Abstract
Severe chronic neutropenia (SCN) is a general term used to describe patients with blood neutrophil counts either chronically or cyclically less than 500 neutrophils per cubic millimeter (i.e., <0.5 × 109/L). Many causes for this condition are known, both hereditary and acquired diseases. The common feature is that low blood neutrophil counts predispose patients to develop fever, ulcerations along the gastrointestinal tract from the mouth to the anus, and recurrent infections.
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Acknowledgments
The authors express appreciation to the Advisory Board members and staff of the SCNIR and referring physicians, patients, and families for contributing to the data for this report. We also express appreciation to Laurie Steele and to Amgen and the NIH/NIAID (# 5R 24AI049393) for their support.
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Dale, D.C., Bolyard, A.A. (2012). rHuG-CSF for the Treatment of Severe Chronic Neutropenia. In: Molineux, G., Foote, M., Arvedson, T. (eds) Twenty Years of G-CSF. Milestones in Drug Therapy. Springer, Basel. https://doi.org/10.1007/978-3-0348-0218-5_15
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