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Toll-like receptors are key facilitators of innate immunity within the skin.
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Different TLRs are activated by various exogenous and endogenous ligands.
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TLR signaling provides a mechanism of activating rapid and directed immune responses in defense of the host.
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Evidence for TLR expression and function has recently been discovered in skin and neuronal tissues.
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The nervous system and specific neuromediators play a role in activation and subsequent response of the TLRs.
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Directed therapy that modifies TLR signaling may provide new avenues of treating auto-immune disease, skin cancer, and conditions of inappropriate inflammation.
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Rothschild, B., Lu, Y., Chen, H., Song, P.I., Armstrong, C.A., Ansel, J.C. (2009). Neuroinflammation and Toll-Like Receptors in the Skin. In: Granstein, R.D., Luger, T.A. (eds) Neuroimmunology of the Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-35989-0_9
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