The relationship between emotionality and ambulatory activity. J Comp Physiol Psychol 22:345–352

    Article  Google Scholar 

  • Harder JA, Maclean CJ, Alder JT, Francis PT, Ridley RM (1996) The 5-HT1A antagonist, Way 100635, ameliorates the cognitive impairment induced by fornix transection in the marmoset. Psychopharmacology 127:245–254

    CAS  PubMed  Google Scholar 

  • Hardy JA, Higgins GA (1992) Alzheimer's disease: the amyloid cascade. Science 256:184–185

    Article  CAS  PubMed  Google Scholar 

  • Harkany T, O'Mahony S, Kelly JP, Soós K, Törö I, Penke B, Luíten PGM, Nyakas C, Gulya K, Leonard BE (1998) β-Amyloid(Phe(SO3H)24) 25–35 in rat nucleus basalis induces behavioral dysfunctions, impairs learning and memory and disrupts cortical cholinergic innervation. Behav Brain Res 90:133–145

    Article  CAS  PubMed  Google Scholar 

  • Harms HH, Wardeh G, Mulder AH (1979) Effects of adenosine on depolarization-induced release of various radiolabelled neurotransmitters from slices of rat corpus striatum. Neuropharmacol 18:577–580

    Article  CAS  Google Scholar 

  • Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A, Anaert W, Umans L, Lübke T, Illert AL, von Figura K, Saftig P (2002) The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for α-secretase activity in fibroblasts. Human Mol Genet 11:2615–2624

    Article  CAS  Google Scholar 

  • Harvey JA, Romano AG (1993) Harmaline-induced impairment of Pavlovian conditioning in the rabbit. J Neurosci 13:1616–1623

    CAS  PubMed  Google Scholar 

  • Hattori K, Lee H, Hurn PD, Crain BJ, Traystman RJ, DeVries AC (2000) Cognitive deficits after focal cerebral ischemia in mice. Stroke 31:1939–1944

    Article  CAS  PubMed  Google Scholar 

  • Haugabook SJ, Le T, Yager D, Zenk B, Healy BM, Eckman EA, Prada C, Younkin L, Murphy P, Pinnix I, Onstead L, Sambamurti K, Golde TE, Dickson D, Younkin SG, Eckman CB (2001) Reduction of Aβ accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin. FASEB J 15:16–18

    CAS  PubMed  Google Scholar 

  • Hefti F (1986) Nerve growth factor promotes survival of septal cholinergic neurons after fibrial transsections. J Neurosci 6:2155–2162

    CAS  PubMed  Google Scholar 

  • Hefti FF, Rosenthal A, Walicke PA, Wyatt S, Vergara G, Shelton DL, Davies AM (2006) Novel class of pain drugs based on antagonism of NGF. Trends Pharmacol Sci 27:85–91

    Article  CAS  PubMed  Google Scholar 

  • Heilbronn E (1961) Inhibition of cholinesterase by tetrahydro-aminacrin. A Chem Scand 15:1386–1390

    Article  CAS  Google Scholar 

  • Heller Brown J, Goldstein D, Masters SB (1985) The putative M1 muscarinic receptor does not regulate phosphoinositide hydrolysis. Mol Pharmacol 27:525–531

    CAS  Google Scholar 

  • Hepler DJ, Wenk G, Cribbs BL, Olton DS, Coyle JT (1985) Memory impairments following basal forebrain lesions. Brain Res 346:8–14

    Article  CAS  PubMed  Google Scholar 

  • Herrnstein RJ (1969) Method and theory in the study of avoidance. Psychol Rev 76:49–69

    Article  CAS  PubMed  Google Scholar 

  • Hess EH (1972) “Imprinting” in a natural laboratory. Scientific American 227:24–31

    Article  CAS  PubMed  Google Scholar 

  • Hestrin S, Feigold DS, Schramm M (1955) Hexose hydrolases. In: Colowick SP, Kaplan NO (eds) Methods of Enzymology, Vol. I, pp?231–257, Academic Press, New York

    Google Scholar 

  • Higgins GA, Jacobsen H (2003) Transgenic mouse models of Alzheimer's disease: phenotype and application. Behav Pharmacol 14:419–436

    CAS  PubMed  Google Scholar 

  • Higuchi M, Tomioka M, Takano J, Shirotani K, Iwata N, Masumoto H, Maki M, Itohara S, Saido TC (2005) Distinct mechanistic roles of calpain and caspases activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors. J Biol Chem 280:15229–15237

    Article  CAS  PubMed  Google Scholar 

  • Hiramatsu M, Inoue K (1999) Effects of nocistatin on nociceptin-induced impairment of learning and memory in mice. Eur J Pharmacol 367:151–155

    Article  CAS  PubMed  Google Scholar 

  • Hiramatsu M, Inoue K (2000) Improvement by low doses of nociceptin on scopolamine-induced impairment of learning and/or memory. Eur J Pharmacol 395:149–156

    Article  CAS  PubMed  Google Scholar 

  • Hirasawa K, Nishizuka Y (1985) Phosphatidylinositol turnover in receptor mechanism and signal transduction. Ann Rev Pharmacol Toxicol 25:147–170

    Article  CAS  Google Scholar 

  • Hock FJ (1987) Drug influences on learning and memory in aged animals and humans. Neuropsychobiol 17:145–160

    Article  CAS  Google Scholar 

  • Hock FJ (1993) Effects of cromakalim on sodium nitrite intoxication. In: Elsner N, Heisenberg M (eds) Gene, Brain and Behaviour. Proceedings of the 21st Göttingen Neurobiology Conference. Georg Thieme Verlag, Stuttgart, 681

    Google Scholar 

  • Hock FJ (1994) Involvement of nitric oxide-formation in the action of losartan (DUP 753): effects in an inhibitory avoidance model. Behav Brain Res 61:163–167

    Article  CAS  PubMed  Google Scholar 

  • Hock FJ, Gerhards HJ, Wiemer G, Stechl J, Rüger W, Urbach H (1989) Effects of the novel compound, Hoe 065, upon impaired learning and memory in rodents. Eur J Pharmacol 171:79–85

    Article  CAS  PubMed  Google Scholar 

  • Hock FJ, McGaugh JL (1985) Enhancing effects of Hoe 175 on memory in mice. Psychopharmacology 86:114–117

    Article  CAS  PubMed  Google Scholar 

  • Hogg RC, Bertrand D (2004) Nicotine acetylcholine receptors as drug targets. Curr Drug Targets CNS Neurol Disord 3:123–130

    Article  CAS  PubMed  Google Scholar 

  • Hokin LE, Hokin MR (1955) Effects of acetylcholine on the turnover of phosphoryl units in individual phospholipids of pancreas slices and brain cortex slices. Biochem Biophys Acta 18:102–110

    Article  CAS  PubMed  Google Scholar 

  • Horton CD, Qi Y, Chikaraishi D, Wang JKT (2001) Neurotrophin-3 mediates the autocrine survival of the catecholaminergic CAD CNS neuronal cell line. J Neurochem 76:201–209

    Article  CAS  PubMed  Google Scholar 

  • Hosokawa H, Kasai R, Higuchi K, Takeshita S, Shimizu K, Hamamoto H, Honma A, Irino M, Toda K, Matsumara A, Matsushida M, Takeda T (1984) Grading score system; a method for evaluation of the degree of senescence in senescence-accelerated mouse (SAM). Mech Ageing Dev 26:91–102

    Article  CAS  PubMed  Google Scholar 

  • Hoyle E, Genn RF, Fernandes C, Stolerman IP (2006) Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task. Psychopharmacology 189:211–223

    Article  CAS  PubMed  Google Scholar 

  • Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274:99–102

    Article  CAS  PubMed  Google Scholar 

  • Huang EJ, Reichardt LF (2003) trk receptors: roles in neuronal signal transmission. Annu Rev Biochem 72:609–642

    Article  CAS  PubMed  Google Scholar 

  • Huber KM, Gallgher SM, Warren ST, Bear MF (2002) Altered syanptoc plasticity in a mouse model of fragile X mental retardation. Proc Natl Acad Sci USA 99:7746–7750

    Article  CAS  PubMed  Google Scholar 

  • Hudspeth WJ, McGaugh JL, Thomson CW (1964) Aversive and amnesic effects of electroconvulsive shock. J Comp Physiol Psychol 57:61–64

    Article  CAS  PubMed  Google Scholar 

  • Hulme EC, Birdsall NJM, Burger ASV, Mehta P (1978) The binding of antagonists to muscarinic receptors. Mol Pharmacol 14:737–750

    CAS  PubMed  Google Scholar 

  • Hurwitz HMB (1969) Discrimination learning under avoidance schedules. In: Gilbert RM, Sutherland NS (eds) Animal Discrimination Learning. Academic Press, New York, NY and London, pp 413–454

    Google Scholar 

  • Höglinger GU, Sautter J, Meyer M, Spengler C, Seiler RW, Oertel WH, Widmer HR (1998) Rat fetal ventral mesencephalon grown as a solid tissue culture: influence of culture time and BDNF treatment on dopamine neuron survival and function. Brain Res 813:313–322

    Article  PubMed  Google Scholar 

  • Hölscher C (2002) Metabotropic glutamate receptors control gating of spike transmission in the hippocampus area CA1. Pharmacol Biochem Behav 73:307–316

    Article  PubMed  Google Scholar 

  • Hölscher Ch, Anwyl R, Rowan M (1997b) Block of HFS-induced LTP in the dentate gyrus by 1S,3S-ACPD. Further evidence against LTP as a model of learning. NeuroReport 8:451–454

    Google Scholar 

  • Hölscher Ch, McGlinchey L, Anwyl R, Rowan MJ (1997a) HFS-induced long-term potentiation and LSF-induced depotentiation in area CA1 of the hippocampus are not good models for learning. Psychopharmacology 130:174–182

    Google Scholar 

  • Hölscher Ch, Rose SPR (1992) In inhibitor of nitric oxide synthesis prevents memory formation in the chick. Neurosci Lett 145:165–167

    Google Scholar 

  • Iijima K, Liu HP, Chiang AS, Hearn SA, Konsolaki M, Zhong Y (2004) Dissecting the pathological effects of human Aβ40 and Aβ42 in Drosophila: a potential model for Alzheimer's disease. Proc Natl Acad Sci USA 101:6623–6628

    Article  CAS  PubMed  Google Scholar 

  • Ikeda K, Egashira T, Yamashita J, Okoyama S (1995) Effect of vagal autotransplantation and bifemelane hydrochloride on cholinergic markers and event-related potential in rats with lesions of the nucleus basalis magnocellularis. Brain Res 688:171–183

    Article  CAS  PubMed  Google Scholar 

  • Ikonomidou C, Stefanovska V, Turki L (2000) Neuronal death enhanced by N-methyl-D-aspartate antagonists. Proc Natl Acad Sci USA 97:12885–12890

    Article  CAS  PubMed  Google Scholar 

  • Inagawa K (1994) Impairment of spatial working memory of rats in radial maze performance induced by ethylcholine mustard aziridinium picrylsulfonate (AF6P-P): Retention curve analysis. Jpn J Psychopharmacol 14:9–17

    CAS  Google Scholar 

  • Ingram KD, Spangler EL, Iijima S, Ikari H, Kuo H, Greig NH, London ED (1994b) Rodent models in memory dysfunction in Alzheimer's disease and normal aging: moving beyond the cholinergic hypothesis. Life Sci 55:2037–2049

    Article  CAS  PubMed  Google Scholar 

  • Ingram KD, Spangler EL, Iijima S, Kuo H, Bresnahan EL, Greig NH, London ED (1994a) New pharmacological strategies for cognitive enhancement using a rat model of age-related impairment. Ann NY Acad Sci 717:16–32

    Article  CAS  PubMed  Google Scholar 

  • Ishikawa K, Kubo T, Shibanoki S, Matsumoto A, Hata H, Asai S (1997) Hippocampal degeneration inducing impairment of learning in rats: Model of dementia? Behav Brain Res 83:39–44

    Google Scholar 

  • Israël M, Lesbats B (1982) Application to mammalian tissue of the chemoluminescent method for detecting acetylcholine. J Neurochem 39:248–250

    Article  PubMed  Google Scholar 

  • Itokazu N, Yamamoto K, Ouchi Y, Cyong JC (2001) Establishment of L-3,4-dihydroxyphenilalaninde-induced pharmacological dementia model mouse. Neurosci Lett 305:123–126

    Article  CAS  PubMed  Google Scholar 

  • Iversen SD (1998) Behavioural Pharmacology of Dementia. Naunyn Schmiedeberg's Arch Pharmacol 358, Suppl 2, R 371

    Google Scholar 

  • Jackson D, Stachowiak MK, Bruno JP, Zigmond MJ (1988) Inhibition of striatal acetylcholine release by endogenous serotonin. Brain Res 457:259–266

