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A Practical Guide to Recurrent Stroke Prevention

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Part of the book series: Clinical Hypertension and Vascular Diseases ((CHVD))

Abstract

The risk of recurrent stroke following a first event is high. Within the first year, up to 14% of patients presenting with ischemic stroke will go on to have another stroke (1), and up to 40% in the following 5 years (2). Risk is highest in the first month after stroke (1). Recurrent stroke is associated with poorer outcome, with higher mortality and functional disability, than first stroke. Recurrent stroke risk is modulated by subtype and associated risk factors, which can guide both targeted and general recurrent prevention strategies. This chapter provides an overview of stroke subtypes and risk factors, and outlines an approach to secondary prevention based on best medical evidence and current published guidelines.

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References

  1. Sacco RL, Foulkes MA, Mohr JP, Wolf PA, Hier DB, Price TR. Determinants of early recurrence of cerebral infarction. The stroke data bank. Stroke. Aug 1989;20(8):983–9.

    CAS  PubMed  Google Scholar 

  2. Sacco RL, Shi T, Zamanillo MC, Kargman DE. Predictors of mortality and recurrence after hospitalized cerebral infarction in an urban community: the Northern Manhattan stroke study. Neurology. Apr 1994;44(4):626–34.

    CAS  PubMed  Google Scholar 

  3. Sacco RL, Boden-Albala B, Abel G, et al. Race-ethnic disparities in the impact of stroke risk factors: the Northern Manhattan stroke study. Stroke. Aug 2001;32(8):1725–31.

    CAS  PubMed  Google Scholar 

  4. Petty GW, Brown RD Jr., Whisnant JP, Sicks JD, O’Fallon WM, Wiebers DO. Ischemic stroke subtypes: a population-based study of functional outcome, survival, and recurrence. Stroke. May 2000;31(5):1062–8.

    CAS  PubMed  Google Scholar 

  5. Woo D, Sauerbeck LR, Kissela BM, et al. Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study. Stroke. May 2002;33(5):1190–5.

    Article  PubMed  Google Scholar 

  6. Brott T, Thalinger K, Hertzberg V. Hypertension as a risk factor for spontaneous intracerebral hemorrhage. Stroke. Nov–Dec 1986;17(6):1078–83.

    CAS  PubMed  Google Scholar 

  7. Greenberg SM. Cerebral amyloid angiopathy and vessel dysfunction. Cerebrovasc Dis. 2002;13(Suppl 2):42–7.

    Article  CAS  PubMed  Google Scholar 

  8. Albers GW, Caplan LR, Easton JD, et al. Transient ischemic attack – proposal for a new definition. N Engl J Med. 21 Nov 2002;347(21):171316.

    Article  Google Scholar 

  9. Easton JD, Saver JL, Albers GW, et al. Definition and Evaluation of Transient Ischemic Attack. A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease. Stroke. Jun 2009;40(6): 2276–93.

    Article  PubMed  Google Scholar 

  10. Lovett JK, Coull AJ, Rothwell PM. Early risk of recurrence by subtype of ischemic stroke in population-based incidence studies. Neurology. 24 Feb 2004;62(4):569–73.

    CAS  PubMed  Google Scholar 

  11. Johnston SC, Rothwell PM, Nguyen-Huynh MN, et al. Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet. 27 Jan 2007;369(9558):283–92.

    Article  PubMed  Google Scholar 

  12. Cerebral Embolism Task Force. Cardiogenic brain embolism. Arch Neurol. Jan 1986;43(1):71–84.

    Google Scholar 

  13. Second Report of the Cerebral Embolism Task Force. Cardiogenic brain embolism. Arch Neurol. Jul 1989;46(7):727–43.

    Google Scholar 

  14. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation: a major contributor to stroke in the elderly. The framingham study. Arch Intern Med. Sep 1987;147(9):1561–4.

    Article  CAS  PubMed  Google Scholar 

  15. Hart RG, Pearce LA, Miller VT, et al. Cardioembolic vs. noncardioembolic strokes in atrial fibrillation: frequency and effect of antithrombotic agents in the stroke prevention in atrial fibrillation studies. Cerebrovasc Dis. Jan–Feb 2000;10(1):39–43.

