Key Points
-
Magnesium is a major mineral which is regulated at the level of kidney, bone and intestine.
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Parathormone (PTH), calcitonin, vitamin D, estrogen and cytokines are involved in regulation of magnesium.
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Menopause is associated with various endocrine changes and also alterations in magnesium metabolism.
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Oestrogen deficiency associated with menopause causes alteration in the metabolism of magnesium at the level of kidney, bone and intestine.
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Oestrogen deficiency induces various molecular and genetic changes which affect the uptake, intracellular transport and basolateral extrusion of magnesium in kidney and intestine.
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Oestrogen deficiency in menopause, also induces alteration in maturation, differentiation, activity, lifespan and cytokine secretion of osteoblasts and osteoclasts, leading to increased bone resorption and hence alteration in the metabolism of the bone mineral—magnesium.
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Abbreviations
- PTH:
-
Parathormone
- TRPM:
-
Transient receptor potential melastatin
- TRPV:
-
Transient receptor potential vanilloid
- PCT:
-
Proximal convoluted tubule
- DCT:
-
Distal convoluted tubule
- CD:
-
Collecting duct
- ECF:
-
Extracellular fluid
- ICF:
-
Intracellular fluid
- CB:
-
Calbindin
- VDR:
-
Vitamin D receptor
- RXR:
-
Retinoid receptor
- VDRE:
-
Vitamin D responsive element
- RNA:
-
Ribonucleic acid
- DNA:
-
Deoxyribonucleic acid
- IGF:
-
Insulin like growth factor
- ER:
-
Oestrogen receptor
- KO:
-
Knockout
- GH:
-
Growth hormone
- IL:
-
Interleukin
- MCSF:
-
Macrophage colony stimulating factor
- TNF:
-
Tumour necrosis factor
- IFN:
-
Interferon
- ROS:
-
Reactive oxygen species
- REA:
-
Repressor protein of oestrogen receptor activity
- PDGF:
-
Platelet-derived growth factor
- OPG:
-
Osteoprotegerin
- RANK:
-
Receptor activator of nuclear factor kappa beta
- RANKL:
-
Receptor activator of nuclear factor kappa beta ligand
- RDA:
-
Recommended daily allowance
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Avinash, S.S., Sreekantha, Goud, B.K.M. (2013). Magnesium Metabolism in Menopause. In: Hollins Martin, C., Watson, R., Preedy, V. (eds) Nutrition and Diet in Menopause. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-373-2_16
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