    Article  CAS  PubMed  Google Scholar 

  • James MK, Cubeddu LX (1984) Frequency-dependent muscarinic receptor modulation of acetylcholine and dopamine release from rabbit striatum. J Pharmacol Exp Ther 229:98–104

    CAS  PubMed  Google Scholar 

  • James MK, Cubeddu LX (1987) Pharmacological characterization and functional role of muscarinic autoreceptors in the rabbit striatum. J Pharmacol Exp Ther 240:203–214

    CAS  PubMed  Google Scholar 

  • Janus C, Westaway D (2001) Transgenic mouse models of Alzheimer's disease. Physiol Behav 73:873–886

    Article  CAS  PubMed  Google Scholar 

  • Jarvik ME (1964) Techniques for evaluating the effects of drugs on memory. In: Nodin JH, Siegler PE (eds) Animal and Clinical Pharmacologic Techniques in Drug Evaluation. Year Book Medical Publ. Inc.; Chicago, pp 339–347

    Google Scholar 

  • Jarvik ME, Essmann WB (1960) A simple one-trial learning situation in mice. Psychol Rep 6:290

    Article  Google Scholar 

  • Jarvik ME, Kopp R (1967) An improved one-trial learning situation in mice. Psychol Rep 21:221–224

    Article  CAS  PubMed  Google Scholar 

  • Jensen AA, Frølund B, Liljefors T, Krogsgaard-Larsen P (2005) Neuronal nicotinic acetylcholine receptors: structural relations, target identification, and therapeutic inspirations. J Med Chem 48:4705–4745

    Article  CAS  PubMed  Google Scholar 

  • Jibiki I, Wakita S, Kubota T, Kurokawa F, Fukushima T, Yamaguchi N (1993) Haloperidol-induced blockade of induction of long-term potentiation in perforant path-dentate gyrus pathway in chronically prepared rabbits. Pharmacol Biochem Behav 46:847–852

    Article  CAS  PubMed  Google Scholar 

  • Johnson-Wood K, Lee M, Motter R, Hu K, Gordon G, Barbour R, Khan K, Gordon M, Tan H, Games D, Lieberburg I, Schenk D, Seubert P, McConlogue L (1997) Amyloid precursor protein processing and Aβ42 deposition in a transgenic mouse model of Alzheimer disease. Proc Natl Acad Sci USA 94:1550–1555

    Article  CAS  PubMed  Google Scholar 

  • Jones SVP (1993) Muscarinic receptor subtypes: Modulation of ion channels. Life Sci 52:457–464

    Article  CAS  PubMed  Google Scholar 

  • Kaga K, Harrison JB, Butcher LL, Woolf NJ, Buchwald JS (1992) Cat ‘P300’ and cholinergic septohippocampal neurons: Depth recordings, lesions, and choline acetyltransferase immunohistochemistry. Neurosci Res 13:53–71

    Article  CAS  PubMed  Google Scholar 

  • Kameyama T, Nabeshima T, Kozawa T (1986) Step-down-type passive avoidance- and escape-learning method. J Pharmacol Meth 16:39–52

    Article  CAS  Google Scholar 

  • Karlin A (1991) Explorations of the nicotinic acetylcholine receptor. Harvey Lect 85:71–107

    CAS  Google Scholar 

  • Kehoe EJ, Schreurs BG, Macrae M, Gormezano I (1995) Effects of modulating tone frequency, intensity, and duration on the classically conditioned rabbit nictitating membrane response. Psychobiology 23:103–115

    Google Scholar 

  • Kelly PH, Bondolfi L, Hunziker D, Schlecht HP, Carver K, Maguire E, Abramowski D, Wiederhold KH, Sturchler-Pierrat C, Jucker M, Bergmann R, Staufenbiel M, Sommer B (2003) Progressive age-related impairment of cognitive behavior in APP23 transgenic mice. Neurobiol Aging 24:365–378

    Article  CAS  PubMed  Google Scholar 

  • Kesner R (1980) An attribute analysis of memory: the role of the hippocampus. Physiol Psychol 8:189–197

    Google Scholar 

  • Kesner R (1986) Neurobiological views of memory, In: Martinez J, Kesner R (eds) Learning and Memory, Academic Press, Inc.: Orlando, pp 399–438

    Google Scholar 

  • Kettenmann H, Grantyn R (eds) Practical electrophysiological methods. Wiley-Liss, New York, NY (1992)

    Google Scholar 

  • Kim HD, Kong FK, Cao Y, Lewis TL, Kim H, Tang DC, Fukuchi KI (2004) Immunization of Alzheimer model mice with adenovirus vectors encoding amyloid β-protein and GM-CSF reduces amyloid load in the brain. Neurosci Lett 370:218–223

    Article  CAS  PubMed  Google Scholar 

  • Kimura S, Saito H, Minami M, Togashi H, Nakamura N, Nemoto M, Parvez HS (2000) Pathogenesis of vascular dementia in stroke-prone spontaneously hypertensive rats. Toxicology 153:167–178

    Article  CAS  PubMed  Google Scholar 

  • King DL, Arendask GW (2002) Behavioral characterization of the TG2576 transgenic model of Alzheimer's disease through 19 months. Physiol Behav 75:627–642

    Article  CAS  PubMed  Google Scholar 

  • King RA, Glasser RL (1970) Duration of electroconvulsive shock-induced retrograde amnesia in rats. Physiol Behav 5:335–339

    Article  CAS  PubMed  Google Scholar 

  • Kinoshita A, Yamada K, Hayakawa T (1991) Human recombinant superoxide dismutase protects primary cultured neurons against hypoxic injury. Pathobiol 59:340–344

    Article  CAS  Google Scholar 

  • Kirkpatrick-Steger K, Vander Linden S, Gormezano I (1991) Effects of MDA on classical conditioning of the rabbit nictitating membrane response. Pharmacol Biochem Behav 39:183–189

    Article  CAS  PubMed  Google Scholar 

  • Koelle GB, Koelle FS, Friedenwald JS (1950) The effect of inhibition of specific and non-specific cholinesterases. J Pharmacol Exp Ther 100:180–191

    CAS  PubMed  Google Scholar 

  • Koh JY, Choi DW (1988) Vulnerability of cultured cortical neurons to damage by excitotoxins: Differential susceptibility of neurons containing NADPH-diaphorase. J Neurosci 8:2153–2163

    CAS  PubMed  Google Scholar 

  • Krieglstein J, Brungs H, Peruche B (1988) Cultured neurons for testing cerebroprotective drug effects in vitro. J Pharmacol Meth 20:39–46

    Article  CAS  Google Scholar 

  • Kromer LF (1987) Nerve growth factor treatment after brain injury prevents neuronal death. Science 235:214–216

    Article  CAS  PubMed  Google Scholar 

  • Kubanis P, Zornetzer SF (1981) Age-related behavioral and neurobiological changes: A review with emphasis on memory. Behav Neural Biol 31:115–172

    Article  CAS  PubMed  Google Scholar 

  • Kubota T, Jibiki I, Fukushima T, Kurokawa K, Yamaguchi N (1994) Carbamazepine-induced blockade of induction of long-term potentiation in the perforant path-dentate gyrus pathway in chronically prepared rabbits. Neurosci Lett 170:171–174

    Article  CAS  PubMed  Google Scholar 

  • Kurtz KH, Pearl J (1960) The effect of prior fear experience on acquired-drive learning. J Comp Physiol Psychol 53:201–206

    Article  CAS  PubMed  Google Scholar 

  • Köhler C, Schwarcz R (1983) Comparison of ibotenate and kainate neurotoxicity in rat brain: a histological study. Neuroscience 8:819–835

    Article  PubMed  Google Scholar 

  • Lamberty Y, Gower AJ (1990) Age-related changes in spontaneous behavior and learning in NMRI mice from maturity to middle age. Physiol Behav 47:1137–1144

    Article  CAS  PubMed  Google Scholar 

  • Landfield PW, Deadwyler SA (eds) (1988) Long-term Potentiation: From Biophysics to Behavior. Alan R. Liss, Inc., New York, NY

    Google Scholar 

  • Lannert H, Hoyer S (1998) Intracerebroventricular injection of streptozotocin causes long-term diminutions on learning and memory abilities and cerebral energy metabolism in adult rats. Behav Neurosci 112:1199–1208

    Article  CAS  PubMed  Google Scholar 

  • Lapchak PA, Araujo DM, Quirion R, Collier B (1989) Effect of chronic nicotine treatment on nicotinic autoreceptor function and N-[3H]methylcarbamylcholine binding sites in the rat brain. J Neurochem 52:483–491

    Article  CAS  PubMed  Google Scholar 

  • Larson J, Lieu T, Petchpradub V, LeDuc B, Ngo H, Rogers GA, Lynch G (1995) Facilitation of olfactory learning by a modulator of AMPA receptors. J Neurosci 15:8023–8030

    CAS  PubMed  Google Scholar 

  • Le Novere N, Corringer PJ, Changeux JP (2002) The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences. J Neurobiol 53:447–456

    Article  PubMed  CAS  Google Scholar 

  • Lebedev SV, Volodin NN, Blinov DV, Lazarenko IP, Rogatkin SO, Chekhonin VP (2003) Neurological deficit and disturbances in higher nervous activity during modeling of perinatal hypoxic-ischemic damage to the central nervous system in rat pups. Bull Exp Biol Med 136:242–245

    Article  CAS  PubMed  Google Scholar 

  • Lehman JH, Kulnane LS, Lamb BT (2003) Alterations in b-amyloid production and deposition in brain regions of two transgenic models. Neurobiol Aging 24:645–653

    Article  CAS  PubMed  Google Scholar 

  • Lennenberg E (1967) The Biological Foundations of Language. Wiley & Sons, New York, NY

    Google Scholar 

  • Lenz DE, Maxwell DM (1981) Inhibition of rat cerebrum acetylcholinesterase isozymes after acute administration of soman. Biochem Pharmacol 30:1369–1371

    Article  CAS  PubMed  Google Scholar 

  • Lenègre A, Chermat R, Avril I, Stéru L, Porsolt RD (1988) Specificity of piracetam's anti-amnesic activity in three models of amnesia in the mouse. Pharmacol Biochem Behav 29:625–629

    Article  PubMed  Google Scholar 

  • Levey AI (1996) Muscarinic acetylcholine receptor expression in memory circuits: implications for treatment of Alzheimer disease. Proc Natl Acad Sci USA 93:13541–13456

    Article  CAS  PubMed  Google Scholar 

  • Levi O, Jongen-Rtelo AL, Feldon J, Roses AD, Michaelson DM (2003) ApoE4 impairs hippocampal plasticity isoform-specifically and blocks environmental stimulation of synaptogenesis and memory. Neurobiol Dis 13:273–282

    Article  CAS  PubMed  Google Scholar 

  • Levin ED (1988) Psychopharmacological effects in the radial-arm maze. Neurosci Biobehav Rev 12:169–175

    Article  CAS  PubMed  Google Scholar 

  • Levine S, Sohn D (1969) Cerebral ischemia in infant and adult gerbils. Arch Pathol 87:315–317

    CAS  PubMed  Google Scholar 

  • Li L, Cao D, Garber DW, Kim H, Fukuchi KI (2003) Association of aortic atherosclerosis with cerebral β-amyloidosis and learning deficits in a mouse model of Alzheimer's disease. Am J Pathol 163:2155–2164

    Article  CAS  PubMed  Google Scholar 

  • Lichtenthaler SF, Haass C (2004) Amyloid at the cutting edge: activation of α-secretase prevents amyloidogenesis in an Alzheimer disease mouse model. J Clin Invest 113:1384–1387

    CAS  PubMed  Google Scholar 

  • Lien EJ (1993) Design and discovery of new drugs by stepping-up and stepping-down approaches. Prog Drug Res 40:63–189

    Google Scholar 

  • Linden AM, Vasanen J, Storvik M, Lakso M, Korpi ER, Wong G, Casttren E (2001) Uncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptors alter the mRNA expression of proteins associated with the NMDA receptor complex. Pharmacol Toxicol 88:98–105

    CAS  PubMed  Google Scholar 

  • Lindsten K, Menéndez-Benito V, Masucci MG, Dantuma NP (2003) A transgenic mouse model of the ubiquitin/proteasome system. Nat Biotechnol 21:897–902

    Article  CAS  PubMed  Google Scholar 

  • Link CD (2001) Transgenic invertebrate models of age-associated neurodegenerative diseases. Mech Ageing Dev 122:1639–1649

    Article  CAS  PubMed  Google Scholar 

  • Link CD (2005) Invertebrate models of Alzheimer's disease. Genes Brain Behav 4:147–156

    Article  CAS  PubMed  Google Scholar 

  • Link CD, Jahnson CJ, Fonte V, Paupard MC, Hall DH, Styren S, Mathis CA, Klunk WE (2001) Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34. Neurobiol Aging 22:217–226