    Article  CAS  PubMed  Google Scholar 

  16. Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation. Analysis of pooled data from five randomized controlled trials. Arch Intern Med. 11 Jul 1994;154(13):1449–57.

    Article  Google Scholar 

  17. Gage BF, Waterman AD, Shannon W, Boechler M, Rich MW, Radford MJ. Validation of clinical classification schemes for predicting stroke: results from the national registry of atrial fibrillation. JAMA. 13 Jun 2001;285(22):2864–70.

    Article  CAS  PubMed  Google Scholar 

  18. Albers GW, Amarenco P, Easton JD, Sacco RL, Teal P. Antithrombotic and thrombolytic therapy for ischemic stroke: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. Jun 2008;133(6 Suppl):630S–69S.

    Article  CAS  PubMed  Google Scholar 

  19. Singer DE, Albers GW, Dalen JE, et al. Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. Jun 2008;133(6 Suppl):546S–92S.

    Article  CAS  PubMed  Google Scholar 

  20. Stroke Prevention in Atrial Fibrillation III randomised clinical trial. Adjusted-dose warfarin versus low-intensity, fixed-dose warfarin plus aspirin for high-risk patients with atrial fibrillation. Lancet. 7 Sep 1996;348(9028):633–8.

    Article  Google Scholar 

  21. Hylek EM, Skates SJ, Sheehan MA, Singer DE. An analysis of the lowest effective intensity of prophylactic anticoagulation for patients with nonrheumatic atrial fibrillation. N Engl J Med. 22 Aug 1996;335(8):540–6.

    Article  CAS  PubMed  Google Scholar 

  22. Perret-Guillaume C, Wahl DG. Low-dose warfarin in atrial fibrillation leads to more thromboembolic events without reducing major bleeding when compared to adjusted-dose–a meta-analysis. Thromb Haemost. Feb 2004;91(2):394–402.

    CAS  PubMed  Google Scholar 

  23. Sacco RL, Adams R, Albers G, et al. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline. Stroke. Feb 2006;37(2):577–617.

    Article  PubMed  Google Scholar 

  24. Connolly S, Pogue J, Hart R, et al. Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial. Lancet. 10 Jun 2006;367(9526):1903–12.

    Article  CAS  PubMed  Google Scholar 

  25. ACTIVE Investigators, Connolly SJ, Pogue J, Hart RG, Hohnloser SH, Pfeffer M, Chrolavicius S, Yusuf S. Effect of clopidogrel added to aspirin in patients with atrial fibrillation. N Engl J Med. May 2009;360(20):2066–78.

    Google Scholar 

  26. Salem DN, O’Gara PT, Madias C, Pauker SG. Valvular and structural heart disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. Jun 2008;133(6 Suppl):593S–629S.

    Article  PubMed  Google Scholar 

  27. Braunwald E, Antman EM, Beasley JW, et al. ACC/AHA 2002 guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction – summary article: a report of the American College of Cardiology/American Heart Association task force on practice guidelines (Committee on the Management of Patients With Unstable Angina). J Am Coll Cardiol. 2 Oct 2002;40(7):1366–74.

    Article  PubMed  Google Scholar 

  28. Dries DL, Rosenberg YD, Waclawiw MA, Domanski MJ. Ejection fraction and risk of thromboembolic events in patients with systolic dysfunction and sinus rhythm: evidence for gender differences in the studies of left ventricular dysfunction trials. J Am Coll Cardiol. Apr 1997;29(5):1074–80.

    Article  CAS  PubMed  Google Scholar 

  29. Pullicino P, Thompson JL, Barton B, Levin B, Graham S, Freudenberger RS. Warfarin versus aspirin in patients with reduced cardiac ejection fraction (WARCEF): rationale, objectives, and design. J Card Fail. Feb 2006;12(1):39–46.

    Article  CAS  PubMed  Google Scholar 

  30. Wechsler LR. PFO and stroke: what are the data? Cardiol Rev. Jan–Feb 2008;16(1):53–7.

    Article  PubMed  Google Scholar 

  31. Thaler DE, Saver JL. Cryptogenic stroke and patent foramen ovale. Curr Opin Cardiol. Nov 2008;23(6):537–44.

    Article  PubMed  Google Scholar 

  32. Hagen PT, Scholz DG, Edwards WD. Incidence and size of patent foramen ovale during the first 10 decades of life: an autopsy study of 965 normal hearts. Mayo Clin Proc. Jan 1984;59(1):17–20.

