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Ghrelin in Health and Disease pp 91–110Cite as

Ghrelin Regulation of AMPK in the Hypothalamus and Peripheral Tissues

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Part of the book series: Contemporary Endocrinology ((COE,volume 10))

Abstract

Adenosine 5′ monophosphate-activated protein kinase (AMPK) is a regulator of cellular and systemic energy homeostasis. Several appetite-regulating and metabolic hormones are known to influence AMPK. Ghrelin displays central orexigenic as well as direct peripheral metabolic effects and both could be related to its effects on AMPK activity. In the hypothalamus ghrelin stimulates AMPK and this has been associated with its orexigenic effects. Evidence suggests a tight interaction between the central ghrelin and cannabinoid systems, and hypothalamic AMPK appears to be a common mediator of their orexigenic effects. In the liver and adipose tissue, ghrelin inhibits AMPK and this could be the underlying mechanism for its diabetogenic and lipogenic effects. While in cardiac muscle, ghrelin stimulates AMPK which could be linked to its positive inotropic effects. In summary, tissue-specific alterations of AMPK activity play an important role in the diverse effects of ghrelin.

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Acknowledgements

We are very grateful for the Rod Flower Summer Vacation Scholarship (MS), the sponsorship by Goldberg-Schachmann & Freda Becker Trusts (MS) and the Wellcome Trust Research Grant (BK, MK).

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  1. Centre for Endocrinology, William Harvey Research Institute, Barts and The London, Queen Mary’s School of Medicine and Dentisty, Charterhouse Square, London, EC1M 6BQ, UK

    Miski Scerif M.B.B.S., B.Med.Sci., Blerina Kola M.D., Ph.D. & Márta Korbonits M.D., Ph.D.

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  1. Miski Scerif M.B.B.S., B.Med.Sci.
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  2. Blerina Kola M.D., Ph.D.
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  3. Márta Korbonits M.D., Ph.D.
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Correspondence to Márta Korbonits M.D., Ph.D. .

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  1. , Department of Metabolism and Aging, The Scripps Research Institute Florida, Scripps Way 3B3 130, Jupiter, 33458, Florida, USA

    Roy G. Smith

  2. , Department of Medicine, University of Virginia, Ray C Hunt Drive 450, Charlottesville, 22908, Virginia, USA

    Michael O. Thorner

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Scerif, M., Kola, B., Korbonits, M. (2012). Ghrelin Regulation of AMPK in the Hypothalamus and Peripheral Tissues. In: Smith, R., Thorner, M. (eds) Ghrelin in Health and Disease. Contemporary Endocrinology, vol 10. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-903-7_5

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