    Article  CAS  PubMed  Google Scholar 

  • Link CD, Taft A, Kapulkin V, Duke K, Kim S, Fei Q, Wood DE, Sahagan BG (2003) Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model. Neurobiol Aging 24:397–413

    Article  CAS  PubMed  Google Scholar 

  • Losi G, Lanza M, Makovec F, Artusi R, Caselli G, Puia G (2006) Functional in vitro characterization of CR 3394: a novel voltage dependent N-methyl-D-aspartate (NMDA) receptor antagonist. Neuropharmacology 50:277–285

    Article  CAS  PubMed  Google Scholar 

  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275

    CAS  PubMed  Google Scholar 

  • Luetje CW, Patrick J (1991) Both α- and β-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors. J Neurosci 11:837–845

    CAS  PubMed  Google Scholar 

  • Luetje CW, Wada K, Rogers S, Abramson SN, Tsuji K, Heinemann S, Patrick J (1990) Neurotoxins distinguish between different neuronal nicotinic acetylcholine receptor subunit combinations. J Neurochem 55:632–640

    Article  CAS  PubMed  Google Scholar 

  • Lundy EF, Solik BS, Frank RS, Lacy PS, Combs DJ, Zelenok GB, D'Alecy LG (1986) Morphometric evaluation of brain infarcts in rats and gerbils. J Pharmacol Meth 16:201–214

    Article  CAS  Google Scholar 

  • Luthin GR, Wolfe BB (1984) Comparison of [3H]pirenzepine and [3H]quinuclidinylbenzilate binding to muscarinic cholinergic receptors in rat brain. J Pharmacol Exp Ther 228:648–655

    CAS  PubMed  Google Scholar 

  • Lynch G, Stäubli U (1991) Possible contributions of long-term potentiation to the encoding and organization of memory. Brain Res Rev 16:204–206

    Google Scholar 

  • Lát J (1973) The analysis of habituation. Acta Neurobiol Exp 33:771–789

    Google Scholar 

  • Lärkfors L, Ebendal T (1987) Highly sensitive immunoassays for β-nerve growth factor. J Immunol Meth 97:41–47

    Article  Google Scholar 

  • Magnusson O, Nilsson LB, Westerlund D (1980) Simultaneous determination of dopamine, DOPC and homovanillic acid. Direct injections of supernatants from brain tissue homogenates in a liquid chromatography-electrochemical detection system. J Chromatogr 221:237–247

    CAS  PubMed  Google Scholar 

  • Mandelkow EM, Mandelkow E (1998) Tau in Alzheimer's disease. Trends Cell Biol 8:425–427

    Article  CAS  PubMed  Google Scholar 

  • Mantione CR, Fisher A, Hanin I (1981) The AF64A-treated mouse: possible model for central cholinergic hypofunction. Science 213:579–580

    Article  CAS  PubMed  Google Scholar 

  • Markowska AL, Spangler EL, Ingram DK (1998) Behavioral assessment of the senescence-accelerated mouse (SAM P8 and R1). Physiol Behav 64:15–26

    Article  CAS  PubMed  Google Scholar 

  • Marks MJ, O'Connor MF, Artman LD, Burch JB, Collins AC (1984) Chronic scopolamine treatment and brain cholinergic function. Pharmacol Biochem Behav 20:771–777

    Article  CAS  PubMed  Google Scholar 

  • Marshall-Goodell B, Gormezano I (1991) Effects of cocaine on conditioning of the rabbit nictitating membrane response. Pharmacol Biochem Behav 39:503–507

    Article  CAS  PubMed  Google Scholar 

  • Martin JR, Moreau JL, Jenck F (1995) Amiracetam reverses memory impairment in rats. Pharmacol Res 31:133–136

    Article  CAS  PubMed  Google Scholar 

  • Maskell PD, Speder P, Newberry NR, Bermudez I (2003) Inhibition of human α7 nicotine acetylcholine receptors by open channel blockers of N-methy-D-aspartate receptors. Br J Pharmacol 140:1313–1319

    Article  CAS  PubMed  Google Scholar 

  • Matsumoto T, Oshima K, Miyamoto A, Sakurai M, Goto M, Hayashi S (1990) Image analysis of CNS neurotrophic factor effects on neuronal survival and neurite outgrowth. J Neurosci Meth 31:153–162

    Article  CAS  Google Scholar 

  • Maurice T, Phan VL, Privat A (2001) The antisense effects of sigma11) receptor agonists confirmed by in vivo antisense strategy in the mouse. Brain Res 898:113–121

    Article  CAS  PubMed  Google Scholar 

  • Maurice T, Privat A (1997) SA4503, a novel cognitive enhancer with σ1 receptor agonist properties, facilitates NMDA receptor-dependent learning in mice. Eur J Pharmacol 328:9–18

    Article  CAS  PubMed  Google Scholar 

  • Maurice T, Roman FJ, Su T-P, Privat A (1996) Beneficial effects of sigma agonists on the age-related learning impairment in the senescence-accelerated mouse (SAM). Brain Res 733:219–230

    Article  CAS  PubMed  Google Scholar 

  • Mayford M, Mansuy IM, Müller RU, Kandel ER (1997) Memory and behavior: a second generation of genetically modified mice. Curr Biol 7:R580–589

    Article  CAS  PubMed  Google Scholar 

  • Mazarati AM, Hohmann JG, Bacon A, Lu H, Sankar R, Steiner RA, Wynick D, Westerlain CG (2000) Modulation and hippocampal excitability and seizures by galanin. J Neurosci 20:6276–6281

    CAS  PubMed  Google Scholar 

  • McClearn GE (1999) Commentary: Exotic mice as models for aging research: polemic and prospectus by R. Miller et al. Neurobiol Aging 20:233–236

    Article  CAS  PubMed  Google Scholar 

  • McDonald MP, Overmier JB (1998) Present imperfect: a critical review of animal models of the mnemonic impairments in Alzheimer's disease. Neurosci Behav Rev 22:99–120

    Article  CAS  Google Scholar 

  • McEchron MD, Gormezano I (1991) Morphine's effect on differential serial compound conditioning and reflex modification of the rabbit's (Oryctolagus cuniculus) nictitating membrane response. Behav Neurosci 105:510–520

    Article  CAS  PubMed  Google Scholar 

  • McIlwain H, Rodnight R (1962) Preparing neural tissues for metabolic study in vitro. In: McIlwain H, Rodnight R (eds) Practical neurochemistry. Churchill Ltd. London, pp 109–133

    Google Scholar 

  • McIntosh CHS, Plummer DT (1973) Multiple forms of acetylcholinesterase from pig brain. Biochem J 133:655–665

    CAS  PubMed  Google Scholar 

  • McKean DB, Pearl J (1968) Avoidance box for mice. Physiol Behav 3:795–796

    Article  Google Scholar 

  • McKinney M (1993) Muscarinic receptor subtype-specific coupling to second messengers in neuronal systems. Progr Brain Res 98:333–340

    Article  CAS  Google Scholar 

  • McKinney M, Coyle JT (1991) The potential for muscarinic receptor subtype-specific pharmacotherapy for Alzheimer's disease. Mayo Clinic Proc 66:1225–1237

    Article  CAS  Google Scholar 

  • McNamara R, Skelton R (1993) The neuropharmacological and neurochemical basis of place learning in the Morris water maze. Brain Res Rev 18:33–49

    Article  CAS  PubMed  Google Scholar 

  • Middei S, Geracitano R, Caprioli A, Mercuri N, Ammassari-Teule M (2004) Preserved fronto-striatal plasticity and enhanced procedural learning in a transgenic mouse model of Alzheimer's disease overexpressing mutant hAPPswe. Learn Mem 11:447–452

    Article  PubMed  Google Scholar 

  • Miguel-Hidalgo JJ, Vecino B, Fernández-Novoa L, Álvarez A, Cacabelos R (1998) Neuroprotective role of S12024 against neurodegeneration in the rat dentate gyrus. Eur Neuropsychopharmacol 8:203–208

    Article  CAS  PubMed  Google Scholar 

  • Miller RA, Austad S, Burke D, Chrisp C, Dysko R, Galecki A, Jackson A, Monnier V (1999) Exotic mice as models for aging research: polemic ads prospectus. Neurobiol Aging 20:217–231

    Article  CAS  PubMed  Google Scholar 

  • Milner B (1972) Disorders of learning and memory after temporal lobe lesions in man. Clin Neurosurg 19:421–446

    CAS  PubMed  Google Scholar 

  • Misgeld U (1992) Hippocampal Slices. In: Kettenmann H, Grantyn R (eds) Practical electrophysiological methods. Wiley-Liss, New York, NY, pp 41–44

    Google Scholar 

  • Misztal M, Skangiel-Kramska J, Niewiadomska G, Danysz W (1996) Subchronic intraventricular infusion of quinolinic acid produces working memory impairment. A model of progressive excitotoxicity. Neuropharmacology 35:449–458

    Article  CAS  PubMed  Google Scholar 

  • Miyamoto M, Kiyota Y, Yamazaki N, Nagaoka A, Matsuo T, Nagawa Y, Takeda T (1986) Age-related changes in learning and memory in the senescence accelerated mouse (SAM). Physiol Behav 38:399–406

    Article  CAS  PubMed  Google Scholar 

  • Moechars D, Dewachter I, Lorent K, Reversé D, Baekelandt V, Naidu A, Tesseur I, Spittaels K, van den Haute C, Checler F, Godaux E, Cordell B, van Leuwen F (1999) Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem 274:6483–6492

    Article  CAS  PubMed  Google Scholar 

  • Moechars D, Lorent K, de Strooper B, Dewachter I, van Leuwen F (1996) Expression in brain of amyloid precursor protein mutated in the a-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice. EMBO J 15:1265–1274

    CAS  PubMed  Google Scholar 

  • Monaghan DT, Holets VR, Toy DW, Cotman DW (1983) Anatomical distributions of four pharmacologically distinct 3H-L-glutamate binding sites. Nature 306:176–179

    Article  CAS  PubMed  Google Scholar 

  • Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Meth 11:47–60

    Article  CAS  Google Scholar 

  • Morris R, Anderson E, Lynch G, Baudry M (1986) Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist. Nature 319:774–776

    Article  CAS  PubMed  Google Scholar 

  • Morris RGM (1981) Spatial localization does not require the presence of local cues. Learn Motiv 12:239–260

    Article  Google Scholar 

  • Morris RGM (1989) Synaptic plasticity and learning: Selective impairment in rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. J Neurosci 9:3040–3057

    CAS  PubMed  Google Scholar 

  • Mulle C, Vidal C, Benoit P, Changeux JP (1991) Existence of different subtypes of nicotinic acetylcholine receptors in the rat habenulo-interpeduncular system. J Neurosci 11:2588–2597

    CAS  PubMed  Google Scholar 

  • Muller F, Dumez Y, Massoulié J (1985) Molecular forms and solubility of acetylcholinesterase during the embryonic development of rat and human brain. Brain Res 331:295–302

    Article  CAS  PubMed  Google Scholar 

  • Munn NL (1950) Handbook of Psychological Research on the Rat. Houghton Mifflin, Boston, MA

    Google Scholar 

  • Muramatsu M, Tamaki-Ohashi J, Usuki C, Araki H, Aihara H (1988) Serotonin-2 receptor-mediated regulation of release of acetylcholine by minaprine in cholinergic nerve terminal of hippocampus of rat. Neuropharmacol 27:603–609

    Article  CAS  Google Scholar 

  • Murrell J, Farlow M, Ghetti B, Benson MD (1991) A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 254:97–99

    Article  CAS  PubMed  Google Scholar 

  • Myslivecek J (1997) Inhibitory learning and memory in newborn rats. Progr Neurobiol 53:399–430

    Article  CAS  Google Scholar 

  • Möbius HJ, Stöffler A, Graham SM (2004) Memantine hydrochloride. Pharmacological and clinical profile. Drugs Today 40:685–695

    Article  PubMed  Google Scholar 

  • Nabeshima T (1995) Trial to produce animal model of Alzheimer's disease by continuous infusion of β-amyloid protein into the rat cerebral ventricle. Jpn J Psychopharmacol 15:411–418

    CAS  Google Scholar 

  • Nabeshima T, Kozawa T, Furukawa H, Kameyama T (1986) Phencyclidine-induced retrograde amnesia in mice. Psychopharmacology 89:334–337

    Article  CAS  PubMed  Google Scholar 

  • Nachmansohn D, Rothenberg MA (1945) Studies on cholinesterase 1. On the specificity of the enzyme in nerve tissue. J Biol Chem 158:653–666

    CAS  Google Scholar 

  • Nahorski SR, Kendall DA, Batty I (1986) Receptors and phosphoinositide metabolism in the central nervous system. Biochem Pharmacol 35:2447–2453

    Article  CAS  PubMed  Google Scholar 

  • Namgung U, Valcourt E, Routtenberg A (1995) Long-term potentiation in the intact mouse hippocampus. Brain Res 689:85–92

