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Stem Cell Transplantation to the Heart

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Stem Cells & Regenerative Medicine

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Cardiovascular disease remains the most potent killer in all developed societies. Heart failure is the most common cause of hospitalization in the United States. Despite impressive improvements in the interventional and medical therapy of ischemic coronary artery disease, this disorder remains the most common cause of heart failure. Given the severe limitation on the availability of and the long-term morbidity associated with cardiac transplantation, a means of preventing or reversing the loss of functional myocardium in end-stage heart disease is an important translational target. This chapter discusses the progress of cardiac transplantation and the development of possible clinical targets, as well as clinical trials in humans.

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  1. Division of Cardiothoracic Surgery, Director, Cardiothoracic Translational Research Laboratory, University of California at San Francisco, San Francisco, CA, USA

    Michael J. Mann

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  1. Gene Expression Systems, Inc., Waltham, Massachusetts, USA

    Krishnarao Appasani

  2. Student Science, Wyllys Ave 45, Middletown, 06459, Connecticut, USA

    Raghu K. Appasani

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Mann, M.J. (2011). Stem Cell Transplantation to the Heart. In: Appasani, K., Appasani, R. (eds) Stem Cells & Regenerative Medicine. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-860-7_17

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