Abstract
Diabetes affects millions of people worldwide and the incidence is growing day by day. Hyperglycemia, the main culprit in this disease can be managed through the use of intensive insulin therapy and/or oral hypoglycemic agents. However, the ailment is not cured and leaves the patients dependent on treatment for the rest of their lives. Therefore, maintaining an ideal euglycemic state without external intervention is the much-awaited cure for diabetes. It can be achieved through the replacement of lost β cells with new functional β cells or by inducing beta cell regeneration. This chapter reviews the literature regarding various approaches being used today or those expected to be used for this in future.
Keywords
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- Arx:
-
Aristaless-related homeobox
- BCG:
-
Bacillus Calmette-Guérin
- BMP:
-
Bone Morphogenetic Protein
- CCK:
-
Cholecystokinin
- CFA:
-
Complete Freund’s Adjuvant
- CK:
-
Cytokeratin
- DPP:
-
Dipeptidyl Peptidase
- DPSCs:
-
Dental Pulp Stem Cells
- EGF:
-
Epidermal Growth Factor
- EGFP:
-
Enhanced Green Fluorescent Protein
- ES cells :
-
Embryonic Stem cells
- FGF:
-
Fibroblast Growth Factor
- GABA:
-
γ-Aminobutyric acid
- GFP:
-
Green Fluorescent Protein
- GH:
-
Growth Hormone
- GIP:
-
Glucose-Dependent Insulinotropic Polypeptide
- GLP-1:
-
Glucagon-Like Peptide-1
- GSCs:
-
Germline Stem Cells
- GTC-1 cells:
-
high GIP-expressing subpopulation of STC-1 cells
- HbA1c:
-
hemoglobin A1c
- HDAD:
-
Helper-Dependent Adenovirus
- hES cells:
-
human Embryonic Stem cells
- HGF:
-
Hepatocyte Growth Factor
- hiPS cells:
-
Human induced Pluripotent Stem cells
- HSCT:
-
Hematopoeitic Stem Cell Transplantation
- HSLs:
-
Hepatic Stem-Like cells
- ICA:
-
Islet-like Cell Aggregate
- ICM:
-
Inner Cell Mass
- IEC-6 cells:
-
Normal rat small intestine-derived immature intestinal stem cells
- IPF1:
-
Insulin Promoter Factor 1
- iPS cells:
-
Induced Pluripotent Stem cells
- LIF:
-
Leukemia Inhibitory Factor
- MafA:
-
V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
- mTert:
-
Mouse Telomerase reverse transcriptase
- NAD:
-
Nicotinamide Adenine Dinucleotide
- NeuroD:
-
Neurogenic Differentiation
- Ngn3:
-
Neurogenin3
- NOD:
-
Non-Obese Diabetic
- PAK:
-
Pancreas After Kidney
- Pax4:
-
Paired box 4
- Pdx1:
-
Pancreatic and duodenal homeobox 1
- PL:
-
Placental Lactogen
- PMPs:
-
Pancreatic Multipotent Progenitors
- PRL:
-
Prolactin
- PTA:
-
Pancreas Transplant Alone
- RA:
-
Retinoic Acid
- SCID:
-
Severe Combined Immuno Deficiency
- SHCs:
-
Small Hepatocytes
- SPK:
-
Simultaneous Pancreas-Kidney
- SSCs:
-
Spermatogonial Stem Cells
- STC-1 cells:
-
mouse neuroendocrine tumor-derived cells
- TGF:
-
Transforming Growth Factor
- TNF:
-
Tumor Necrosis Factor
- UCB:
-
Umbilical Cord Blood
- YFP:
-
Yellow Fluorescent Protein
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Acknowledgments
The author is supported by the Max-Planck Society, the Dr. H. Storz and Alte Leipziger foundation, the Juvenile Diabetes Research Foundation, the Bundesministerium für Bildung und Forschung (BMBF: 01KU0906), and the NIH Beta Cell Biology Consortium (DK 072495).
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Ahmad, Z. (2013). Pancreatic Regeneration in the Face of Diabetes . In: Baharvand, H., Aghdami, N. (eds) Regenerative Medicine and Cell Therapy. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-098-4_9
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