    Article  CAS  PubMed  Google Scholar 

  • Narahashi T (1992) Overview of toxins and drugs as tools to study excitable membrane ion channels: II. Transmitter activated channels. Meth Enzymol 207:643–658Sokolovsky M, Gurwitz D, Galron R (1980) Muscarinic receptor binding in mouse brain: regulation by guanine nucleotides. Biochem Biophys Res Commun 94:487–492

    Google Scholar 

  • Netto CA, Izquierdo I (1985) On how passive is inhibitory avoidance. Behav Neural Biol 43:327–330

    Article  CAS  PubMed  Google Scholar 

  • Netto CA, Valente JT, Borges-Sobrinho JB, Lasevitz J, Tomaz CA (1991) Reversal of retrieval impairment caused by retroactive interference in a two-way active avoidance task in rats. Behav Neur Biol 55:114–122

    Article  CAS  Google Scholar 

  • Ng KT, O'Dowd BS, Rickard NS, Robinson SR, Gibbs ME, Rainey C, Zhao W-Q, Sedman GL, Hertz L (1997) Complex roles of glutamate in the Gibbs-Ng model of one-trial aversive learning in the new-born chick. Neurosci Behav Rev 21:45–54

    Article  CAS  Google Scholar 

  • Nichols CD (2006) Drosophila melanogaster neurobiology, neuropharmacology, and how the fly can inform central nervous system drug discovery. Pharmacol Ther 112:677–700

    Article  CAS  PubMed  Google Scholar 

  • Nielsen JA, Johnston CA (1982) Rapid, concurrent analysis of dopamine, 5-hydroxytryptamine, their precursors and metabolites utilizing high performance liquid chromatography with electrochemical detection: analysis of brain tissue and cerebrospinal fluid. Life Sci 31:2847–2856

    Article  CAS  PubMed  Google Scholar 

  • Nigrosh BJ, Slotnik BM, Nevin JA (1957) Olfactory discrimination, reversal learning and stimulus control in rats. J Comp Physiol Psychol 89:285–194

    Article  Google Scholar 

  • Nishino N, Fuji Y, Kondo M, Shuntoh H, Fujiwara H, Tanaka C (1987) Effects of L-Threo-3,4,-dihydroxyphenylserine on efflux of monoamines and acetylcholine in guinea pig brain. J Pharmacol Exp Ther 242:621–628

    CAS  PubMed  Google Scholar 

  • Nishiyama N, Moriguchi T, Saito H (1997) Beneficial effects of aged garlic extract on learning and memory impairment in the senescence-accelerated mouse. Exp Gerontol 32:149–160

    Article  CAS  PubMed  Google Scholar 

  • Nitta A, Itoh A, Hasegawa T, Nabeshima T (1994) β-Amyloid protein-induced Alzheimer's disease animal model. Neurosci Lett 170:63–66

    Article  CAS  PubMed  Google Scholar 

  • Nitta A, Nabeshima T (1996) Experimental techniques for developing new drugs acting on dementia. Alzheimer's disease animal model induced by β-amyloid protein. Jpn J Psychopharmacol 16:85–90

    CAS  Google Scholar 

  • Nitta A, Ogihara Y, Onishi J, Hasegawa T, Furukawa S, Nabeshima T (1997) Oral administration of propentofylline, a stimulator of nerve growth factor (NGF) synthesis, recovers cholinergic neuronal dysfunction induced by the infusion of anti-NGF antibody into the rat septum. Behav Brain Res 83:201–204

    Article  CAS  PubMed  Google Scholar 

  • Noda Y, Furukawa K, Kohayakawa H, Oka M (1995) Effects of RGH-2202 on behavioral deficits after focal cerebral ischemia in rats. Pharmacol Biochem Behav 52:695–699

    Article  CAS  PubMed  Google Scholar 

  • Nonaka R, Moroji T (1984) Quantitative autoradiography of muscarinic cholinergic receptors in the rat brain. Brain Res 296:295–303

    Article  CAS  PubMed  Google Scholar 

  • Nordberg A (1990) Pharmacological modulation of transmitter activity in Alzheimer brains – an experimental model. In: Novel Therapeutic Strategies for Dementia Diseases. Acta Neur Scand, Suppl 129:17–20

    Google Scholar 

  • Nordberg A, Winblad B (1986) Reduced number of [3H]nicotine and [3H]-acetylcholine binding sites in the frontal cortex of Alzheimer brains. Neurosci Lett 72:115–119

    Article  CAS  PubMed  Google Scholar 

  • O'Brien RD (1969) Phosphorylation and carbamylation of cholinesterase. Ann NY Acad Sci 160:204–214

    Article  PubMed  Google Scholar 

  • O'Connell MF (1980) Autoshaping and food acquisition in mice: a genetic analysis. J Comp Physiol Psychol 94:1149–1159

    Article  PubMed  Google Scholar 

  • O'Neill MJ. Murray TK, Lakics V, Visanji NP, Duty S (2002) The role of neuronal nicotinic acetylcholine receptors in acute and chronic neurodegeneration. Curr Drug Targets CNS Neurol Disord 1:399–411

    Article  Google Scholar 

  • Oberpichler-Schwenk H, Krieglstein J (1994) Primary cultures of neurons for testing neuroprotective drug effects. J Neural Transm (Suppl) 44:1–20

    CAS  Google Scholar 

  • Oddo S, Caccamo A, Kitazawa M, Tseng B, LaFerla FM (2003) Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol Aging 24:1063–1070

    Article  CAS  PubMed  Google Scholar 

  • Ogasawara T, Itoh Y, Tamura M, Mushiroi T, Ukai Y, Kise M, Kimura K (1999) Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer. Pharmacol Biochem Behav 64:41–52

    Article  CAS  PubMed  Google Scholar 

  • Ogura A, Miyamoto M, Kudo Y (1988) Neuronal death in vitro: parallelism between survivability of hippocampal neurons and sustained elevation of cytosolic Ca2+ after exposure to glutamate receptor agonist. Exp Brain Res 73:447–458

    Article  CAS  PubMed  Google Scholar 

  • Oike Y, Hata A, Mamiya T, Kaname T, Noda Y, Suzuki M, Yasue H, Nabeshima T, Araki K, Yamamura K (1999) Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism. Human Mol Gen 8:387–396

    Article  CAS  Google Scholar 

  • Olianas MC, Onali P, Neff NH, Costa E (1983) Adenylate cyclase activity of synaptic membranes from rat striatum: inhibition by muscarinic receptor agonists. Mol Pharmacol 23:393–398

    CAS  PubMed  Google Scholar 

  • Olton D, Walker J, Gage F (1978) Hippocampal connections and spatial discrimination. Brain Res 139:295–308

    Article  CAS  PubMed  Google Scholar 

  • Olton DS (1983) Memory functions and the hippocampus. In: Seifert W (ed) Neurobiology of the Hippocampus. Academic Press, London, New York, pp 335–373

    Google Scholar 

  • Olton DS, Becker J, Handelman G (1979) Hippocampus, space and memory. The Behavioral and Brain Sciences 2:313–365

    Google Scholar 

  • Olton DS, Samuelson RJ (1976) Remembrance of places passed: spatial memory in rats. J Exp Psychol An Behav Proc 2:97–116

    Article  Google Scholar 

  • Oomura Y, Sasaki K, Li A, Yoshii H, Yago H, Kimura H, Tooyama I, Hanai K, Nomura Y, Yanaihara N (1996) Protection against impairment of memory and immunoreactivity in senescence-accelerated mice by acidic fibroblast growth factor. Ann New York Acad Sci 786:337–347

    Article  CAS  Google Scholar 

  • Ophir G, Meilin S, Efrati M, Chapman J, Karussis D, Roses A, Michaelson DM (2003) Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice. Neurobiol Dis 12:56–64

    Article  CAS  PubMed  Google Scholar 

  • Oscos A, Martinez JL, McGaugh JL (1988) Effects of post-training d-amphetamine on acquisition of an appetitive autoshaped lever press response in rats. Psychopharmacology 95:132–134

    Article  CAS  PubMed  Google Scholar 

  • Otto T, Schottler F, Stäubli U, Eichenbaum H, Lynch G (1991) Hippocampus and olfactory discrimination learning: effects of entorhinal cortex lesions on olfactory learning and memory in a successive-cue go-no-go task. Behav Neurosci 105:111–119

    Article  CAS  PubMed  Google Scholar 

  • Pabreza LA, Dhawan S, Kellar KJ (1991) [3H]Cytisine binding to nicotinic cholinergic receptors in brain. Mol Pharmacol 39:9–12

    CAS  PubMed  Google Scholar 

  • Parker EM, Cubeddu LX (1986) Effects of d-amphetamine and dopamine synthesis inhibitors on dopamine and acetylcholine neurotransmission in the striatum. I. Release in the absence of vesicular transmitter stores. J Pharmacol Exp Ther 237:179–192

    CAS  PubMed  Google Scholar 

  • Parsons CG, Danysz W, Quack G (2000) Memantine and the amino-alkyl-cyclohexane MRZ 2/579 are moderate affinity uncompetitive NMDA receptor antagonists – in vitro characterization. Amino Acids 19:157–166

    Article  CAS  PubMed  Google Scholar 

  • Parsons CG, Quack G, Bresink I, Baran L, Przegalinski E, Kostowski W, Krzascik P, Hartmann S, Danysz W (1999) Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsant and motor impairment activity in vivo. Neuropharmacology 34:1239–1258

    Article  Google Scholar 

  • Parvathenani LK, Tertyshnikova S, Greco CR, Roberts SB, Robertson B, Posmantur R (2003) P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease. J Biol Chem 278:13309–13317

    Article  CAS  PubMed  Google Scholar 

  • Patil C, Singh VP, Satyanarayan PSV, Jain NK, Singh A, Kulkarni SK (2002) Protective effect of flavonoids against aging- and lipopolysaccharide-induced impairment in mice. Pharmacology 69:59–67

    Article  CAS  Google Scholar 

  • Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. 2nd Edition. Academic Press, New York

    Google Scholar 

  • Pereira EP, Hilmas C, Santos MD, Alkondon M, Maelicke A, Albuquerque EX (2002) Unconventional ligands and modulation of nicotinic receptors. J Neurobiol 53:479–500

    Article  CAS  PubMed  Google Scholar 

  • Peruche B, Ahlemeyer B, Brungs H, Krieglstein J (1990) Cultured neurons for testing antihypoxic drug effects. J Pharmacol Meth 23:63–77

    Article  CAS  Google Scholar 

  • Peruche B, Krieglstein J (1991) Neuroblastoma cells for testing neuroprotective drug effects. J Pharmacol Meth 26:139–148

    Article  CAS  Google Scholar 

  • Peterson C, Gibson GE (1982) 3,4-Diaminopyridine alters acetylcholine metabolism and behavior during hypoxia. J Pharmacol Exp Ther 222:576–582

    CAS  PubMed  Google Scholar 

  • Phinney AL, Deller T, Stalder M, Calhoun ME, Frotscher M, Sommer B, Staufenbiel M, Jucker M (1999) Cerebral amyloid induces aberrant axonal sprouting and ectopic terminal formation in amyloid precursor protein transgenic mice. J Neurosci 19:8552–8559

    CAS  PubMed  Google Scholar 

  • Picciotto MR, Zoli M, Léna C, Bessis A, Lallemand Y, Le Novère N, Vincent P, Pich EM, Brûlet P, Changeux JP (1995) Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature 374:65–67

    Article  CAS  PubMed  Google Scholar 

  • Pitts RC, Buda DR, Keith LR, Cerutti DT, Galizio M (2006) Chlordiazepoxide and dizocilpine, but not morphine, selectively impair acquisition under a novel repeated-acquisition and performance task in rats. Psychopharmacology 189:135–143

    Article  CAS  PubMed  Google Scholar 

  • Plaschke K, Yun SW, Martin E, Hoyer S, Bardenheuer HJ (1999) Interrelation between cerebral energy metabolism and behaviour in a rat model of permanent brain vessel occlusion. Brain Res 830:320–329

    Article  CAS  PubMed  Google Scholar 

  • Porsolt RD, Lenègre A, Avril I, Doumont G (1988) Antagonism by exifone, a new cognitive enhancing agent, of the amnesias induced by four benzodiazepines in mice. Psychopharmacology 95:291–297

    Article  CAS  PubMed  Google Scholar 

  • Postina R, Schroeder A, Dewachter I, Bohl J, Schmitt U, Kojro E, Prinzen C, Endres K, Hiemke C, Blessing M, Flamez P, Dequenne A, Godaux E, van Leuwen F, Fahrenholz F (2004) A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. J Clin Invest 113:1456–1464

    CAS  PubMed  Google Scholar 

  • Prehn JHM, Backhauß C, Krieglstein J (1993) Transforming growth factor-β1 prevents glutamate neurotoxicity in rat neocortical cultures and protects mouse neocortex from ischemic injury in vivo. J Cerebr Blood Flow Metab 13:521–525

