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Amyloidosis pp 1–14Cite as

Fibril Structure and Fibrillogenesis

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Part of the book series: Contemporary Hematology ((CH))

Abstract

Amyloid fibrils are protein aggregates with a characteristic cross-β structure found in association with many human diseases. This chapter begins with a review of some basics of protein biochemistry and the theory of amyloid formation. The rest of the chapter focuses on the biophysical understanding of amyloid formation, touching on the kinetics and thermodynamics of fibril formation, different tools that can be used to probe fibril formation, and current theories on the mechanism of fibril formation. Finally, we discuss current structural approaches for the study of amyloid fibrils and several structural models that have been proposed as a result of these studies.

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Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA

    Douglas J. Martin BS, Edward G. Randles PhD & Marina Ramirez-Alvarado PhD

  2. Laboratory for Neurophysics and Intelligence Modeling, Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA

    Edward G. Randles PhD

Authors
  1. Douglas J. Martin BS
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  2. Edward G. Randles PhD
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  3. Marina Ramirez-Alvarado PhD
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Editor information

Editors and Affiliations

  1. Mayo Clinic, First Street SW. 200, Rochester, 55905, Minnesota, USA

    Morie A. Gertz

  2. Mayo Clinic, First Street SW. 200, Rochester, 55905, Minnesota, USA

    S. Vincent Rajkumar

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Martin, D.J., Randles, E.G., Ramirez-Alvarado, M. (2010). Fibril Structure and Fibrillogenesis. In: Gertz, M., Rajkumar, S. (eds) Amyloidosis. Contemporary Hematology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-631-3_1

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  • DOI: https://doi.org/10.1007/978-1-60761-631-3_1

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-630-6

  • Online ISBN: 978-1-60761-631-3

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