Abstract
Plasticity is the collective term used for a number of mechanisms that lead to molecular and/or structural alterations of an organism. These changes occur throughout life during learning processes, novel experiences as well as in response to injury. This chapter consists of a review of functional magnetic resonance imaging findings on plasticity phenomena occurring in response to brain injury, epilepsy, and congenital lesions. First, in a brief introduction to the phenomenon ‘plasticity’, a number of factors influencing plasticity phenomena and recovery from brain injury are discussed. Next, we discuss the occurrence of plasticity phenomena in a number of diseases. In the section on plasticity phenomena in patients with brain Tumors, both preoperative and postoperative plastic changes are considered, with a focus on the motor system. The section on plasticity phenomena in patients with epilepsy is mainly focused on the lateralization (or dominance) of language in these patients.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adcock JE, Wise RG, Oxbury JM, Oxbury SM, Matthews PM (2003) Quantitative fMRI assessment of the differences in lateralization of language-related brain activation in patients with temporal lobe epilepsy. Neuroimage 18:423–438
Alkadhi H, Kollias SS, Crelier GR, Golay X, Hepp-Reymond MC, Valavanis A (2000) Plasticity of the human motor cortex in patients with arteriovenous malformations: a functional MR imaging study. Am J Neuroradiol 21:1423–1433
Anderson VA, Catroppa C, Rosenfeld J, Haritou F, Morse SA (2000) Recovery of memory function following traumatic brain injury in pre-school children. Brain Injury 14:679–692
Baciu M, Le Bas JF, Segebarth C, Benabid AL (2003) Presurgical fMRI evaluation of cerebral reorganization and motor deficit in patients with tumors and vascular malformations. Eur J Radiol 46:139–146
Berl MM, Balsamo LM, Xu B, Moore EN, Weinstein SL, Conry JA, Pearl PL, Sachs BC, Grandin CB, Frattali C, Ritter FJ, Sato S, Theodore WH, Gaillard WD (2005) Seizure focus affects regional language networks assessed by fMRI. Neurology 65:1604–1611
Bilecen D, Seifritz E, Radu EW, Schmid N, Wetzel S, Probst R, Scheffler K (2000) Cortical reorganization after acute unilateral hearing loss traced by fMRI. Neurology 54:765–767
Binder JR, Swanson SJ, Hammeke TA, Morris GL, Mueller WM, Fischer M, Benbadis S, Frost JA, Rao SM, Haughton VM (1996) Determination of language dominance using functional MRI: a comparison with the Wada test. Neurology 46:978–984
Brazdil M, Zakopcan J, Kuba R, Fanfrdlova Z, Rektor I (2003) Atypical hemispheric language dominance in left temporal lobe epilepsy as a result of the reorganization of language functions. Epilepsy Behav 4:414–419
Briellmann RS, Labate A, Harvey AS, Saling MM, Lillywhite L, Abbott DF, Jackson GD (2005) Language lateralisation is no different between patients with temporal lobe developmental tumours and hippocampal sclerosis. Epilepsia 46:334–335
Carpentier AC, Constable RT, Schlosser MJ, de Lotbiniere A, Piepmeier JM, Spencer DD, Awad IA (2001) Patterns of functional magnetic resonance imaging activation in association with structural lesions in the rolandic region: a classification system. J Neurosurg 94:946–954
Chen R, Cohen LG, Hallett M (2002) Nervous system reorganization following injury. Neuroscience 111:761–773
Cohen LG, Weeks RA, Sadato N, Celnik P, Ishii K, Hallett M (1999) Period of susceptibility for cross-modal plasticity in the blind. Ann Neurol 45:451–460
Cramer SC, Nelles G, Benson RR, Kaplan JD, Parker RA, Kwong KK, Kennedy DN, Finklestein SP, Rosen BR (1997) A functional MRI study of subjects recovered from hemiparetic stroke. Stroke 28:2518–2527
Dehaene-Lambertz G, Dehaene S, Hertz-Pannier L (2002) Functional neuroimaging of speech perception in infants. Science 298:2013–2015
