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Membrane Receptors, Channels and Transporters in Pulmonary Circulation pp 109–122Cite as

Physiological Functions of Transient Receptor Potential Channels in Pulmonary Arterial Smooth Muscle Cells

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Part of the book series: Advances in Experimental Medicine and Biology ((volume 661))

Abstract

The transient receptor potential (TRP) gene superfamily, which consists of 7 subfamilies with at least 28 mammalian homologues, is known to encode a wide variety of cation channels with diverse biophysical properties, activation mechanisms, and physiological functions. Recent studies have identified multiple TRP channel subtypes, belonging to the canonical (TRPC), melastatin-related (TRPM), and vanilloid-related (TRPV) subfamilies, in pulmonary arterial smooth muscle cells (PASMCs). They operate as specific Ca2+ pathways responsive to stimuli, including Ca2+ store depletion, receptor activation, reactive oxygen species, growth factors, and mechanical stress. Increasing evidence suggests that these channels play crucial roles in agonist-induced pulmonary vasoconstriction, hypoxic pulmonary vasoconstriction, smooth muscle cell proliferation, vascular remodeling, and pulmonary arterial hypertension. This chapter highlighted and discussed these putative physiological functions of TRP channels in pulmonary vasculatures. Since Ca2+ ions regulate many cellular processes via specific Ca2+ signals, future investigations of these novel channels will likely uncover more important regulatory mechanisms of pulmonary vascular functions in health and in disease states.

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Author information

Authors and Affiliations

  1. Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, 21224, USA

    Xiao-Ru Yang & James S. K. Sham

  2. Department of Physiology and Pathophysiology, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China

    Mo-Jun Lin

Authors
  1. Xiao-Ru Yang
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  2. Mo-Jun Lin
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  3. James S. K. Sham
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Corresponding author

Correspondence to James S. K. Sham .

Editor information

Editors and Affiliations

  1. Departments of Medicine and Pharmacology, University of Illinois at Chicago, Chicago, 60612, USA

    Jason X. -J. Yuan

  2. Guy’s Hospital Campus, Dept. Physiology, King’s College London, London, SE1 1UL, United Kingdom

    Jeremy P. T. Ward

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© 2010 Humana Press, a part of Springer Science+Business Media, LLC

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Yang, XR., Lin, MJ., Sham, J.S.K. (2010). Physiological Functions of Transient Receptor Potential Channels in Pulmonary Arterial Smooth Muscle Cells. In: Yuan, JJ., Ward, J. (eds) Membrane Receptors, Channels and Transporters in Pulmonary Circulation. Advances in Experimental Medicine and Biology, vol 661. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-500-2_7

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