Abstract
■ Corneal ulceration may occur in diverse types of infectious keratitis, e.g., in herpetic, bacterial, or parasitic infections
■ The diverse infectious entities can be distinguished by their clinical presentation
■ Before treatment, corneal scrapings or biopsies should be obtained for proper microbiological evaluation
■ The pathogenesis of infectious corneal ulcers includes micro-organism-related and immune-mediated factors
■ Amniotic membrane may have anti-inflammatory, antiangiogenic, and antimicrobial effects, and may promote re-epithelialization
■ An “onlay” (patch) or “inlay” (graft) technique can be used for amniotic membrane transplantation
■ Patients must be followed up closely after surgery to detect any spread of infection and failure of surgery
■ Appropriate antimicrobial medication should be given before and after surgery
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Heiligenhaus, A., Heinz, C., Schmitz, K., Tappeiner, C., Bauer, D., Meller, D. (2008). Amniotic Membrane Transplantation for the Treatment of Corneal Ulceration in Infectious Keratitis. In: Reinhard, T., Larkin, F. (eds) Cornea and External Eye Disease. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33681-5_2
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