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Nutrition in Infancy pp 145–151Cite as

Celiac Disease in Infants: Prevention and Dietary Treatment

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Abstract

Celiac disease (CD) is the most common malabsorption in the world, and is a major healthcare issue. It is an immune-mediated gluten-dependent enteropathy, which has a wide range of clinical manifestations and variable severity. It is triggered by the ingestion of gluten, which is found in wheat, rye, and barley, in genetically susceptible individuals. While typical clinical manifestations of CD include failure to thrive, chronic diarrhea, and anemia, a significant proportion of patients present with atypical symptoms, such as skin lesions, isolated hypertransaminasemia, dental or neurological problems [1–3]. A changing pattern in the presentation of pediatric CD, such as a more frequent diagnosis in older children, mostly presents with atypical symptoms, is reported [4]. Typical (classical) CD is more common in younger children (mainly between 6 and 18 months of age) and frequently is associated with more severe intestinal injury [5].

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References

  1. Troncone R, Ivarsson A, Szajewska H, et al. Review article: future research on coeliac disease-a position report from the European multistakeholder platform on coeliac disease (CDEUSSA). Aliment Pharmacol Ther. 2008;27:1030–43.

    Article  PubMed  CAS  Google Scholar 

  2. Farrell RJ, Kelly CP. Celiac sprue. N Engl J Med. 2002;346:180–8.

    Article  PubMed  CAS  Google Scholar 

  3. Fasano A. Clinical presentation of celiac disease in the pediatric population. Gastroenterology. 2005;128:S68–73.

    Article  PubMed  Google Scholar 

  4. Roma E, Panayiotou J, Karantana H, et al. Changing pattern in the clinical presentation of pediatric celiac disease: a 30-year study. Digestion. 2009;80:185–91.

    Article  PubMed  Google Scholar 

  5. McGowan KE, Castiglione DA, Butzner JD. The changing face of childhood celiac disease in North America: impact of serological testing. Pediatrics. 2009;124:1572–8.

    Article  PubMed  Google Scholar 

  6. Ivarsson A, Persson LA, Nystrom L, et al. Epidemic of coeliac disease in Swedish children. Acta Paediatr. 2000;89:165–71.

    Article  PubMed  CAS  Google Scholar 

  7. Greco L, Mayer M, Grimaldi M, et al. The effect of early feeding on the onset of symptoms in celiac disease. J Pediatr Gastroenterol Nutr. 1985;4:52–5.

    Article  PubMed  CAS  Google Scholar 

  8. Auricchio S, Follo D, de Ritis G, et al. Does breastfeeding protect against the development of clinical symptoms of celiac disease in children? J Pediatr Gastroenterol Nutr. 1983;2:428–33.

    Article  PubMed  CAS  Google Scholar 

  9. Peters U, Schneeweiss S, Trautwein EA, et al. A case–control study of the effect of infant feeding on celiac disease. Ann Nutr Metab. 2001;45:135–42.

    Article  PubMed  CAS  Google Scholar 

  10. Ivarsson A, Hernell O, Stenlund H, et al. Breast-feeding protects against celiac disease. Am J Clin Nutr. 2002;75:914–21.

    PubMed  CAS  Google Scholar 

  11. Norris JM, Barriga K, Hoffenberg EJ, et al. Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease. JAMA. 2005;293:2343–51.

    Article  PubMed  CAS  Google Scholar 

  12. Silano M, Agostoni C, Guandalini S. Effect of the timing of gluten introduction on the development of celiac disease. World J Gastroenterol. 2010;16:1939–42.

    Article  PubMed  CAS  Google Scholar 

  13. Akobeng AK, Ramanan AV, Buchan I, et al. Effect of breast feeding on risk of coeliac disease: a systematic review and meta-analysis of observational studies. Arch Dis Child. 2006;91:39–43.

    Article  PubMed  CAS  Google Scholar 

  14. Akobeng AK, Heler RF. Assessing the population impact of low rates of breast feeding on asthma, coeliac disease and obesity: the use of a new statistical method. Arch Dis Child. 2007;92:483–5.

    Article  PubMed  Google Scholar 

  15. D’Amico MA, Holmes J, Stavropoulos SN, et al. Presentation of pediatric celiac disease in the United States: prominent effect of breastfeeding. Clin Pediatr (Phila). 2005;44:249–58.

