Stimulation and Inhibition of Neurons

Activation, inhibition, or destruction of the nervous system or its component parts as a vital tool for the investigation of function has undergone remarkable development; indeed, new approaches have been developed that allow for these actions to be used as therapeutic tools.  In Stimulation and Inhibition of Neurons, experts in the field provide an overview of modern methods for generating lesions as well as for stimulating and inhibiting neural pathways.  Many new techniques such as optogenetics and the use of the in situ perfused preparation are examined, while, in other sections, the use and validity of more well-known approaches are reassessed. Written for the Neuromethods series, chapters examine their respective topics thoroughly and include the kind of detail and implementation advice that ensures successful results in the laboratory.

• Clinical applications
• Inhibiting neurons
• Intracellular signalling
• Lesion generation
• Neural pathways
• Neurophysiology
• Optogenetics
• Single neurons
• Stimulating neurons

From the book reviews:

“This is a neurophysiology laboratory manual with step by step instructions on how to record from preparations in vivo and in situ using the rat. … This is a timely and excellent contribution to neurophysiology methods of great interest for students, postdocs, experienced investigators, physiologists, and neuropharmacologists.” (Joseph J. Grenier, Amazon.com, March, 2015)

• , Australian School of Advanced Medicine, Macquarie University, North Ryde, Australia

  Paul M. Pilowsky, Melissa M.J. Farnham, Angelina Y. Fong

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