    Article  CAS  Google Scholar 

  • Prehn JHM, Lippert K, Krieglstein J (1995) Are NMDA or AMPA/kainate receptor antagonists more efficacious in the delayed treatment of excitotoxic neuronal injury? Eur J Pharmacol 292:179–189

    Google Scholar 

  • Pulsinelli WA, Brierley JB (1979) A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 10:267–272

    Article  CAS  PubMed  Google Scholar 

  • Qi Y, Wang J, McMillan M, Chikaraishi D (1997) Characterization of a CNS cell line CAD, in which morphological differentiation is initiated by serum deprivation. J Neurosci 17:1217–1225

    CAS  PubMed  Google Scholar 

  • Qin M, Kang J, Smith CB (2002) Increased rates of cerebral glucose metabolism in a mouse model of fragile X mental retardation. Proc Natl Acad Sci USA 99:15738–15763

    Article  CAS  Google Scholar 

  • Quinn J, Montine T, Morrow J, Woodward WR, Kulhanek D, Eckenstein F (2003) Inflammation and cerebral amyloidosis are disconnected in an animal model of Alzheimer's disease. J Neuroimmunol 137:33–41

    Article  CAS  Google Scholar 

  • Raghavendra V, Kulkarni SK (2001) Possible antioxidant mechanism in melatonin reversal of aging and chronic ethanol-induced amnesia in plus-maze and passive avoidance memory tasks. Free Radical Biol Med 30:595–603

    Article  CAS  Google Scholar 

  • Raiteri M, Angelini F, Levi G (1974) A simple apparatus for studying the release of neurotransmitters from synaptosomes. Eur J Pharmacol 25:411–414

    Article  CAS  PubMed  Google Scholar 

  • Raiteri M, Marchi M, Maura G (1984) Release of catecholamines, serotonin, and acetylcholine from isolated brain tissue. In: Lajtha A (ed) Handbook of Neurochemistry, 2nd ed, Plenum Press New York, London, pp 431–462

    Google Scholar 

  • Raju TNK (1992) Some animal models for the study of perinatal asphyxia. Biol Neonate 62:202–214

    Article  CAS  PubMed  Google Scholar 

  • Rall JM, Mach SA, Dash PK (2003) Intrahippocampal infusion of a cyclooxygenase-2 inhibitor attenuates memory acquisition in rats. Brain Res 968:273–276

    Article  CAS  PubMed  Google Scholar 

  • Rapp PR, Rosenberg RA, Gallagher M (1987) An evaluation of spatial information processing in aged rats. Behav Neurosci 101:3–12

    Article  CAS  PubMed  Google Scholar 

  • Ravel N, Vigouroux M, Elaagouby A, Gervais R (1992) Scopolamine impairs delayed matching in an olfactory task in rats. Psychopharmacology 109:439–443

    Article  CAS  PubMed  Google Scholar 

  • Razani H, Díaz-Cabiale Z, Misane I, Wang FH, Fuxe K, Ögren SO (2001) Prolonged effects of intraventricular galanin in a 5-hydroxytryptamine1A receptor mediated function in the rat. Neurosci Lett 299:145–149

    Article  CAS  PubMed  Google Scholar 

  • Reilly JF, Games D, Rydel RE, Freedman S, Schenk D, Young WG, Morrison JH, Bloom FE (2003) Amyloid deposition in the hippocampus and entorhinal cortex: quantitative analysis in a transgenic mouse model. Proc Natl Acad Sci USA 100:4837–4842

    Article  CAS  PubMed  Google Scholar 

  • Ricceri L, Alleva E, Chiarotti F, Calamandrei G (1996) Nerve growth factor affects passive avoidance learning and retention in developing mice. Brain Res Bull 39:219–226

    Article  CAS  PubMed  Google Scholar 

  • Richardson IW, Szerb JC (1974) The release of labelled acetylcholine and choline from cerebral cortical slices stimulated electrically. Br J Pharmacol 52:499–507

    Article  CAS  PubMed  Google Scholar 

  • Richardson JC, Kendal CE, Anderson R, Priest F, Gower E, Soden P, Gray R, Topps S, Howlett DR, Lavender D, Clarke NJ, Barnes JC, Haworth R, Stewart MG, Rupniak HT (2003) Ultrastructural and behavioural changes precede amyloid deposition in a transgenic model of Alzheimer's disease. Neuroscience 122:213–228

    Article  CAS  PubMed  Google Scholar 

  • Rickard NS, Kowadlo N, Gibbs ME (2001) Effect of Ginkgo biloba extract, EGb 761, on memory formation in day-old chicks. Pharmacol Biochem Behav 69:351–358

    Article  CAS  PubMed  Google Scholar 

  • Rickard NS, Ng KT, Gibbs ME (1994) A nitric oxide agonist stimulates consolidation of long-term memory in 1-day old chick. Behav Neurosci 108:640–644

    Article  CAS  PubMed  Google Scholar 

  • Rieger F, Vigny M (1976) Solubilization and physicochemical characterization of rat brain acetylcholinesterase: development and maturation of its molecular forms. J Neurochem 27:121–129

    Article  CAS  PubMed  Google Scholar 

  • Ringdahl B, Jenden DJ (1983) Minireview: Pharmacological properties of oxotremorine and its analogs. Life Sci 32:2401–2413

    Article  CAS  PubMed  Google Scholar 

  • Robinson GB, Port RL, Stillwell EJ (1993) Latent inhibition of the classically conditioned rabbit nictitating membrane response is unaffected by the NMDA antagonist MK801. Psychobiology 21:120–124

    CAS  Google Scholar 

  • Robinson S (1983) Effect of 5-HT-lesions on cholinergic neurons in the hippocampus, cortex and striatum. Life Sci 32:345–353

    Article  CAS  PubMed  Google Scholar 

  • Rockenstein EM, McConlogue L, Tan H, Power M, Masliah E, Mucke L (1995) Levels and alternative splicing of amyloid β protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease. J Biol Chem 270:28257–28267

    Article  CAS  PubMed  Google Scholar 

  • Roder JK, Roder JC, Gerlai R (1996) Memory and the effect of cold shock in the water maze in S100β transgenic mice. Physiol Behav 60:611–615

    Article  CAS  PubMed  Google Scholar 

  • Rodrigo J, Fernández-Vizarra P, Castro-Blanco S, Bentura ML, Nieto M, Gómmez-Isla T, Martínez-Murillo R, Martínez A, Serrano J, Fernández AP (2004) Nitric oxide in the cerebral cortex of amyloid-precursor protein (SW) Tg2576 transgenic mice. Neuroscience 128:73–89

    Article  CAS  PubMed  Google Scholar 

  • Role LW (1992) Diversity in primary structure and function of neuronal nicotinic acetylcholine receptor channels. Curr Opin Neurobiol 2:254.262

    Google Scholar 

  • Roman F, Han D, Baudry M (1989) Effects of two ACTH analogs on successive odor discrimination learning in rats. Peptides 10:303–307

    Article  CAS  PubMed  Google Scholar 

  • Roman FS, Simonetto I, Soumireu-Mourat B (1993) Learning and memory of odor-reward association: selective impairment following horizontal diagonal band lesions. Behav Neurosci 107:72–81

    Article  CAS  PubMed  Google Scholar 

  • Romano AG, Harvey JA (1993) Enhanced learning following a single, acute dose of MDA. Pharmacol Biochem Behav 44:965–969

    Article  CAS  PubMed  Google Scholar 

  • Roohey T, Raju TN, Moustogiannis AN (1997) Animal models for the study of perinatal hypoxic-ischemic encephalopathy: a critical analysis. Early Hum Dev 47:115–146

    Article  CAS  PubMed  Google Scholar 

  • Rose SPR, Stewart MG (1999) Cellular correlates of stages of memory formation in the chick following passive avoidance training. Behav Brain Res 98:237–243

    Article  CAS  PubMed  Google Scholar 

  • Rothe G, Oser A, Valet G (1988) Dihydrorhodamine 123: a new flow cytometric indicator for respiratory burst activity in neutrophil granulocytes. Naturwissensch 75:354–355

    Article  CAS  Google Scholar 

  • Rothe G, Valet G (1994) Flow cytometric assays of oxidative burst activity in phagocytes. Meth Enzymol 233:539–548

    Article  CAS  PubMed  Google Scholar 

  • Rush DK, Streit K (1992) Memory modulation with peripherally acting cholinergic drugs. Psychopharmacology 106:375–382

    Article  CAS  PubMed  Google Scholar 

  • Röltgen DP, Schneider JS (1994) Task persistence and learning ability in normal and chronic low dose MPTP-treated monkeys. Behav Brain Res 60:115–124

    Article  Google Scholar 

  • Saijoh K, Fujiwara H, Tanaka C (1985a) Influence of hypoxia on release and uptake of neurotransmitters in guinea pig striatal slices: Dopamine and acetylcholine. Jpn J Pharmacol 39:529–539

    Article  CAS  PubMed  Google Scholar 

  • Saijoh K, Fujiwara H, Tanaka C (1985b) Influence of hypoxia on release and acetylation of [3H]choline in brain slices from adult and newborn guinea pigs. Neurosci Lett 58:371–374

    Article  CAS  PubMed  Google Scholar 

  • Salmi P, Samualsson J, Ahlenius S (1994) A new computer-assisted two-way avoidance conditioning equipment for rats: behavioral and pharmacological validation. J Pharmacol Toxicol Meth 32:155–159

    Article  CAS  Google Scholar 

  • Sandi C, Rose SPR (1994)Corticosteroid receptor antagonists are amnesic for passive avoidance learning in day-old chicks. Eur J Neurosci 6:1292–1297

    Article  CAS  PubMed  Google Scholar 

  • Sara SJ, Devauges V (1989) Idazoxan, an α-2 antagonist, facilitates memory retrieval in the rat. Behav Neural Biol 51:401–411

    Article  CAS  PubMed  Google Scholar 

  • Saragovi HU, Gehring K (2000) Development of pharmacological agents for targeting neurotrophins and their receptors. Trends Pharmacol Sci 21:93–98

    Article  CAS  PubMed  Google Scholar 

  • Sargent PB (1993) The diversity of neuronal nicotinic acetylcholine receptors. Annu Rev Neurosci 16:403–443

    Article  CAS  PubMed  Google Scholar 

  • Scavio MJ, Scavio Clift P, Wills JC (1992) Post-training effects of amphetamine, chlorpromazine, ketamine, and scopolamine on the acquisition and extinction of the rabbit's conditioned membrane response. Behav Neurosci 106:900–908

    Article  CAS  PubMed  Google Scholar 

  • Schacht U, Leven M, Bäcker G (1977) Studies on brain metabolism of biogenic amines. Br J Clin Pharmacol 4:77S–87S

    Article  CAS  PubMed  Google Scholar 

  • Scheich H (1987) Neural correlates of auditory filial imprinting. J Comp Physiol A 161:605–619

    Article  CAS  PubMed  Google Scholar 

  • Schindler CW, Harvey JA (1990) Use of classical conditioning procedures in behavioral pharmacology. Drug Dev Res 20:169–187

    Article  CAS  Google Scholar 

  • Schindler U (1983) The effect of graded cerebral ischemia on brain water content and learning ability in the Mongolian gerbil. J Cerebr Blood Flow Metab 3:S335–S336

    Google Scholar 

  • Schindler U, Rush DK, Fielding S (1984) Nootropic drugs: animal models for studying effects on cognition. Drug Dev Res 4:567–576

    Article  CAS  Google Scholar 

  • Schneider JS, Kovelowski CJ (1990) Chronic exposure to low doses of MPTP. Cognitive deficits in motor asymptomatic monkeys. Brain Res 519:122–128

    Article  CAS  PubMed  Google Scholar 

  • Schneider JS, Sun ZQ, Röltgen DP (1993) Delayed matching-to-sample, object retrieval, and discrimination reversal deficits in chronic low-dose MPTP-treated monkeys. Brain Res 615:351–354

    Article  CAS  PubMed  Google Scholar 

  • Schneider JS, Sun ZQ, Röltgen DP (1994a) Effects of dopamine agonists on delayed response performance in chronic low-dose MPTP-treated monkeys. Pharmacol Biochem Behav 48:235–240

    Article  CAS  PubMed  Google Scholar 

  • Schneider JS, Sun ZQ, Röltgen DP (1994b) Effects of dihydrexidine, a full dopamine D-1 receptor agonist on delayed response performance in chronic low dose MPTP-treated monkeys. Brain Res 663:140–144

    Article  CAS  PubMed  Google Scholar 

  • Schwarting RKW, Sedelis M, Hofele K, Auburger GW, Huston JP (1999) Strain-dependent recovery of open-field behavior and striatal dopamine deficiency in the mouse MPTP model of Parkinson's disease. Neurotox Res 1:41–56