    CAS  PubMed  Google Scholar 

  33. Lechat P, Mas JL, Lascault G, et al. Prevalence of patent foramen ovale in patients with stroke. N Engl J Med. 5 May 1988;318(18):1148–52.

    Article  CAS  PubMed  Google Scholar 

  34. Homma S, Di Tullio MR, Sacco RL, Mihalatos D, Li Mandri G, Mohr JP. Characteristics of patent foramen ovale associated with cryptogenic stroke. A biplane transesophageal echocardiographic study. Stroke. Mar 1994;25(3):582–6.

    CAS  PubMed  Google Scholar 

  35. Mas JL, Arquizan C, Lamy C, et al. Recurrent cerebrovascular events associated with patent foramen ovale, atrial septal aneurysm, or both. N Engl J Med. 13 Dec 2001;345(24):1740–6.

    Article  CAS  PubMed  Google Scholar 

  36. Stollberger C, Slany J, Schuster I, Leitner H, Winkler WB, Karnik R. The prevalence of deep venous thrombosis in patients with suspected paradoxical embolism. Ann Intern Med. 15 Sep 1993;119(6):461–5.

    CAS  PubMed  Google Scholar 

  37. Messe SR, Silverman IE, Kizer JR, et al. Practice parameter: recurrent stroke with patent foramen ovale and atrial septal aneurysm: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 13 Apr 2004;62(7):1042–50.

    CAS  PubMed  Google Scholar 

  38. Rundek T. Beyond percent stenosis: carotid plaque surface irregularity and risk of stroke. Int J Stroke. Aug 2007;2(3):169–71.

    Article  PubMed  Google Scholar 

  39. Polak JF, Shemanski L, O’Leary DH, et al. Hypoechoic plaque at US of the carotid artery: an independent risk factor for incident stroke in adults aged 65 years or older. Cardiovascular Health Study. Radiology. Sep 1998;208(3):649–54.

    CAS  PubMed  Google Scholar 

  40. Fisher M, Paganini-Hill A, Martin A, et al. Carotid plaque pathology: thrombosis, ulceration, and stroke pathogenesis. Stroke. Feb 2005;36(2):253–7.

    Article  PubMed  Google Scholar 

  41. Eliasziw M, Streifler JY, Fox AJ, Hachinski VC, Ferguson GG, Barnett HJ. Significance of plaque ulceration in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial. Stroke. Feb 1994;25(2):304–8.

    CAS  PubMed  Google Scholar 

  42. North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med. 15 Aug 1991;325(7):445–53.

    Article  Google Scholar 

  43. European Carotid Surgery Trialists’ Collaborative Group. MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70–99%) or with mild (0–29%) carotid stenosis. Lancet. 25 May 1991;337(8752):1235–43.

    Article  Google Scholar 

  44. Mayberg MR, Wilson SE, Yatsu F, et al. Carotid endarterectomy and prevention of cerebral ischemia in symptomatic carotid stenosis. Veterans Affairs Cooperative Studies Program 309 Trialist Group. JAMA. 18 Dec 1991;266(23):3289–94.

    Article  CAS  PubMed  Google Scholar 

  45. Rothwell PM, Eliasziw M, Gutnikov SA, Warlow CP, Barnett HJ. Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery. Lancet. 20 Mar 2004;363(9413):915–24.

    Article  CAS  PubMed  Google Scholar 

  46. Barnett HJ, Taylor DW, Eliasziw M, et al. Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med. 12 Nov 1998;339(20):1415–25.

    Article  CAS  PubMed  Google Scholar 

  47. Streifler JY, Eliasziw M, Benavente OR, et al. The risk of stroke in patients with first-ever retinal vs hemispheric transient ischemic attacks and high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial. Arch Neurol. Mar 1995;52(3):246–9.