Dubois J, Hertz-Pannier L, Dehaene-Lambertz G, Cointepas Y, Le Bihan D (2006) Assessment of the early organization and maturation of infants’ cerebral white matter fiber bundles: a feasibility study using quantitative diffusion tensor imaging and tractography. Neuroimage 30:1121–1132
Duffau H (2001) Acute functional reorganisation of the human motor cortex during resection of central lesions: a study using intraoperative brain mapping. J Neurol Neurosurg Psychiatry 70:506–513
Duffau H (2005) Lessons from brain mapping in surgery for low-grade glioma: insights into associations between tumour and brain plasticity. Lancet Neurol 4:476–486
Duffau H, Gatignol P, Mandonnet E, Denvil D, Sichez N, Leroy M, Lopes M, Taillandier L, Bitar A, Sichez JP, Van Effenterre R, Capelle L (2004) Functional recovery after surgical resection of eloquent brain areas invaded by lowgrade gliomas: the use of cerebral plasticity. Neurosurgery 55:468
Elbert T, Rockstroh B (2004) Reorganization of human cerebral cortex: the range of changes following use and injury. Neuroscientist 10:129–141
Fandino J, Kollias SS, Wieser HG, Valavanis A, Yonekawa Y (1999) Intraoperative validation of functional magnetic resonance imaging and cortical reorganization patterns in patients with brain tumors involving the primary motor cortex. J Neurosurg 91:238–250
Feydy A, Carlier R, Roby-Brami A, Bussel B, Cazalis F, Pierot L, Burnod Y, Maier MA (2002) Longitudinal study of motor recovery after stroke — recruitment and focusing of brain activation. Stroke 33:1610–1617
Finger S, Wolf C (1988) The Kennard effect before Kennard — the early history of age and brain-lesions. Arch Neurol 45:1136–1142
Friston KJ, Price CJ (2001) Generative models, brain function and neuroimaging. Scand J Psychol 42:167–177
Gerloff C, Bushara K, Sailer A, Wassermann EM, Chen R, Matsuoka T, Waldvogel D, Wittenberg GF, Ishii K, Cohen LG, Hallett M (2006) Multimodal imaging of brain reorganization in motor areas of the contralesional hemisphere of well recovered patients after capsular stroke. Brain 129:791–808
Hallett M (1998) The neurophysiology of dystonia. Arch Neurol 55:601–603
Helmstaedter C, Fritz NE, Gonzalez Perez PA, Elger CE, Weber B (2006) Shift-back of right into left hemisphere language dominance after control of epileptic seizures: evidence for epilepsy driven functional cerebral organization. Epilepsia Res (in press)
Hertz-Pannier L, Chiron C, Vera P, Van de Morteele PF, Kaminska A, Bourgeois M, Hollo A, Ville D, Cieuta C, Dulac O, Brunelle F, LeBihan D (2001) Functional imaging in the work-up of childhood epilepsy. Child Nerv Syst 17:223–228
Hertz-Pannier L, Chiron C, Jambaque I, Renaux-Kieffer V, Van de Moortele PF, Delalande O, Fohlen M, Brunelle F, Le Bihan D (2002) Late plasticity for language in a child’s non-dominant hemisphere — a pre-and post-surgery fMRI study. Brain 125:361–372
Holmes GL, Gairsa JL, Chevassus-Au-Louis N, Ben-Ari Y (1998) Consequences of neonatal seizures in the rat: morphological and behavioral effects. Ann Neurol 44:845–857
Janszky J, Mertens M, Janszky I, Ebner A, Woermann FG (2006) Left-sided interictal epileptic activity induces shift of language lateralization in temporal lobe epilepsy: an fMRI study. Epilepsia 47:921–927
Johnston MV (2004) Clinical disorders of brain plasticity. Brain Devel 26:73–80
Kempermann G, Wiskott L, Gage FH (2004) Functional significance of adult neurogenesis. Curr Opin Neurobiol 14:186–191
Knecht S, Drager B, Deppe M, Bobe L, Lohmann H, Floel A, Ringelstein EB, Henningsen H (2000) Handedness and hemispheric language dominance in healthy humans. Brain 123(12):2512–2518
Kolb B, Cioe J (2000) Recovery from early cortical damage in rats, VIII. Earlier may be worse: behavioural dysfunction and abnormal cerebral morphogenesis following perinatal frontal cortical lesions in the rat. Neuropharmacology 39:756–764
Krainik A, Lehericy S, Duffau H, Cornu P, Capelle L, Menu Y, Le Bihan D, Marsault C (2001a) Functional recovery following lesion of the Supplementary Motor Area: a fMRI study. Neuroimage 13:S1206
