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Transient Receptor Potential and Orai Channels in Airway Smooth Muscle Cells

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Calcium Signaling In Airway Smooth Muscle Cells

Abstract

Airway smooth muscle cells (ASMCs) are a crucial component of the airway passage. In ASMCs, an increase in intracellular calcium concentration ([Ca2+]i) acts as a key determinant of force generation, cell proliferation, and other cellular responses. [Ca2+]i is generated and controlled by numerous ion channels. Recent studies demonstrate that multiple members of transient receptor potential (TRP) channels, including TRPC1-6 and TRPV1, 2, and 4, are expressed and important for the regulation of [Ca2+]i in ASMCs. In particular, TRPC channels play an important role in the control of the resting [Ca2+]i and extracellular Ca2+ influx. Three Orai molecules, known as the pore-forming subunits of specific store-operated Ca2+ channels (SOCCs), are expressed in ASMCs. Two stromal-interacting molecule proteins (Stim1 and Stim2), which serve as the endoplasmic reticulum Ca2+ sensors and thus are the major molecular components of SOCCs, are expressed in ASMCs. Identification of TRP, Orai, and Stim molecules involved in controlling and regulating [Ca2+]i, contractility, and proliferation in ASMCs offers the exciting prospect of new and novel therapies for the treatment of airway diseases such as asthma, chronic obstructive pulmonary disease, and others.

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Authors and Affiliations

  1. Department of Pharmacology, Tongji Medical College of Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, P.R. China

    Jun-Hua Xiao

  2. Center for Cardiovascular Sciences (MC-8), Albany Medical College, 47 New Scotland Avenue, Albany, NY, 12208, USA

    Yong-Xiao Wang & Yun-Min Zheng

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  1. Jun-Hua Xiao
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Correspondence to Yun-Min Zheng .

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  1. Albany Medical College Center for Cardiovascular Sciences, Albany, New York, USA

    Yong-Xiao Wang

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Xiao, JH., Wang, YX., Zheng, YM. (2014). Transient Receptor Potential and Orai Channels in Airway Smooth Muscle Cells. In: Wang, YX. (eds) Calcium Signaling In Airway Smooth Muscle Cells. Springer, Cham. https://doi.org/10.1007/978-3-319-01312-1_3

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