    CAS  PubMed  Google Scholar 

  48. Kappelle LJ, Eliasziw M, Fox AJ, Sharpe BL, Barnett HJ. Importance of intracranial atherosclerotic disease in patients with symptomatic stenosis of the internal carotid artery. The North American Symptomatic Carotid Endarterectomy Trail. Stroke. Feb 1999;30(2):282–6.

    CAS  PubMed  Google Scholar 

  49. Ederle J, Bonati LH, Dobson J, Featherstone RL, Gaines PA, Beard JD, Venables GS, Markus HS, Clifton A, Sandercock P, Brown MM, CAVATAS Investigators. Endovascular versus surgical treatment in patients with carotid stenosis in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS) a randomised trial. Lancet Neurol. Oct 2009;8(10):898–907.

    Google Scholar 

  50. Yadav JS, Wholey MH, Kuntz RE, et al. Protected carotid-artery stenting versus endarterectomy in high-risk patients. N Engl J Med. 7 Oct 2004;351(15):1493–501.

    Article  CAS  PubMed  Google Scholar 

  51. Hobson RW 2nd.. Update on the Carotid Revascularization Endarterectomy versus Stent Trial (CREST) protocol. J Am Coll Surg. Jan 2002;194(1 Suppl):S9–S14.

    Article  PubMed  Google Scholar 

  52. Mansour MA. Carotid artery stenting in the SPACE and EVA-3S trials: analysis and update. Perspect Vasc Surg Endovasc Ther. Mar 2008;20(1):1114.

    Article  Google Scholar 

  53. Roubin GS, New G, Iyer SS, et al. Immediate and late clinical outcomes of carotid artery stenting in patients with symptomatic and asymptomatic carotid artery stenosis: a 5-year prospective analysis. Circulation. 30 Jan 2001;103(4):532–7.

    CAS  PubMed  Google Scholar 

  54. The EC/IC Bypass Study Group. Failure of extracranial-intracranial arterial bypass to reduce the risk of ischemic stroke. Results of an international randomized trial. The EC/IC Bypass Study Group. N Engl J Med. 7 Nov 1985;313(19):1191–200.

    Article  Google Scholar 

  55. Adams HP Jr., Powers WJ, Grubb RL Jr., Clarke WR, Woolson RF. Preview of a new trial of extracranial-to-intracranial arterial anastomosis: the carotid occlusion surgery study. Neurosurg Clin N Am. Jul 2001;12(3):613–24. ix–x

    PubMed  Google Scholar 

  56. Grubb RL Jr., Powers WJ, Derdeyn CP, Adams HP Jr., Clarke WR. The Carotid Occlusion Surgery Study. Neurosurg Focus. 15 Mar 2003;14(3):e9.

    Article  PubMed  Google Scholar 

  57. Gorelick PB, Wong KS, Bae HJ, Pandey DK. Large artery intracranial occlusive disease: a large worldwide burden but a relatively neglected frontier. Stroke. Aug 2008;39(8):2396–9.

    Article  PubMed  Google Scholar 

  58. Chimowitz MI, Lynn MJ, Howlett-Smith H, et al. Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis. N Engl J Med. 31 Mar 2005;352(13):1305–16.

    Article  CAS  PubMed  Google Scholar 

  59. Thijs VN, Albers GW. Symptomatic intracranial atherosclerosis: outcome of patients who fail antithrombotic therapy. Neurology. 22 Aug 2000;55(4):490–7.

    CAS  PubMed  Google Scholar 

  60. Bogousslavsky J, Barnett HJ, Fox AJ, Hachinski VC, Taylor W. Atherosclerotic disease of the middle cerebral artery. Stroke. Nov–Dec 1986;176:1112–20.

    CAS  PubMed  Google Scholar 

  61. Chimowitz MI, Kokkinos J, Strong J, et al. The Warfarin-Aspirin Symptomatic Intracranial Disease Study. Neurology. Aug 1995;45(8):1488–93.

    CAS  PubMed  Google Scholar 

  62. SSYLVIA Study Investigators. Stenting of Symptomatic Atherosclerotic Lesions in the Vertebral or Intracranial Arteries (SSYLVIA): study results. Stroke. Jun 2004;35(6):1388–92.

