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Pancreatic Stem Cells pp 99–109Cite as

Remaining Challenges and Clinical Perspectives

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Unlike other potential targets of future stem cell approaches, there is already a current cell therapy for the treatment of type I diabetes. Indeed, islet transplantation has proven successful in inducing insulin independence for at least 1 year after the procedure. Progress in this discipline during the past 20 years has paved the way for stem cell-based therapies. Here we review the current state of the art of islet transplantation and examine the challenges that need to be addressed before a transition is made to stem cell-derived insulin-producing cells, with particular emphasis on the immunological aspects (rejection and autoimmunity) of type I diabetes.

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Authors and Affiliations

  1. Development & Stem Cell Laboratory, Diabetes Research Institute University of Miami, Miami, FL, 33136, USA

    Juan Domínguez-Bendala MSc, PhD (Research Assistant Professor of Surgery Pancreatic)

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  1. Juan Domínguez-Bendala MSc, PhD
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Correspondence to Juan Domínguez-Bendala MSc, PhD .

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC

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Domínguez-Bendala, J. (2009). Remaining Challenges and Clinical Perspectives. In: Pancreatic Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-60761-132-5_8

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