Overview
- Includes epigenetic alterations that can be used in clinical practice
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
- Includes supplementary material: sn.pub/extras
Part of the book series: Methods in Molecular Biology (MIMB, volume 863)
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Table of contents (29 protocols)
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Front Matter
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Early Epigenetic Events in Cancer
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Front Matter
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Cancer Specific Type Epigenetic Changes
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Front Matter
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Methods and Technologies used for Epigenetic Changes’ Detection
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Front Matter
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Keywords
About this book
The epigenetic regulation plays an important role in normal development and maintenance of tissue specific genes expression in humans and the disturbance of these patterns lead to changes involved in tumor formation. More recently, epigenetic changes have been observed in early stages of tumor development and together with the genetic alterations have been defined as abnormalities, necessary for cancer initiation and progression. In, Cancer Epigenetics: Methods and Protocols, expert researchers reviewed these epigenetics changes in different tumor types and described several technologies that are currently available to detect epigenetic changes. These technologies have lead to a better understanding of the processes in normal and cancerous cells. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.
Thorough and intuitive, Cancer Epigenetics: Methods and Protocols aids scientists in continuing to study epigenetic alterations used in clinical practice as biomarkers of early cancerous lesions or markers of progression and prognosis.
Reviews
From the reviews:
“This book provides a clear description of the epigenetic changes in cancer that are important in early detection, progression, and prognosis, as well as the design of therapeutic tools necessary to combat cancer. … This is an excellent resource for scientists and oncologists interested in learning about currently available technologies to detect epigenetic changes that serve as biomarkers in detection of early cancerous lesions as well as markers of cancer progression and prognosis.” (Omer Iqbal, Doody’s Book Reviews, August, 2012)Editors and Affiliations
Bibliographic Information
Book Title: Cancer Epigenetics
Book Subtitle: Methods and Protocols
Editors: Ramona G. Dumitrescu, Mukesh Verma
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-61779-612-8
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media, LLC 2012
Hardcover ISBN: 978-1-61779-611-1Published: 24 February 2012
Softcover ISBN: 978-1-4939-6204-4Published: 23 August 2016
eBook ISBN: 978-1-61779-612-8Published: 23 February 2012
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XIII, 492
Number of Illustrations: 10 b/w illustrations, 32 illustrations in colour
Topics: Cancer Research