    Article  CAS  PubMed  Google Scholar 

  • Scoville WB, Milner B (1957) Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry 20:11–21

    Article  CAS  PubMed  Google Scholar 

  • Sears LL, Steinmetz JE (1990) Haloperidol impairs classically conditioned nictitating membrane responses and conditioning-related cerebellar interpositus nucleus activity in rabbits. Pharmacol Biochem Behav 36:821–830

    Article  CAS  PubMed  Google Scholar 

  • Semkowa I, Schilling M, Heinrich-Noak P, Rami A, Krieglstein J (1996) Clenbuterol protects mouse cerebral cortex and rat hippocampus from ischemic damage and attenuates glutamate neurotoxicity in cultured hippocampal neurons by induction of NGF. Brain Res 711:44–54

    Article  Google Scholar 

  • Sethy VH, Francis JW, Russell RR, Ruppel PL (1988) Dual effect of N-methyl-N-(1-methyl-4-pyrrolidino)-2-butyl) acetamide on release of (3H) acetylcholine from the rat hippocampal slices. Neuropharmacol 27:1191–1195

    Article  CAS  Google Scholar 

  • Shapiro RA, Scherer NM, Habecker BA, Subers EM, Nathanson NM (1988) Isolation, sequence and functional expression of the mouse M1 muscarinic acetylcholine receptor gene. J Biol Chem 263:18397–18403

    CAS  PubMed  Google Scholar 

  • Sharma M, Gupta YK (2000) Intracerebroventricular injection of streptozotocin in rats produces both oxidative stress and cognitive impairment. Life Sci 68:1021–1029

    Article  Google Scholar 

  • Sharma M, Gupta YK (2002) Chronic treatment with trans resveratrol prevents intracerebroventicular streptozotocin induced cognitive impairment and oxidative stress in rats. Life Sci 71:2487–2498

    Article  Google Scholar 

  • Shimada A (1999) Age-dependent cerebral atrophy and cognitive dysfunction in SAMP10 mice. Neurobiol Aging 20:125–136

    Article  CAS  PubMed  Google Scholar 

  • Shimohama S, Taniguchi T, Fujiwara M, Kameyama M (1986) Changes in nicotinic and muscarinic cholinergic receptors in Alzheimer-type dementia. J Neurochem 46:288–293

    Article  CAS  PubMed  Google Scholar 

  • Shinoda I, Furukawa Y, Furukawa S (1990) Stimulation of nerve growth factor synthesis/secretion by propentofylline in cultured mouse astroglial cells. Biochem Pharmacol 39:1813–1816

    Article  CAS  PubMed  Google Scholar 

  • Shinpo K, Kikuchi S, Morikawa F, Tashiro K (1999) Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons. Brain Res 819:170–173

    Article  CAS  PubMed  Google Scholar 

  • Shu X-Q; Mendell M (1999) Neurotrophins and hyperalgesia. Proc Natl Acad Sci 96:7693–7696

    Article  Google Scholar 

  • Shulman JM, Feany MB (2003) Genetic modifiers of taupathy in Drosophila. Genetics 165:1233–1242

    CAS  PubMed  Google Scholar 

  • Sidman M, Fletcher FG (1968) A demonstration of autoshaping in monkeys. J Exp Anal Behav 11:307–309

    Article  CAS  PubMed  Google Scholar 

  • Siegel S (1969) Discrimination overtraining and shift behavior. In: Gilbert RM, Sutherland NS (eds) Animal Discrimination Learning. Academic Press, New York, NY and London, pp 187–213

    Google Scholar 

  • Silva AJ, Stevens CF, Tonegawa S, Wang Y (1992) Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science 257:201–206

    Article  CAS  PubMed  Google Scholar 

  • Silverman P (1978) Conditioned avoidance of aversive stimuli. In: Animal behaviour in the laboratory. Chapman and Hall, London, pp 204–219

    Google Scholar 

  • Sivam SP, Norris JC, Lim DK, Hoskins B, Ho IK (1983) Effect of acute and chronic cholinesterase inhibition with diisopropylfluorophosphate on muscarinic, dopamine, and GABA receptors in the rat striatum. J Neurochem 40:1414–1422

    Article  CAS  PubMed  Google Scholar 

  • Skovronsky DM, Zhang B, Kung MP, Kung HF, Trojanowski JQ, Lee VMY (2000) In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 97:7609–7614

    Article  CAS  PubMed  Google Scholar 

  • Smit AB, Brejc K, Syed N, Sixma TK (2003) Structure and function of ACHBP, homologue of the ligand-binding domain of the nicotinic acetylcholine receptor. Ann NY Acad Sci 998:81–92

    Article  CAS  PubMed  Google Scholar 

  • Smith CP, Huger FP (1983) Effect of zinc on [3H]-QNB displacement by cholinergic agonists and antagonists. Biochem Pharmacol 32:377–380

    Article  CAS  PubMed  Google Scholar 

  • Smith CP, Huger FP, Petko W, Kongsamut S (1994a) HP 749 enhances calcium-dependent release of [3H]norepinephrine from rat cortical slices and synaptosomes. Neurochem Res 19:1265–1270

    Article  CAS  PubMed  Google Scholar 

  • Smith CP, Petko WW, Kongsamut S, Roehr JE, Effland RC, Klein JT, Huger FP (1994b) Mechanisms for the increase in electrically stimulated [3H]norepinephrine release from rat cortical slices by N-(n-propyl)-N-(4-pyridinyl)-1H-indol-1-amine. Drug Dev Res 32:13–18

    Article  CAS  Google Scholar 

  • Sobolevsky A, Koshelev S (1998) Two blocking sites of amino-adamantane derivatives in open N-methyl-D-aspartate channels. Biophys J 74:1305–1319

    Article  CAS  PubMed  Google Scholar 

  • Sobolevsky AI (1999) Two-component blocking kinetics of open NMDA channels by organic cations. Biochim Biophys Acta 1416:69–91

    Article  CAS  PubMed  Google Scholar 

  • Sobolevsky AI, Koshelev SD, Khodorov BI (1998) Interaction of memantine and adamantine with agonist-unbound NMDA-receptor channels in acutely isolated rat hippocampal neurons. J Physiol (Lond) 512:47–60

    Article  CAS  Google Scholar 

  • Sobolevsky AI, Koshelev SG, Khodorov BI (1999) Probing of NMDA channels with fast blockers. J Neurosci 19:10611–1626

    CAS  PubMed  Google Scholar 

  • Socci DJ, Crandall BM, Arendash GW (1995) Chronic antioxidant treatment improves cognitive performance of aged rats. Brain Res 693:88–94

    Article  CAS  PubMed  Google Scholar 

  • Solomon PR, Barth CL, Wood MS, Velazquez E, Groccia-Ellison ME, Yang B-Y (1995a) Age-related deficits in retention of classically conditioned nictitating membrane responses in rabbits. Behav Neurosci 109:18–23

    Article  CAS  PubMed  Google Scholar 

  • Solomon PR, Beal MF, Pendlebury WW (1988) Age-related disruption of classical conditioning: A model systems approach to age-related memory disorders. Neurobiol Aging 9:935–946

    Article  Google Scholar 

  • Solomon PR, Groccia-Ellison ME (1996) Classic conditioning in aged rabbits: delay, trace, and long delay conditioning. Behav Neurosci 110:427–435

    Article  CAS  PubMed  Google Scholar 

  • Solomon PR, Wood MS, Groccia-Ellison ME, Yang B-Y, Fanelli RJ, Mervis RF (1995b) Nimodipine facilitates retention of the classically conditioned nictitating membrane response in aged rabbits over long retention intervals. Neurobiol Aging 16:791–796

    Article  CAS  PubMed  Google Scholar 

  • Sommer B (2002) Alzheimer's disease and the amyloid cascade hypothesis. Curr Opin Pharmacol 2:87–92

    Article  CAS  PubMed  Google Scholar 

  • Song C, Earley B, Leonard BE (1997) Effect of chronic treatment with piracetam and tacrine on some changes caused by thymectomy in the rat brain. Pharmacol Biochem Behav 56:697–704

    Article  CAS  PubMed  Google Scholar 

  • Sonkusare SK, Kaul CL, Ramarao P (2005) Dementia of Alzheimer's disease and other neurodegenerative disorders – memantine, a new hope. Pharmacol Res 51:1–7

    Article  CAS  PubMed  Google Scholar 

  • Sparks L, Schreurs BG (2003) Trace amounts of copper in water induce β-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease. Proc Natl Acad Sci USA 100:11065–11069

    Article  CAS  PubMed  Google Scholar 

  • Speiser Z, Amitzi-Sonder J, Gitter S, Cohen S (1988) Behavioral differences in the developing rat following postnatal anoxia or postnatally injected AF-64A, a cholinergic neurotoxin. Behav Brain Res 30:89–94

    Article  CAS  PubMed  Google Scholar 

  • Speiser Z, Katzir O, Rehavi M, Zabarski T, Cohen S (1998) Sparing of Rasagiline (TVP-1012) of cholinergic functions and behavior in the postnatal anoxia rat. Pharmacol Biochem Behav 60:387–393

    Article  CAS  PubMed  Google Scholar 

  • Speiser Z, Uziel J, Defrin-Assa R, Gitter S, Urca G (1991) Different behavioral deficits are induced by anoxia/hypoxia in neonatal and senescent rats: blockade by MK-801. Behav Brain Res 42:181–186

    Article  CAS  PubMed  Google Scholar 

  • Spignoli G, Pedata F, Giovannelli L, Banfi S, Moroni F, Pepeu G (1986) Effect of oxiracetam and piracetam on central cholinergic mechanisms and active-avoidance acquisition. Clin Neuropharmacol 9:S39–S47

    CAS  PubMed  Google Scholar 

  • Spowart-Manning L, van der Staay FJ (2005) Spatial discrimination deficits by excitotoxic lesions in the Morris water escape task. Behav Brain Res 156:269–276

    Article  CAS  PubMed  Google Scholar 

  • Stadler S, Nesselhut T (1986) Simple and rapid measurement of acetylcholine and choline by HPLC and enzymatic-electrochemical detection. Neurochem Int 9:127–129

    Article  CAS  PubMed  Google Scholar 

  • Stamatakis A, Stewart MG, Dermon CR (1998) Passive avoidance learning involves α2-noradrenergic receptors in a day old chick. NeuroReport 9:1679–1683

    Article  CAS  PubMed  Google Scholar 

  • Stancheva S, Papazova M, Alova L, Lazarova-Bakarova M (1993) Impairment of learning and memory in shuttle-box trained rats neonatally injected with 6-hydroxydopamine. Effect of nootropic drugs. Acta Physiol Pharmacol Bulg 19:77–82

    CAS  PubMed  Google Scholar 

  • Staubli U, Huston JP (1978) Up-hill avoidance: A new passive avoidance task. Physiol Behav 21:775–776

    Google Scholar 

  • Steckler T, Andrews JS, Marten P, Turner JD (1993) Effects of NBM lesions with two neurotoxins on spatial memory and autoshaping. Pharmacol Biochem Behav 44:877–889

    Article  CAS  PubMed  Google Scholar 

  • Steckler T, Sauvage M, Holsboer F (2000) Glucocorticoid receptor impairment enhances impulsive responding in transgenic mice performing on a simultaneous visual discrimination task. Eur J Neurosci 2559–2569

    Google Scholar 

  • Steinberg GM, Mednick ML, Maddox J, Rice R, Cramer J (1975) A hydrophobic binding site in acetylcholinesterase. J Med Chem 18:1056–1061

    Article  CAS  Google Scholar 

  • Steiner RA, Hohmann JG, Holmes A, Wrenn CC, Cadd G, Juréus A, Clifton DK, Luo M, Gutshall M, Ma SY, Mufson EJ, Crawley JN (2001) Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease. Proc Natl Acad Sci USA 98:4184–4189

    Article  CAS  PubMed  Google Scholar 

  • Stephenson RM, Andrew RJ (1994) The effects of 5-HT receptor blockade on memory formation in the chick: Possible interactions between β-adrenergic and serotoninergic systems. Pharmacol Biochem Behav 48:971–975

    Article  CAS  PubMed  Google Scholar 

  • Strayer A, Wu Z, Christen Y, Link CD, Luo Y (2003) Expression of the small heat-shock protein Hsp16–2 in Caenorhabditis elegans is suppressed by Ginkgo biloba extract EGb 761. FASEB J 17:2305–2307

    CAS  PubMed  Google Scholar 

  • Strazielle C, Sturchler-Pierrat C, Staufenbiel M, Lalonde R (2003) Regional brain cytochrome oxidase activity in β-amyloid precursor protein transgenic mice with the Swedish mutation. Neuroscience 118:1151–1163

    Article  CAS  PubMed  Google Scholar 

  • Strittmatter H, Jackisch R, Hertting G (1982) Role of dopamine receptors in the modulation of acetylcholine release in the rabbit hippocampus. Naunyn-Schmiedeberg's Arch Pharmacol 321:195–200