    Google Scholar 

  63. Derdeyn CP, Chimowitz MI. Angioplasty and stenting for atherosclerotic intracranial stenosis: rationale for a randomized clinical trial. Neuroimaging Clin N Am. Aug 2007;17(3):355–63. viii–ix

    Article  PubMed  Google Scholar 

  64. Schievink WI. Spontaneous dissection of the carotid and vertebral arteries. N Engl J Med. 22 Mar 2001;344(12):898–906.

    Article  CAS  PubMed  Google Scholar 

  65. Rubinstein SM, Peerdeman SM, van Tulder MW, Riphagen I, Haldeman S. A systematic review of the risk factors for cervical artery dissection. Stroke. Jul 2005;36(7):1575–80.

    Article  PubMed  Google Scholar 

  66. Bassi P, Lattuada P, Gomitoni A. Cervical cerebral artery dissection: a multicenter prospective study (preliminary report). Neurol Sci. May 2003;24(Suppl 1):S4–S7.

    Article  PubMed  Google Scholar 

  67. Schievink WI, Mokri B, O’Fallon WM. Recurrent spontaneous cervical-artery dissection. N Engl J Med. 10 Feb 1994;330(6):393–7.

    Article  CAS  PubMed  Google Scholar 

  68. Touze E, Gauvrit JY, Meder JF, Mas JL. Prognosis of cervical artery dissection. Front Neurol Neurosci. 2005;20:129–39.

    Article  PubMed  Google Scholar 

  69. Bae H, Jeong D, Doh J, Lee K, Yun I, Byun B. Recurrence of bleeding in patients with hypertensive intracerebral hemorrhage. Cerebrovasc Dis. Mar–Apr 1999;9(2):102–8.

    Article  CAS  PubMed  Google Scholar 

  70. Passero S, Burgalassi L, D’Andrea P, Battistini N. Recurrence of bleeding in patients with primary intracerebral hemorrhage. Stroke. Jul 1995;26(7):1189–92.

    CAS  PubMed  Google Scholar 

  71. Hanger HC, Wilkinson TJ, Fayez-Iskander N, Sainsbury R. The risk of recurrent stroke after intracerebral haemorrhage. J Neurol Neurosurg Psychiatry. Aug 2007;78(8):836–40.

    Article  CAS  PubMed  Google Scholar 

  72. Gonzalez-Duarte A, Cantu C, Ruiz-Sandoval JL, Barinagarrementeria F. Recurrent primary cerebral hemorrhage: frequency, mechanisms, and prognosis. Stroke. Sep 1998;29(9):1802–5.

    CAS  PubMed  Google Scholar 

  73. Ariesen MJ, Claus SP, Rinkel GJ, Algra A. Risk factors for intracerebral hemorrhage in the general population: a systematic review. Stroke. Aug 2003;34(8):2060–5.

    Article  CAS  PubMed  Google Scholar 

  74. O’Donnell HC, Rosand J, Knudsen KA, et al. Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage. N Engl J Med. 27 Jan 2000;3424:240–5.

    Article  PubMed  Google Scholar 

  75. Fan YH, Zhang L, Lam WW, Mok VC, Wong KS. Cerebral microbleeds as a risk factor for subsequent intracerebral hemorrhages among patients with acute ischemic stroke. Stroke. Oct 2003;34(10):2459–62.

    Article  PubMed  Google Scholar 

  76. Arakawa S, Saku Y, Ibayashi S, Nagao T, Fujishima M. Blood pressure control and recurrence of hypertensive brain hemorrhage. Stroke. Sep 1998;299:1806–9.

    CAS  PubMed  Google Scholar 

  77. Eckman MH, Rosand J, Knudsen KA, Singer DE, Greenberg SM. Can patients be anticoagulated after intracerebral hemorrhage? A decision analysis. Stroke. Jul 2003;34(7):1710–16.

    Article  PubMed  Google Scholar 

  78. EAFT (European Atrial Fibrillation Trial) Study Group. Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke. EAFT (European Atrial Fibrillation Trial) Study Group. Lancet. 20 Nov 1993;342(8882):1255–62.

    Google Scholar 

  79. Pessin MS, Estol CJ, Lafranchise F, Caplan LR. Safety of anticoagulation after hemorrhagic infarction. Neurology. Jul 1993;43(7):1298–303.