    Article  Google Scholar 

  16. Juto P, Meeuwisse G, Mincheva-Nilsson L. Why has coeliac disease increased in Swedish children? Lancet. 1994;343:1372.

    Article  PubMed  CAS  Google Scholar 

  17. Mitt K, Uibo O. Low cereal intake in Estonian infants: the possible explanation for the low frequency of coeliac disease in Estonia. Eur J Clin Nutr. 1998;52:85–8.

    Article  PubMed  CAS  Google Scholar 

  18. Weile B, Krasilnikoff PA. Low incidence rates by birth of symptomatic coeliac disease in a Danish population of children. Acta Paediatr. 1992;81:394–8.

    Article  PubMed  CAS  Google Scholar 

  19. Gupta R, Reddy DN, Makharia GK, et al. Indian task force for celiac disease: current status. World J Gastroenterol. 2009;15:6028–33.

    Article  PubMed  Google Scholar 

  20. Ivarsson A, Hernell O, Nystrom L, et al. Children born in the summer have an increased risk for coeliac disease. J Epidemiol Community Health. 2003;57:36–9.

    Article  PubMed  CAS  Google Scholar 

  21. Stene LC, Honeyman MC, Hoffenberg EJ, et al. Rotavirus infection frequency and risk of celiac disease in early childhood: a longitudinal study. Am J Gastroenterol. 2006;101:2333–40.

    Article  PubMed  CAS  Google Scholar 

  22. Troncone R, Auricchio S. Rotavirus and celiac disease: clues to the pathogenesis and perspectives on prevention. J Pediatr Gastroenterol Nutr. 2007;44:527–8.

    Article  PubMed  Google Scholar 

  23. Schippa S, Iebba V, Barbato M, et al. A distinctive ‘microbial signature’ in celiac pediatric patients. BMC Microbiol. 2010;10:175.

    Article  PubMed  Google Scholar 

  24. Collado MC, Calabuig M, Sanz Y. Differences between the faecal microbiota of coeliac infants and healthy controls. Curr Issues Intest Microbiol. 2007;8:9–14.

    PubMed  CAS  Google Scholar 

  25. Agostoni C, Decsi T, Fewtrell M, et al. Complementary feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2008;46:99–110.

    Article  PubMed  Google Scholar 

  26. Paveley WF. From Aretaeus to Crosby: a history of coeliac disease. BMJ. 1988;297:1646–9.

    Article  PubMed  CAS  Google Scholar 

  27. Losowsky MS. A history of coeliac disease. Dig Dis. 2008;26:112–20.

    Article  PubMed  CAS  Google Scholar 

  28. Guandalini S, Gupta P. Celiac disease: a diagnostic challenge with many facets. Clin Appl Immunol Rev. 2002;2:293–305.

    Article  Google Scholar 

  29. Niewinski MM. Advances in celiac disease and gluten-free diet. J Am Diet Assoc. 2008;108:661–72.

    Article  PubMed  Google Scholar 

  30. Garcia-Manzanares A, Lucendo AJ. Nutritional and dietary aspects of celiac disease. Nutr Clin Pract. 2011;26:163–73.

    Article  PubMed  Google Scholar 

  31. Thompson T. Thiamin, riboflavin, and niacin contents of the gluten free diet: is there cause for concern? J Am Diet Assoc. 1999;99:858–62.

    Article  PubMed  CAS  Google Scholar 

  32. Thompson T. Folate, iron, and dietary fiber contents of the gluten free diet. J Am Diet Assoc. 2000;100:1389–96.

    Article  PubMed  CAS  Google Scholar 

  33. Collin P, Maki M, Kaukinen K. Safe gluten threshold for patients with celiac disease: some patients are more tolerant than others. Am J Clin Nutr. 2007;86:260.

    PubMed  CAS  Google Scholar 

  34. Catassi C, Fabiani E, Iacono G, et al. A prospective, doubleblind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease. Am J Clin Nutr. 2007;85:160–6.

    PubMed  CAS  Google Scholar 

  35. Collin P, Maki M, Kaukinen K. It is the compliance, not milligrams of gluten, that is essential in the treatment of celiac disease. Nutr Rev. 2004;62:490.