    Article  CAS  Google Scholar 

  • Struble RG, Cork LC, Whitehouse PJ, Price DL (1982) Cholinergic innervation in neuritic plaques. Science 216:413–414

    Article  CAS  PubMed  Google Scholar 

  • Stuchlik A, Bures J (2002) Relative contribution of allothetic and idiothetic navigation to place avoidance on stable and rotating arenas in darkness. Behav Brain Res 128:179–188

    Article  CAS  PubMed  Google Scholar 

  • Stuchlik A, Rezacova L, Vales K, Bubenikova V, Kubik S (2004) Application of a novel active allothetic place avoidance task (AAPA) in testing a pharmacological model of psychosis in rats: comparison with the Morris water maze. Neurosci Lett 366:162–166

    Article  CAS  PubMed  Google Scholar 

  • Stuchlik A, Vales K (2005) Systemic administration of MK-801, a non-competitive NMDA-receptor antagonist, elicits a behavioral deficit in rats in the Active Allothetic Place Avoidance (AAPA) task irrespectively of their intact spatial pretraining. Behav Brain Res 159:163–171

    Article  CAS  PubMed  Google Scholar 

  • Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, Ledermann B, Bürki K, Frey P, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst A, Staufenbiel M, Sommer B (1997) Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci USA 84:13287–13292

    Article  Google Scholar 

  • Stäubli U, Ivy G, Lynch G (1984) Hippocampal denervation causes rapid forgetting of olfactory information in rats. Proc Natl Acad Sci USA 81:5885–5887

    Article  PubMed  Google Scholar 

  • Summers WE, Viesselman JO, March GM, Candelora K (1981) Use of THA in treatment of Alzheimer-like dementia. Pilot study in twelve patients. Biol Psychiatry 16:145–153

    CAS  PubMed  Google Scholar 

  • Summers WK, Majovski LV, Marsh GM, Tachiki K, Kling A (1986) Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type. New Eng J Med 315:1241–1245

    Article  CAS  PubMed  Google Scholar 

  • Sun MK, Alkon DL (2004) Induced depressive behavior impairs learning an memory in rats. Neuroscience 129:129–139

    Article  CAS  PubMed  Google Scholar 

  • Sunderland T, Tariot PN, Newhouse PA (1988) Differential responsivity of mood, behavior and cognition to cholinergic agents in elderly neuropsychiatric populations. Brain Res Rev 13:371–389

    Article  Google Scholar 

  • Supavilai P, Karobath M (1985) Modulation of acetylcholine release from rat striatal slices by the GABA/benzodiazepine receptor complex. Life Sci 36:417–426

    Article  CAS  PubMed  Google Scholar 

  • Sutherland NS (1969) Outlines of a theory of visual pattern recognition in animals and man. In: Gilbert RM, Sutherland NS (eds) Animal Discrimination Learning. Academic Press, New York, NY and London, pp 385–411

    Google Scholar 

  • Swick D, Pineda JA, Foote SL (1993) Effects of systemic clonidine on auditory event-related potentials in squirrel monkeys. Brain Res Bull 33:79–86

    Article  Google Scholar 

  • Szerb JC, Hadhazy P, Dudar JC (1977) Release of [3H]-acetylcholine from rat hippocampal slices: Effect of septal lesion and of graded concentrations of muscarinic agonists and antagonists. Brain Res 128:285–291

    Article  CAS  PubMed  Google Scholar 

  • Taffe MA, Weed MR, Gutierrez T, Davis SA, Gold LH (2004) Modeling a task that is sensitive to dementia of the Alzheimer's type: individual differences in acquisition of a visuo-spatial paired-associate learning task in rhesus monkeys. Behav Brain Res 149:123–133

    Article  PubMed  Google Scholar 

  • Takeda T (1996) Senescence-accelerated mouse (SAM): With special reference to age-associated pathologies and their modulation. Jpn J Hyg 51:569–578

    Article  CAS  Google Scholar 

  • Takeda T, Hosokawa M, Higuchi K, Hosono M, Akiguchi I, Katoh H (1994) A murine model of aging, Senescence-Accelerated Mouse. Arch Gerontol Geriatr 19:185–192

    Article  CAS  PubMed  Google Scholar 

  • Takeda T, Hosokawa M, Takeshida M, Irino K, Higuchi K, Matsushita T, Tomita Y, Yasuhira K, Hamamoto H, Shimizu K, Ishii M, Yamamuro T (1981) A new murine model of accelerated senescence. Mech Ageing Dev 17:183–194

    Article  CAS  PubMed  Google Scholar 

  • Takeda T, Matsushita T, Kurozumi M, Takemura K, Higuchi K, Hosokawa M (1997) Pathobiology of the senescence-accelerated mouse (SAM). Exp Gerontol 32:117–127

    Article  CAS  PubMed  Google Scholar 

  • Tamura M, Aoki Y, Seto T, Itoh Y, Ukai Y (2001) Cerebroprotective action of Na+/Ca2+ channel blocker NS-7. II Effect on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of permanent middle cerebral artery occlusion in rats. Brain Res 890:170–176

    Article  CAS  PubMed  Google Scholar 

  • Tanaka T, Yamada K, Senzaki K, Narimatsu H, Nishimura K, Kameyama T, Nabeshima T (1998) NC-1900, an active fragment analog of arginine vasopressin, improves learning and memory deficits induced by β-amyloid protein in rats. Eur J Pharmacol 352:135–142

    Article  CAS  PubMed  Google Scholar 

  • Tanaka Y, Sakurai M, Hayashi S (1989) Effect of scopolamine and HP 029, a cholinesterase inhibitor, on long term potentiation in hippocampal slices of the guinea pig. Neurosci Lett 98:179–183

    Article  CAS  PubMed  Google Scholar 

  • Tanemura K, Akagi T, Murayama M, Kikuchi N, Murayama O, Hashikawa T, Yoshiike Y, Park JM, Matsuda K, Nakao S, Sun Y, Sato S, Yamaguchi H, Takashima A (2001) Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau. Neurobiol Dis 8:1036–1045

    Article  CAS  PubMed  Google Scholar 

  • Tanemura K, Murayama M, Akagi T, Hasikawa T, Tominaga T, Ichikawa M, Yamaguchi H, Takashima A (2002) Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J Neurosci 22:133–141

    CAS  PubMed  Google Scholar 

  • Tatebayashi Y, Miyasaka T, Chui DH, Akagi T, Mishima KI, Iwasaki K, Fujiwara M, Tanemura K, Murayama M, Ishiguro K, Planel E, Sato S, Hashikawa T, Takashima A (2002) Tau filament formation and associative memory deficit in aged mice expressing human mutant (R406W) human tau. Proc Natl Acad Sci USA 99:13896–13901

    Article  CAS  PubMed  Google Scholar 

  • Taylor P (1996) Anticholinesterase agents. In: Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9thed. McGraw-Hill, New York, pp 161–176

    Google Scholar 

  • Tchekalarova J, Pechlivanova D, Kambourova T, Matsoukas J, Georgiev V (2003) The effects of sarmesin, an angiotensin II analogue on seizure susceptibility, memory retention and nociception. Regul Pept 11:191–197

    Article  CAS  Google Scholar 

  • Tenen SS (1966) An automated one-way avoidance box for the rat. Psychosom Sci 6:407–408

    Google Scholar 

  • Teyler TJ (1980) Brain slice preparations: Hippocampus. Brain Res Bull 5:391–403

    Article  CAS  PubMed  Google Scholar 

  • Thal LJ, Fuld PA, Masur DM, Sharpless NS (1983) Oral physostigmine and lecithin improve memory in Alzheimer's disease. Ann Neurology 13:491–496

    Article  CAS  Google Scholar 

  • Thiel CM, Müller CP, Huston JP, Schwarting RKW (1999) High vs low reactivity to a novel environment: Behavioral, pharmacological and neurochemical measures. Neuroscience 93:959–962

    Article  Google Scholar 

  • Thoenen H, Barde YA (1980) Physiology of nerve growth factor. Physiol Rev 60:1284–1355

    CAS  PubMed  Google Scholar 

  • Thompson G (1983) Rodent models of learning and memory in aging research. In Walker RF, Cooper RL (eds) Experimental and Clinical Interventions in Aging. Marcel Dekker, Inc., New York and Basel, pp 261–278

    Google Scholar 

  • Thompson R (1969) Localization of the ‘visual memory system’ in the white rat. J Comp Physiol Psychol 69:1–29

    Article  PubMed  Google Scholar 

  • Thompson R, Huestis PW, Crinella FM, Yu J (1987) Further lesion studies on the neuroanatomy of mental retardation in the white rat. Neurosci Biobehav Rev 11:415–440

    Article  CAS  PubMed  Google Scholar 

  • Thorsett ED, Latimer LH (2000) Therapeutic approaches to Alzheimer's disease. Curr Opin Chem Biol 4:377–382

    Article  CAS  PubMed  Google Scholar 

  • Tienari PJ, de Strooper B, Ikonen E, Ida N, Simons M, Masters CL, Dotti CG, Bayreuther K (1996) Neuronal sorting and processing of amyloid precursor protein: Implications for Alzheimer's disease. Cold Spring Harbor Symposia on Quantitative Biology 61:575–585

    Google Scholar 

  • Tiunova A, Anokhin K, Rose SPR (1998) Two critical periods of protein and glycoprotein synthesis in memory consolidation for visual categorization learning in chicks. Learn Memory 2:401–410

    Article  Google Scholar 

  • Tiunova A, Anokhin K, Rose SPR, Mileusnic R (1996) Involvement of glutamate receptors, protein kinases, and protein synthesis in memory for visual discrimination in the young chick. Neurobiol Learn Memory 65:233–243

    Article  CAS  Google Scholar 

  • Tomaz C, Dickinson-Anson H, McGaugh JL (1992) Basolateral amygdala lesions block diazepam-induced anterograde amnesia in an inhibitory avoidance task. Proc Natl Acad Sci USA 89:3615–3619

    Article  CAS  PubMed  Google Scholar 

  • Touma C, Ambrée O, Görtz N, Keyvani K, Lewejohann L, Palme R, Paulus W, Schwarze-Eicker K, Sachser N (2004) Age- and sex-dependent development of adrenocortical hyperactivity in a transgenic mouse model of Alzheimer's disease. Neurobiol Aging 25:893–904

    Article  CAS  PubMed  Google Scholar 

  • Tremml P, Lipp HP, Müller U, Ricceri L, Wolfer DP (1998) Neurobehavioral development, adult open field exploration and swimming navigation learning in mice with a modified β-amyloid precursor protein gene. Behav Brain Res 95:65–76

    Article  CAS  PubMed  Google Scholar 

  • Trevor AJ, Gordon MA, Parker KK, Chan SL (1978) Acetylcholinesterases. Life Sci 23:1209–1220

    Article  CAS  PubMed  Google Scholar 

  • Trinchese F, Liu S, Battaglia F, Walter S, Matthews PM, Arancio O (2004) Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice. Ann Neurol 55:801–813

    Article  CAS  PubMed  Google Scholar 

  • Ukai M, Watanabe Y, Kameyana T (2001) Endorphins 1 and 2, endogenous μ-opioid receptor agonists, impair passive avoidance learning in rats. Eur J Pharmacol 421:115–119

    Article  CAS  PubMed  Google Scholar 

  • Unwin N (2003) Structure and action of the nicotinic acetylcholine receptor explored by electron microscopy. FEBS Lett 555:91–95

    Article  CAS  PubMed  Google Scholar 

  • Van Dam D, Abramowski D, Staufenbiel M, de Deyn PP (2005) Symptomatic effect of donepezil, rivastigmine, galantamine and memantine of cognitive deficits in the APP23 model. Psychopharmacology 180:177–190

    Article  CAS  PubMed  Google Scholar 

  • Van Gaalen MM, Stenzel-Poore M, Holsboer F, Steckler T (2003) Reduced attention in mice overproducing corticotrophin-releasing hormone. Behav Brain Res 142:69–79

    Article  PubMed  CAS  Google Scholar 

  • Van Leuwen F (2000) Single and multiple transgenic mice as models for Alzheimer's disease. Prog Neurobiol 61:305–312

    Article  Google Scholar 

  • Vanover KE, Barrett JE (1998) An automated learning and memory model in mice: pharmacological and behavioral evaluation of an autoshaped response. Behav Pharmacol 9:273–283

    CAS  PubMed  Google Scholar 

  • Venero C, Sandi C (1997) Effects of NMDA and AMPA receptor antagonists on corticosterone facilitation of long-term memory in the chick. Eur J Neurosci 9:1923–1928

    Article  CAS  PubMed  Google Scholar 

  • Vernalllis AB, Conroy WG, Berg DK (1993) Neurons assemble acetylcholine receptors with as many as three kinds of subunits while maintaining subunit segregation among receptor subtypes. Neuron 10:451–464