Krainik A, Lehericy S, Duffau H, Cornu P, Nence Y, Marsault CJ (2001b) Functional recovery after lesion of the supplementary motor area: an fMRI study. Radiology 221:132
Krainik A, Lehericy S, Duffau H, Vlaicu M, Poupon F, Capelle L, Cornu P, Clemenceau S, Sahel M, Valery CA, Boch AL, Mangin JF, Le Bihan D, Marsault C (2001c) Role of the supplementary motor area in motor deficit following medial frontal lobe surgery. Neurology 57:871–878
Krainik A, Duffau H, Capelle L, Cornu P, Boch AL, Mangin JF, Le Bihan D, Marsault C, Chiras J, Lehericy S (2004) Role of the healthy hemisphere in recovery after resection of the supplementary motor area. Neurology 62:1323–1332
Krakauer JW (2005) Arm function after stroke: from physiology to recovery. Semin Neurol 25:384–395
Krings T, Reinges MHT, Thiex R, Gilsbach JM, Thron A (2001) Functional and diffusion-weighted magnetic resonance images of space-occupying lesions affecting the motor system: imaging the motor cortex and pyramidal tracts. J Neurosurg 95:816–824
Krings T, Topper R, Willmes K, Reinges MHT, Gilsbach JM, Thron A (2002) Activation in primary and secondary motor areas in patients with CNS neoplasms and weakness. Neurology 58:381–390
Kubova H, Druga R, Lukasiuk K, Suchomelova L, Haugvicova R, Jirmanova I, Pitkanen A (2001) Status epilepticus causes necrotic damage in the mediodorsal nucleus of the thalamus in immature rats. J Neurosci 21:3593–3599
Lee RG, Vandonkelaar P (1995) Mechanisms underlying functional recovery following stroke. Can J Neurol Sci 22:257–263
Liegeois F, Connelly A, Cross JH, Boyd SG, Gadian DG, Vargha-Khadem F, Baldeweg T (2004) Language reorganization in children with early-onset lesions of the left hemisphere: an fMRI study. Brain 127:1229–1236
Liu Z, Yang Y, Silveira DC, Sarkisian MR, Tandon P, Huang LT, Stafstrom CE, Holmes GL (1999) Consequences of recurrent seizures during early brain development. Neuroscience 92:1443–1454
Lledo PM, Alonso M, Grubb MS (2006) Adult neurogenesis and functional plasticity in neuronal circuits. Nature Rev Neurosci 7:179–193
Malenka RC (2003) Synaptic plasticity and AMPA receptor trafficking. Glutamate Disorders Cognit Motiv 1003:1–11
Manto M, ben Taib NO, Luft AR (2006) Modulation of excitability as an early change leading to structural adaptation in the motor cortex. J Neurosci Res 83:177–180
Martino G (2004) How the brain repairs itself: new therapeutic strategies in inflammatory and degenerative CNS disorders. Lancet Neurol 3:372–378
Muhlnickel W, Elbert T, Taub E, Flor H (1998) Reorganization of auditory cortex in tinnitus. Proc Natl Acad Sci USA 95:10340–10343
Murdoch J, Hall R (1990) Brain protection — physiological and pharmacological considerations. Part 1. The physiology of brain injury. Can J Anaesth-J Can Anesth 37:663–671
Nudo RJ (2003) Adaptive plasticity in motor cortex: implications for rehabilitation after brain injury. J Rehab Med 35:7–10
Pascual-Leone A, Amedi A, Fregni F, Merabet LB (2005) The plastic human brain cortex. Annu Rev Neurosci 28:377–401
Price CJ, Warburton EA, Moore CJ, Frackowiak RSJ, Friston KJ (2001) Dynamic diaschisis: anatomically remote and context-sensitive human brain lesions. J Cognit Neurosci 13:419–429
Prins ML, Hovda DA (2001) Mapping cerebral glucose metabolism during spatial learning: interactions of development and traumatic brain injury. J Neurotrauma 18:31–46
Rasmussen T, Milner B (1977) The role of early left-brain injury in determining lateralization of cerebral speech functions. Ann N Y Acad Sci 299:355–369
Rausch R, Walsh GO (1984) Right-hemisphere language dominance in right-handed epileptic patients. Archiv Neurol 41:1077–1080
Reinges MHT, Krings T, Rohde V, Hans FJ, Willmes K, Thron A, Gilsbach JM (2005) Prospective demonstration of short-term motor plasticity following acquired central pareses. Neuroimage 24:1248–1255
Rijntjes M (2006) Mechanisms of recovery in stroke patients with hemiparesis or aphasia: new insights, old questions and the meaning of therapies. Curr Opin Neurol 19:76–83