    Article  PubMed  Google Scholar 

  36. Holm K, Maki M, Vuolteenaho N, et al. Oats in the treatment of childhood coeliac disease: a 2-year controlled trial and a long-term clinical follow-up study. Aliment Pharmacol Ther. 2006;23:1463–72.

    Article  PubMed  CAS  Google Scholar 

  37. Lundin KE, Nilsen EM, Scott HG, et al. Oats induced villous atrophy in coeliac disease. Gut. 2003;52:1649–52.

    Article  PubMed  CAS  Google Scholar 

  38. Troncone R, Auricchio R, Granata V. Issues related to gluten-free diet in coeliac disease. Curr Opin Clin Nutr Metab Care. 2008;11:329–33.

    Article  PubMed  CAS  Google Scholar 

  39. Valdes I, Garcia E, Llorente M, et al. Innovative approach to low-level gluten determination in foods using a novel sandwich enzyme-linked immunosorbent assay protocol. Eur J Gastroenterol Hepatol. 2003;15:465–74.

    Article  PubMed  CAS  Google Scholar 

  40. Stahlberg MR, Savilahti E, Siimes MA. Iron deficiency in coeliac disease is mild and it is detected and corrected by gluten-free diet. Acta Paediatr Scand. 1991;80:190–3.

    Article  PubMed  CAS  Google Scholar 

  41. Kapur G, Patwari AK, Narayan S, et al. Iron supplementation in children with celiac disease. Indian J Pediatr. 2003;70:955–8.

    Article  PubMed  Google Scholar 

  42. Hill ID, Dirks MH, Liptak GS, et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2005;40:1–19.

    Article  PubMed  Google Scholar 

  43. Briani C, Samaroo D, Alaedini A. celiac disease: from gluten to autoimmunity. Autoimmun Rev. 2008;7:644–50.

    Article  PubMed  CAS  Google Scholar 

  44. See J, Murray JA. Gluten-free diet: The medical and nutrition management of celiac disease. Nutr Clin Pract. 2006;21:1–15.

    Article  PubMed  Google Scholar 

  45. Green PHR, Stavropoulos SN, Panagi SG, et al. Characteristics of adult celiac disease in the USA: Results of a national survey. Am J Gastroenterol. 2001;96:126–31.

    Article  PubMed  Google Scholar 

  46. Reilly NR, Aguilar K, Hassid BG, et al. Celiac disease in children with normal weight and overweight: clinical features and growth outcomes following a gluten-free Diet. J Pediatr Gastroenterol Nutr. 2011;53(5):528–31.

    PubMed  Google Scholar 

  47. Sollid LM, Khosla C. Novel therapies for coeliac disease. J Intern Med. 2011;269:604–13.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, İnönü University, 44280, Malatya, Turkey

    Mukadder Ayşe Selimoğlu M.D.

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  1. Mukadder Ayşe Selimoğlu M.D.
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Correspondence to Mukadder Ayşe Selimoğlu M.D. .

Editor information

Editors and Affiliations

  1. Arizona Health Science Center, Mel and Enid Zuckerman, University of Arizona, 1295 N. Martin, Tucson, 85724-5155, Arizona, USA

    Ronald Ross Watson

  2. Centre for Gastroenterology, and Nutrition, University College London, Gower Street, London, WC1E 6BT, United Kingdom

    George Grimble

  3. School of Medicine, Diabetes & Nutritional, King's College London, 150 Stamford St., London, SE1 9NH, United Kingdom

    Victor R. Preedy

  4. Division of Health Promotion Sciences, Mel and Enid Zuckerman, University of Arizona, 1295 N. Martin Avenue, Tucson, 85724, Arizona, USA

    Sherma Zibadi

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Selimoğlu, M.A. (2013). Celiac Disease in Infants: Prevention and Dietary Treatment. In: Watson, R., Grimble, G., Preedy, V., Zibadi, S. (eds) Nutrition in Infancy. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-254-4_11

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  • DOI: https://doi.org/10.1007/978-1-62703-254-4_11

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  • Publisher Name: Humana Press, Totowa, NJ

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  • Online ISBN: 978-1-62703-254-4

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