    CAS  PubMed  Google Scholar 

  80. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 14 Dec 2002;360(9349):1903–13.

    Article  PubMed  Google Scholar 

  81. Rashid P, Leonardi-Bee J, Bath P. Blood pressure reduction and secondary prevention of stroke and other vascular events: a systematic review. Stroke. Nov 2003;34(11):2741–8.

    Article  PubMed  Google Scholar 

  82. Chobanian AV, Bakris GL, Black HR, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 21 May 2003;289(19):2560–72.

    Article  CAS  PubMed  Google Scholar 

  83. Patrono C, Baigent C, Hirsh J, Roth G. Antiplatelet drugs: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. Jun 2008;133(6 Suppl):199S–233S.

    Article  CAS  PubMed  Google Scholar 

  84. Bennett CL, Connors JM, Carwile JM, et al. Thrombotic thrombocytopenic purpura associated with clopidogrel. N Engl J Med. 15 Jun 2000;342(24):1773–7.

    Article  CAS  PubMed  Google Scholar 

  85. Gorter JW. Major bleeding during anticoagulation after cerebral ischemia: patterns and risk factors. Stroke Prevention In Reversible Ischemia Trial (SPIRIT). European Atrial Fibrillation Trial (EAFT) study groups. Neurology. 12 Oct 1999;53(6):1319–27.

    CAS  PubMed  Google Scholar 

  86. Mohr JP, Thompson JL, Lazar RM, et al. A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke. N Engl J Med. 15 Nov 2001;345(20):1444–51.

    Article  CAS  PubMed  Google Scholar 

  87. Halkes PH, van Gijn J, Kappelle LJ, Koudstaal PJ, Algra A. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial. Lancet. 20 May 2006;367(9523):1665–73.

    Article  CAS  PubMed  Google Scholar 

  88. Bhatt DL, Fox KA, Hacke W, et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med. 20 Apr 2006;354(16):1706–17.

    Article  CAS  PubMed  Google Scholar 

  89. Diener HC, Bogousslavsky J, Brass LM, et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet. 24–30 Jul 2004;364(9431):331–7.

    Article  CAS  PubMed  Google Scholar 

  90. Diener HC, Weimar C. Update of secondary stroke prevention. Nephrol Dial Transplant. Jun 2009; 24(6):1718–24.

    Google Scholar 

  91. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP). Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 16 May 2001;285(19):2486–97.

    Google Scholar 

  92. Amarenco P. Hypercholesterolemia, lipid-lowering agents, and the risk for brain infarction. Neurology. 2001;57(5 Suppl 2):S35–44.

    CAS  PubMed  Google Scholar 

  93. Gorelick PB. Stroke prevention therapy beyond antithrombotics: unifying mechanisms in ischemic stroke pathogenesis and implications for therapy: an invited review. Stroke. Mar 2002;33(3):862–75.

    Article  PubMed  Google Scholar 

  94. Amarenco P, Bogousslavsky J, Callahan A 3rd, et al. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med. 10 Aug 2006;355(6):549–59.

    Article  CAS  PubMed  Google Scholar 

  95. FitzMaurice E, Wendell L, Snider R, et al. Effect of statins on intracerebral hemorrhage outcome and recurrence. Stroke. Jul 2008;39(7):2151–4.

    Article  CAS  PubMed  Google Scholar 

  96. Adams RJ, Albers G, Alberts MJ, et al. Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attack. Stroke. May 2008;39(5):1647–52.

    Article  PubMed  Google Scholar 

  97. Megherbi SE, Milan C, Minier D, et al. Association between diabetes and stroke subtype on survival and functional outcome 3 months after stroke: data from the European BIOMED Stroke Project. Stroke. Mar 2003;34(3):688–94.

    Article  PubMed  Google Scholar 

  98. Tuomilehto J, Rastenyte D, Jousilahti P, Sarti C, Vartiainen E. Diabetes mellitus as a risk factor for death from stroke. Prospective study of the middle-aged Finnish population. Stroke. Feb 1996;27(2):210–15.

