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The Role of Inflammation in Leukaemia

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Inflammation and Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 816))

Abstract

Acute leukaemias are a group of malignancies characterised by the invasion of the bone marrow by immature haematopoietic precursors and differentiation arrest at various maturation steps. Multiplicity of intrinsic and extrinsic factors influences the transformation and progression of leukaemia. The intrinsic factors encompass genetic alterations of cellular pathways leading to the activation of, among others, inflammatory pathways (such as nuclear factor kappa B). The extrinsic components include, among others, the inflammatory pathways activated by the bone marrow microenvironment and include chemokines, cytokines and adhesion molecules. In this chapter, we review the role of inflammatory processes in the transformation, survival and proliferation of leukaemias, particularly the role of nuclear factor kappa B and its downstream signalling in leukaemias and the novel therapeutic strategies that exploit potentially unique properties of inflammatory signalling that offer interesting options for future therapeutic interventions.

An erratum to this chapter is available at 10.1007/978-3-0348-0837-8_18

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-0348-0837-8_18

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Authors and Affiliations

  1. Department of Haematology, Galway University Hospital, Galway, Ireland

    Janusz Krawczyk

  2. Biosciences, National University of Ireland Galway, Upper Newcastle, Galway, Ireland

    Michael O’Dwyer

  3. Sylvester Comprehensive Cancer Center, University of Miami, Miami, USA

    Ronan Swords

  4. Department of Haematology, Barts and the Royal London NHS Trust, London, UK

    Ciara Freeman

  5. Northwestern Medicine Developmental Therapeutics Institute, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, USA

    Francis J Giles

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  1. Janusz Krawczyk
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  2. Michael O’Dwyer
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  3. Ronan Swords
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  4. Ciara Freeman
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  5. Francis J Giles
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Correspondence to Francis J Giles .

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Editors and Affiliations

  1. Dept of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Bharat B. Aggarwal

  2. Dept of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Bokyung Sung

  3. Dep Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Subash Chandra Gupta

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Krawczyk, J., O’Dwyer, M., Swords, R., Freeman, C., Giles, F.J. (2014). The Role of Inflammation in Leukaemia. In: Aggarwal, B., Sung, B., Gupta, S. (eds) Inflammation and Cancer. Advances in Experimental Medicine and Biology, vol 816. Springer, Basel. https://doi.org/10.1007/978-3-0348-0837-8_13

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