Abstract
Recent preclinical work investigating the role of progenitor cell therapies for central nervous system injuries has shown potential neuroprotection in the setting of traumatic brain injury, spinal cord injury, and ischemic stroke. Although the exact mechanism of action remains controversial, the growing amount of preclinical data demonstrating the potential benefit associated with progenitor cell therapy for neurological injury warrants the development of well-controlled clinical trials to investigate therapeutic safety and efficacy. In this chapter, we review the currently active or recently completed clinical trials investigating the safety and potential efficacy of bone marrow-derived progenitor cell therapies for the treatment of traumatic brain injury, spinal cord injury, and ischemic stroke. Our review of the literature shows that although the preliminary clinical trials reviewed in this chapter offer novel data supporting the potential efficacy of stem/progenitor cell therapies for central nervous system injury, a great deal of additional work is needed to ensure the safety, efficacy, and mechanisms of progenitor cell therapy prior to widespread clinical trials.
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Abbreviations
- ASIA:
-
American Spinal Injury Association
- BMMC:
-
Bone marrow mononuclear cell
- CNS:
-
Central nervous system
- FDA:
-
US Food and Drug Administration
- GCS:
-
Glasgow Coma Scale
- GM-CSF:
-
Granulocyte monocyte colony-stimulating factor
- LP:
-
Lumbar puncture
- MCA:
-
Middle cerebral artery
- MRI:
-
Magnetic resonance imaging
- NIHSS:
-
National Institutes of Health Stroke Scale
- SCI:
-
Spinal cord injury
- SSEP:
-
Serial somatosensory evoked potential
- TBI:
-
Traumatic brain injury
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Walker, P.A., Shah, S.K., Baumgartner, J.E. (2011). Progenitor Cell Therapy for the Treatment of Central Nervous System Injury: A Review of the State of Current Clinical Trials. In: Charles, S. (eds) Progenitor Cell Therapy for Neurological Injury. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-965-9_9
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DOI: https://doi.org/10.1007/978-1-60761-965-9_9
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