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Lymphoblastic Leukemia and Lymphoma

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Part of the book series: Contemporary Hematology ((CH))

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This chapter covers T and B lymphoblastic neoplasms, including acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL). Morphologic, immunophenotypic, and cytogenetic features are discussed along with the parameters of various modalities used in their diagnosis. The techniques and utility of minimum residual disease (MRD) measurement after therapy is discussed, as are new insights into the molecular biology of leukemogenesis gleaned from recent studies using gene expression profiling and copy number analysis via microarray techniques.

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References

  1. Borowitz MJ, Chan JKC. B lymphoblastic leukaemia/lymphoma, NOS, B lymphoblastic leukaemia/lymphoma with recurrent genetic abnormalities, and T lymphoblastic leukaemia/lymphoma. In: Swerdlow SH, Campo E, Harris NL, et al., eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon, France: International Agency for Research on Cancer, 2008:168-78.

    Google Scholar 

  2. Yeoh EJ, Ross ME, Shurtleff SA, et al. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 2002;1:133-43.

    Article  PubMed  CAS  Google Scholar 

  3. Mullighan CG, Su X, Zhang J, et al. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 2009;360:470-80.

    Article  PubMed  CAS  Google Scholar 

  4. Weng AP, Ferrando AA, Lee W, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004;306:269-71.

    Article  PubMed  CAS  Google Scholar 

  5. Ferrando AA, Neuberg DS, Staunton J, et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 2002;1:75-87.

    Article  PubMed  CAS  Google Scholar 

  6. Schultz KR, Pullen DJ, Sather HN, et al. Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children’s Cancer Group (CCG). Blood 2007;109:926-35.

    Article  PubMed  CAS  Google Scholar 

  7. Harrison CJ, Foront L. Cytogenetics and molecular genetics of acute lymphoblastic leukemia. Rev Clin Exp Hematol 2002;6:91-113.

    Article  PubMed  CAS  Google Scholar 

  8. Graux C, Cools J, Michaux L, et al. Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast. Leukemia 2006;20:1496-510.

    Article  PubMed  CAS  Google Scholar 

  9. Vega F, Medeiros LJ, Davuluri R, et al. t(8;13) positive bilineal lymphomas: report of 6 cases. Am J Surg Path 2008;32:14-20.

    Article  PubMed  Google Scholar 

  10. Yang JJ, Cheng C, Yang W. Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. JAMA 2009;301:393-403.

    Article  PubMed  CAS  Google Scholar 

  11. Rocha JC, Cheng C, Liu W. Pharmacogenetics of outcome in children with acute lymphoblastic leukemia. Blood 2005;105:4752-8.

    Article  PubMed  CAS  Google Scholar 

  12. Szczepanski T. Why and how to quantify minimum residual disease in acute lymphoblastic leukemia? Leukemia 2007;21:622-6.

    PubMed  CAS  Google Scholar 

  13. Campana D. Determination of minimum residual disease in leukaemia patients. Br J Haematol 2003;121:823-38.

    Article  PubMed  Google Scholar 

  14. Campana D, Coustan-Smith E. Detection of minimal residual disease in acute leukemia by flow cytometry. Cytometry (Communications in Clinical Cytometry) 1999;38:139-52.

    Article  Google Scholar 

  15. Chen W, Karandikar NJ, McKenna RW, Kroft SH. Stability of leukemia-associated immunophenotypes in precursor B-lymphoblastic leukemia/lymphoma: a single institution experience. Am J Clin Path 2007;127:39-46.

    Article  PubMed  Google Scholar 

  16. Neale GAM, Coustan-Smith E, Stow P, et al. Comparative analysis of flow cytometry and polymerase chain reaction for the detection of minimal residual disease in childhood acute lymphoblastic leukemia. Leukemia 2004;18:934-8.

    Article  PubMed  CAS  Google Scholar 

  17. Kohlmann A, Shoch C, Shnittger S, et al. Pediatric acute lymphoblastic leukemia (ALL) gene expression signatures classify an idependent cohort of adult ALL patients. Leukemia 2004;18:63-71.

    Article  PubMed  CAS  Google Scholar 

  18. Chiaretti S, Li X, Gentleman R, et al. Gene expression profiles of B-lineage adult acute lymphoblastic leukemia reveal genetic patterns that identify lineage derivation and distinct mechanisms of transformation. Clin Cancer Res 2005;11:7209-19.

    Article  PubMed  CAS  Google Scholar 

  19. Aifantis I, Raetz E, Buonamici S. Molecular pathogenesis of T-cell leukaemia and lymphoma. Nat Rev Immunol 2008;8:380-90.

    Article  PubMed  CAS  Google Scholar 

  20. Lin P, Jones D, Dorfman DM, Medeiros LJ. Precursor B-cell lymphoblastic lymphoma: a predominantly extranodal tumor with low propensity for leukemic involvement. Am J Surg Pathol 2000;24:1480-90.

    Google Scholar 

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Correspondence to Andrea M. Sheehan .

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© 2010 Humana Press, a part of Springer Science+Business Media, LLC

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Sheehan, A.M. (2010). Lymphoblastic Leukemia and Lymphoma. In: Jones, D. (eds) Neoplastic Hematopathology. Contemporary Hematology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-384-8_13

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  • DOI: https://doi.org/10.1007/978-1-60761-384-8_13

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-383-1

  • Online ISBN: 978-1-60761-384-8

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