Satz P (1979) Test of some models of hemispheric speech organization in the left-handed and right-handed. Science 203:1131–1133
Saur D, Lange R, Baumgaertner A, Schraknepper V, Willmes K, Rijntjes M, Weiller C (2006) Dynamics of language reorganization after stroke. Brain 129:1371–1384
Schiffbauer H, Ferrari P, Rowley HA, Berger MS, Roberts TPL (2001) Functional activity within brain tumors: a magnetic source imaging study. Neurosurgery 49:1313–1320
Slavin S, Laurence S, Stein DG (1988) Another look at vicariation. In: Finger S, LeVere TE, Almli CR, Stein DG (eds) Brain injury and recovery: theoretical and controversial issues. Plenum Press, New York, pp 165–178
Springer JA, Binder JR, Hammeke TA, Swanson SJ, Frost JA, Bellgowan PSF, Brewer CC, Perry HM, Morris GL, Mueller WM (1999) Language dominance in neurologically normal and epilepsy subjects-a functional MRI study. Brain 122:2033–2045
Staudt M, Lidzba K, Grodd W, Wildgruber D, Erb M, Krageloh-Mann I (2002) Right-hemispheric organization of language following early left-sided brain lesions: functional MRI topography. Neuroimage 16:954–967
Stein DG, Finger S, Hart T (1983) Brain-damage and recovery — problems and perspectives. Behav Neural Biol 37:185–222
Sunaert S (2006) Presurgical planning for tumor resectioning. J Magn Reson Imaging 23:887–905
Teasell R (2003) Stroke recovery and rehabilitation. Stroke 34:365–366
Thirumala P, Hier DB, Patel P (2002) Motor recovery after stroke: lessons from functional brain imaging. Neurol Res 24:453–458
Thomas B, Eyssen M, Peeters R, Molenaers G, Van Hecke P, De Cock P, Sunaert S (2005) Quantitative diffusion tensor imaging in cerebral palsy due to periventricular white matter injury. Brain 128:2562–2577
Trudeau N, Poulin-Dubois D, Joanette Y (2000) Language development following brain injury in early childhood: a longitudinal case study. Intl J Lang Commun Disorders 35:227–249
Voets NL, Adcock JE, Flitney DE, Behrens TEJ, Hart Y, Stacey R, Carpenter K, Matthews PM (2006) Distinct right frontal lobe activation in language processing following left hemisphere injury. Brain 129:754–766
Wang XQ, Merzenich MM, Sameshima K, Jenkins WM (1995) Remodeling of hand representation in adult cortex determined by timing of tactile stimulation. Nature 378:71–75
Ward NS, Thompson AJ, Frackowiak RSJ (2002) Spontaneous reorganization of the motor system after stroke: a longitudinal functional magnetic resonance imaging study. Ann Neurol 52:S86–S87
Weber B, Wellmer J, Reuber M, Mormann F, Weis S, Urbach H, Ruhlmann J, Elger CE, Fernandez G (2006) Left hippocampal pathology is associated with atypical language lateralization in patients with focal epilepsy. Brain 129:346–351
Weiller C, Rijntjes M (1999) Learning, plasticity, and recovery in the central nervous system. Exp Brain Res 128:134–138
Weiller C, May A, Sach M, Buhmann C, Rijntjes M (2006) Role of functional imaging in neurological disorders. J Magn Reson Imaging 23:840–850
Woermann FG, Jokeit H, Luerding R, Freitag H, Schulz R, Guertler S, Okujava M, Wolf P, Tuxhorn I, Ebner A (2003) Language lateralization by Wada test and fMRI in 100 patients with epilepsy. Neurology 61:699–701
Yuan WH, Szaflarski JP, Schmithorst VJ, Schapiro M, Byars AW, Strawsburg RH, Holland SK (2006) fMRI shows atypical language lateralization in pediatric epilepsy patients. Epilepsia 47:593–600
Zemke AC, Heagerty PJ, Lee C, Cramer SC (2003) Motor cortex organization after stroke is related to side of stroke and level of recovery. Stroke 34:E23–E26
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Thomas, B., Sage, C., Eyssen, M., Kovacs, S., Peeters, R., Sunaert, S. (2007). Brain Plasticity and fMRI. In: Stippich, C. (eds) Clinical Functional MRI. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49976-3_9
Download citation
DOI: https://doi.org/10.1007/978-3-540-49976-3_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-24469-1
Online ISBN: 978-3-540-49976-3
eBook Packages: MedicineMedicine (R0)