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Acute Heart Failure pp 118–123Cite as

Reactive Oxygen Species in Heart Failure

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Abstract

A constant supply of oxygen is indispensable for cardiac viability and function. However, oxygen is also central to the generation of reactive oxygen species (ROS). Indeed, it is estimated that up to 5% of the oxygen normally consumed by tissues can be transformed into ROS. Recent studies point to crucial roles of increased ROS in the pathophysiology of heart failure.1

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References

  1. Giordano FJ. Oxygen, oxidative stress, hypoxia, and heart failure. J Clin Invest 2005;115:500–8.

    CAS  PubMed  Google Scholar 

  2. Lenaz G. Role of mitochondria in oxidative stress and ageing. Biochim Biophys Acta 1998;1366:53–67.

    Article  CAS  PubMed  Google Scholar 

  3. Meneshian A, Bulkley GB. The physiology of endothelial xanthine oxidase: from urate catabolism to reperfusion injury to inflammatory signal transduction. Microcirculation 2002;9:161–75.

    CAS  PubMed  Google Scholar 

  4. Lambeth JD. Nox Enzymes and the biology of reactive oxygen. Nat Rev Immunol 2004;4:181–89.

    Article  CAS  PubMed  Google Scholar 

  5. Heymes C, Bendall JK, Ratajczak P, et al. Increased myocardial NADPH oxidase activity in human heart failure. J Am Coll Cardiol 2003;41:2164–71.

    Article  CAS  PubMed  Google Scholar 

  6. Lefer DJ, Granger DN. Oxidative stress and cardiac disease. Am J Med 2000;109:315–23.

    Article  CAS  PubMed  Google Scholar 

  7. Hayden MR, Tyagi SC. Myocardial redox stress and remodeling in metabolic syndrome, type 2 diabetes mellitus, and congestive heart failure. Med Sci Monit 2003;9:SR35–SR52.

    CAS  PubMed  Google Scholar 

  8. Zhang X, Li SY, Brown RA, Ren J. Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress. Alcohol 2004;32:175–86.

    Article  CAS  PubMed  Google Scholar 

  9. Bendall JK, Cave AC, Heymes C, Gall N, Shah AM. Pivotal role of a gp91(phox)-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice. Circulation 2002;105:293–96.

    Article  CAS  PubMed  Google Scholar 

  10. Ceriello A, Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol 2004;24:816–23.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Cardiology, Cardiovascular Division, London, UK

    Min Zhang MD, PhD

  2. Department of Cardiology, Cardiovascular Division, King’s College London School of Medicine, London, UK

    Ajay M. Shah MD, FRCP, FMedSci

Authors
  1. Min Zhang MD, PhD
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  2. Ajay M. Shah MD, FRCP, FMedSci
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Editor information

Editors and Affiliations

  1. Department of Anesthesiology and Critical Care Medicine, Lariboisière University Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Paris, France

    Alexandre Mebazaa MD, PhD (Professor of Medicine) (Professor of Medicine)

  2. Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Mihai Gheorghiade MD, FACC (Professor of Medicine and Surgery, Associate Chief, Division of Cardiology and Chief, Cardiology Clinical Service) (Professor of Medicine and Surgery, Associate Chief, Division of Cardiology and Chief, Cardiology Clinical Service)

  3. Department of Cardiology Centre d’Investigation Clinique (CIC), INSERM U-684, Centre Hospitalier Universitaire, University Henri Poincaré, Nancy, France

    Faiez M. Zannad MD, PhD, FESC (Professor of Medicine) (Professor of Medicine)

  4. Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, NJ, USA

    Joseph E. Parrillo MD (Professor of Medicine, Chief, Department of Medicine Edward D. Viner MD Chair, Department of Medicine and Director) (Professor of Medicine, Chief, Department of Medicine Edward D. Viner MD Chair, Department of Medicine and Director)

  5. Cooper Heart Institute, Cooper University Hospital, Camden, NJ, USA

    Joseph E. Parrillo MD (Professor of Medicine, Chief, Department of Medicine Edward D. Viner MD Chair, Department of Medicine and Director) (Professor of Medicine, Chief, Department of Medicine Edward D. Viner MD Chair, Department of Medicine and Director)

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© 2008 Springer-Verlag London Limited

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Zhang, M., Shah, A.M. (2008). Reactive Oxygen Species in Heart Failure. In: Mebazaa, A., Gheorghiade, M., Zannad, F.M., Parrillo, J.E. (eds) Acute Heart Failure. Springer, London. https://doi.org/10.1007/978-1-84628-782-4_12

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  • DOI: https://doi.org/10.1007/978-1-84628-782-4_12

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-781-7

  • Online ISBN: 978-1-84628-782-4

  • eBook Packages: MedicineMedicine (R0)

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