    Article  Google Scholar 

  • Volbracht C, van Beek J, Zhu C, Blomgren K, Leist M (2006) Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity. Eur J Neurosci 23:2611–2622

    Article  PubMed  Google Scholar 

  • Vorobjev VS (1991) Vibrodissociation of sliced mammalian nervous tissue. J Neurosci Methods 38:145–150

    Article  CAS  PubMed  Google Scholar 

  • Wagner J, Palfreyman M, Zraika M (1979) Determination of DOPA, dopamine, DOPAC, epinephrine, norepinephrine, α-fluoromethylDOPA, and α-difluoromethylDOPA in various tissues of mice and rats using reversed-phase ion-pair liquid chromatography with electrochemical detection. J Chromatogr 221:237–247

    Google Scholar 

  • Wagner J, Vitali P, Palfreyman MG, Zraika M, Huot S (1982) Simultaneous determination of 3,4-dihydroxyphenylalanine, 5-hydroxytryptophan, dopamine, 4-hydroxy-3-methoxyphenylalanine, norepinephrine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, serotonin, and 5-hydroxyindoleacetic acid in rat cerebrospinal fluid and brain by high-performance liquid chromatography with electrochemical detection. J Neurochem 38:1241–1254

    Article  CAS  PubMed  Google Scholar 

  • Walker CH, Mackness MI (1983) Esterases: Problems of identification and classification. Biochem Pharmacol 32:3265–3269

    Article  CAS  PubMed  Google Scholar 

  • Wan R, Diamant A, de Jong W, de Wied D (1990) Changes in heart rate and body temperature during passive avoidance behavior in rats. Physiol Behav 47:493–499

    Article  CAS  PubMed  Google Scholar 

  • Wang YP, Kawai Y, Nakashima K (1999) Rabbit P300-like potential depends on cortical muscarinic receptor activation. Neuroscience 89:423–427

    Article  CAS  PubMed  Google Scholar 

  • Watson M, Roeske WR, Yamamura HI (1982) [3H]Pirenzepine selectively identifies a high affinity population of muscarinic cholinergic receptors in the rat cerebral cortex. Life Sci 31:2019–2023

    Article  CAS  PubMed  Google Scholar 

  • Watson M, Yamamura HI, Roeske WR (1983b) A unique regulatory profile and regional distribution of [3H]pirenzepine in the rat provide evidence for distinct M1 and M2 muscarinic receptor subtypes. Life Sci 32:3001–3011

    Article  CAS  PubMed  Google Scholar 

  • Weidemann A, König G, Bunke D, Fischer P, Salbaum JM, Masters CL, Beyreuther K (1989) Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 57:115–126

    Article  CAS  PubMed  Google Scholar 

  • Welsh SE, Kachelries WJ, Romano AG, Simansky KJ, Harvey JA (1998b) Effects of LSD, ritanserin, 8-OH-DPAT, and lisuride on classical conditioning in the rabbit. Pharmacol Biochem Behav 59:469–475

    Article  CAS  PubMed  Google Scholar 

  • Welsh SE, Romano AG, Harvey JA (1998a) Effects of 5-HT (2A/2C) antagonists on associative learning in the rabbit. Psychopharmacology 137:157–163

    Article  CAS  PubMed  Google Scholar 

  • Wess J (1996) Molecular biology of muscarinic acetylcholine receptors. Crit Rev Neurobiol 10:69–99

    Article  CAS  PubMed  Google Scholar 

  • White HS, Harmsworth WL, Sofia RD, Wof HH (1995) Felbamate modulates the strychnine-insensitive receptor. Epilepsy Res 20:41–48

    Article  CAS  PubMed  Google Scholar 

  • Whitehouse PJ, Martino AM, Wagster MV, Price DL, Mayeux R, Atack JR, Kellar KJ (1988) Reductions in [3H]nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease: an autoradiographic study. Neurology 38:720–723

    Article  CAS  PubMed  Google Scholar 

  • Wiley RG, Oeltmann TN, Lappi DA (1991) Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor. Brain Res 562:149–153

    Article  CAS  PubMed  Google Scholar 

  • Willer J, Gallagher M, Graham PW, Crooks GB Jr (1992) N-methyl-D-aspartate agonist D-AVP selectively disrupts taste-potentiated odor aversion learning. Behav Neurosci 106:315–323

    Article  Google Scholar 

  • Williams LR, Varon S, Peterson GM, Wictorin K, Fischer W, Bjorklund A, Gage FH (1986) Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transsection. Proc Natl Acad Sci USA 83:9231–9235

    Article  CAS  PubMed  Google Scholar 

  • Willig F, Palacios A, Monmaur P, Mhrazi M, Laurent J, Delacour J (1987) Short-term memory, exploration and locomotor activity in aged rats. Neurobiol Aging 8:393–403

    Article  CAS  PubMed  Google Scholar 

  • Wirtz-Brugger F, Cornfeldt M, McCormack K, Szewczak M Fielding S (1987) Effect of several CNS agents on P300 in rats. Neurosci Abstr 475.13

    Google Scholar 

  • Wirtz-Brugger F, McCormack K, Szewczak M, Fielding S, Connfeldt M (1986) P300 in anesthetized rat: possible model for detecting memory-enhancing drugs. Neurosci Abstr 193.4

    Google Scholar 

  • Wisniewski HM, Ghetti T, Terry RD (1973) Neuritic (senile) plaques and filamentous changes in aged Rhesus monkeys. J Neuropathol Exp Neurol 32:566–584

    Article  CAS  PubMed  Google Scholar 

  • Woodruff-Pak DS, Chi J, Li Y-T, Pak MH, Fanelli RJ (1997) Nimodipine ameliorates impaired eyeblink classical conditioning in older rabbits in the long-delay paradigm. Neurobiol Aging 18:641–649

    Article  CAS  PubMed  Google Scholar 

  • Woodruff-Pak DS, Coffin JM, Papka M (1994a) A substituted pyrrolidinone, BMY 21502, and classical conditioning of the nictitating membrane response in young and older rabbits. Psychobiology 22:312–319

    CAS  Google Scholar 

  • Woodruff-Pak DS, Li Y-T, Kem WR (1994b) A nicotinic agonist (GTS-21), eyeblink classical conditioning, and nicotine receptor binding in rabbit brain. Brain Res 645:309–317

    Article  CAS  PubMed  Google Scholar 

  • Wozniak DF, Hartman RE, Boyle MP, Vogt SK, Brooks AR, Tenkova T, Young C, Olney JW, Muglia LJ (2004) Apoptotic neurodegeneration induced by ethanol in neonatal mice with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults. Neurobiol Dis 17:403–414

    Article  CAS  PubMed  Google Scholar 

  • Xu PT, Schmechel D, Qiu HL, Herbstreith M, Rothrock-Christian T, Eyster M, Roses AD, Gilbert JR (1999) Sialylated human apolipoprotein E (apoEs) is preferentially associated with neuron-enriched cultures from APOE transgenic mice. Neurobiol Dis 6:63–75

    Article  CAS  PubMed  Google Scholar 

  • Yagi H, Akiguchi I, Ohta A, Yagi N, Hosokawa M, Takeda T (1998) Spontaneous and artificial lesions of magnocellular reticular formation of brainstem deteriorate avoidance learning in senescence-accelerated mouse (SAM). Brain Res 791:90–98

    Article  CAS  PubMed  Google Scholar 

  • Yagi H, Katoh S, Akiguchi I, Takeda T (1988) Age-related deterioration of ability of acquisition in memory and learning in senescence accelerated mouse: SAM-P/8 as an animal model of disturbance in recent memory. Brain Res 474:86–93

    Article  CAS  PubMed  Google Scholar 

  • Yamada K, Nabeshima T (2000) Animal models of Alzheimer's disease and evaluation of anti-dementia drugs. Pharmacol Ther 88:93–113

    Article  CAS  PubMed  Google Scholar 

  • Yamada S, Isogai M, Okudaira H, Hayashi R (1983) Correlation between cholinesterase inhibition and reduction in muscarinic receptors and choline uptake by repeated diisopropylfluorophosphate administration: antagonism by physostigmine and atropine. J Pharmacol Exp Ther 226:519–525

    CAS  PubMed  Google Scholar 

  • Yamaguchi T, Suzuki M, Yamamoto M (1995) YM796, a novel muscarinic agonist, improves the impairment of learning behavior in a rat model of chronic cerebral ischemia. Brain Res 669:107–114

    Article  CAS  PubMed  Google Scholar 

  • Yamamoto M, Chikuma T, Kato T (2003) Changes in the levels of neuropeptides and their metabolic enzymes in the brain regions of nucleus basalis magnocellularis-lesioned rats. J Pharmacol Sci 92:400–410

    Article  CAS  PubMed  Google Scholar 

  • Yamaoto T, Yatsugi SI, Ohno M, Furuya Y, Kitajima I, Ueki S (1990) Minaprine improves impairment of working memory induced by scopolamine and cerebral ischemia in rats. Psychopharmacology 100:316–322

    Article  Google Scholar 

  • Yang J, He L, Wang J, Adams JD Jr (2004) Early administration of nicotinamide prevents learning and memory impairment in mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Pharmacol Biochem Behav 78:179–183

    Article  CAS  PubMed  Google Scholar 

  • Yankner BA, Shooter EM (1982) The biology and mechanism of action of nerve growth factor. Ann Rev Biochem 51:845–968

    Article  CAS  PubMed  Google Scholar 

  • Ye W-Y, Cai J-X, Wang L-M, Tang X-C (1999) Improving effects of huperizine A on spatial working memory in aged monkeys and in young adult monkeys with experimental cognitive impairment. J Pharmacol Exp Ther 288:814–819

    CAS  PubMed  Google Scholar 

  • Yonemori F, Yamada H, Yamaguchi T, Uemura A, Tamura A (1996) Spatial memory disturbances after focal cerebral ischemia in rats. J Cerebr Blood Flow Metab 16:973–980

    CAS  Google Scholar 

  • Yoneoka Y, Satoh M, Akiyama K, Sano K, Fujii Y, Tanaka R (1999) An experimental study of radiation-induced cognitive dysfunction in an adult rat model. Br J Radiol 72:1196–1201

    CAS  PubMed  Google Scholar 

  • Yu ACH, Hertz E, Hertz L (1984) Alterations in uptake and release rates for GABA, glutamate, and glutamine during biochemical maturation of highly purified cultures of cerebral neurons, a GABAergic preparation. J Neurochem 42:951–960

    Article  CAS  PubMed  Google Scholar 

  • Yu Z, Cheng G, Hu B (1997) Mechanism of colchicine impairment of learning and memory, and protective effect of CGP-36742 in mice. Brain Res 750:53–58

    Article  CAS  PubMed  Google Scholar 

  • Zahniser NR, Peris J, Dwoskin LP (1986) Modulation of neurotransmitter release: an assay for receptor function. In: Chemical and functional assay of receptor binding. Soc Neurosci, Short Course 1, Syllabus, Washington, DC, pp 73–81

    Google Scholar 

  • Zajaczkowski W, Danysz W (1997) Effects of D-cycloserine and aniracetam on spatial learning in rats with entorhinal cortex lesions. Pharmacol Biochem Behav 56:21–29

    Article  CAS  PubMed  Google Scholar 

  • Zalewska-Wiñska A, Wísniewski K (2000) Behavioural activity of (S)-3,5-DHPG, a selective agonist of group 1 metabotropic glutamate receptors. Pharmacol Res 42:239–245

    Article  PubMed  CAS  Google Scholar 

  • Zhao W, Sedman GL, Gibbs ME, Ng KT (1994) Effect of PKC inhibitors and activators on memory. Behav Brain Res 60:151–160

    Article  CAS  PubMed  Google Scholar 

  • Zhuravin IA, Dubrovskaya NM, Tumanova NL (2004) Postnatal physiological development of rats after acute prenatal hypoxia. Neurosci Behav Physiol 34:809–816

    Article  CAS  PubMed  Google Scholar 

  • Zoladz PR, Campbell AM, Park CR, Schaefer D, Danysz W, Diamond DM (2006) Enhancement of long-term spatial memory in adult rats by the noncompetitive NMDA receptor antagonists, memantine and neramexane. Pharmacol Biochem Behav 85:298–306

    Article  CAS  PubMed  Google Scholar 

  • Zong P, Gu Z, Wang X, Jiang H, Feng J, Yan Z (2003) Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease. J Biol Chem 278:26888–2696

    Article  CAS  Google Scholar 

  • Zornetzer SF, Thompson R, Rogers J (1982) Rapid forgetting in aged rats. Behav Neural Biol 36:49–60

    Article  CAS  PubMed  Google Scholar 

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Vogel, H. (2007). Drug Effects on Learning and Memory. In: Vogel, H.G. (eds) Drug Discovery and Evaluation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-70995-4_7

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