    CAS  PubMed  Google Scholar 

  99. Karapanayiotides T, Piechowski-Jozwiak B, van Melle G, Bogousslavsky J, Devuyst G. Stroke patterns, etiology, and prognosis in patients with diabetes mellitus. Neurology. 11 May 2004;62(9):1558–62.

    PubMed  Google Scholar 

  100. Petty GW, Brown RD Jr., Whisnant JP, Sicks JD, O’Fallon WM, Wiebers DO. Survival and recurrence after first cerebral infarction: a population-based study in Rochester, Minnesota, 1975 through 1989. Neurology. Jan 1998;50(1):208–16.

    CAS  PubMed  Google Scholar 

  101. Hillen T, Coshall C, Tilling K, Rudd AG, McGovern R, Wolfe CD. Cause of stroke recurrence is multifactorial: patterns, risk factors, and outcomes of stroke recurrence in the South London stroke register. Stroke. Jun 2003;34(6):1457–63.

    Article  PubMed  Google Scholar 

  102. American Diabetes Association. ADA Clinical Practice Recommendations. Diabetes Care. 2004;27:S1–S43.

    Article  Google Scholar 

  103. Grodstein F, Stampfer MJ, Manson JE, et al. Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med. 15 Aug 1996;335(7):453–61.

    Article  CAS  PubMed  Google Scholar 

  104. Simon JA, Hsia J, Cauley JA, et al. Postmenopausal hormone therapy and risk of stroke: the Heart and Estrogen-progestin Replacement Study (HERS). Circulation. 6 Feb 2001;103(5):638–42.

    CAS  PubMed  Google Scholar 

  105. Viscoli CM, Brass LM, Kernan WN, Sarrel PM, Suissa S, Horwitz RI. A clinical trial of estrogen-replacement therapy after ischemic stroke. N Engl J Med. 25 Oct 2001;345(17):1243–9.

    Article  CAS  PubMed  Google Scholar 

  106. Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA. 17 Jul 2002;288(3):321–33.

    Article  CAS  PubMed  Google Scholar 

  107. Shinton R, Beevers G. Meta-analysis of relation between cigarette smoking and stroke. Bmj. 25 Mar 1989;298(6676):789–94.

    Article  Google Scholar 

  108. Wolf PA, D’Agostino RB, Kannel WB, Bonita R, Belanger AJ. Cigarette smoking as a risk factor for stroke. The framingham study. JAMA. 19 Feb 1988;259(7):1025–9.

    Article  CAS  PubMed  Google Scholar 

  109. Wannamethee SG, Shaper AG, Whincup PH, Walker M. Smoking cessation and the risk of stroke in middle-aged men. JAMA. 12 Jul 1995;274(2):155–60.

    Article  CAS  PubMed  Google Scholar 

  110. The Tobacco Use and Dependence Clinical Practice Guideline and Consortium Representatives. A clinical practice guideline for treating tobacco use and dependence: a US Public Health Service report. The tobacco use and dependence clinical practice guideline panel, staff, and consortium representatives. JAMA. 28 Jun 2000;283(24):3244–54.

    Article  Google Scholar 

  111. Reynolds K, Lewis B, Nolen JD, Kinney GL, Sathya B, He J. Alcohol consumption and risk of stroke: a meta-analysis. JAMA. 5 Feb 2003;289(5):579–88.

    Article  PubMed  Google Scholar 

  112. Gill JS, Zezulka AV, Shipley MJ, Gill SK, Beevers DG. Stroke and alcohol consumption. N Engl J Med. 23 Oct 1986;315(17):1041–6.

    Article  CAS  PubMed  Google Scholar 

  113. Lee IM, Hennekens CH, Berger K, Buring JE, Manson JE. Exercise and risk of stroke in male physicians. Stroke. Jan 1999;30(1):1–6.

    CAS  PubMed  Google Scholar 

  114. Wannamethee SG, Lowe GD, Whincup PH, Rumley A, Walker M, Lennon L. Physical activity and hemostatic and inflammatory variables in elderly men. Circulation. 16 Apr 2002;105(15):1785–90.

    Article  PubMed  Google Scholar 

  115. Gordon NF, Gulanick M, Costa F, et al. Physical activity and exercise recommendations for stroke survivors: an American Heart Association scientific statement from the Council on Clinical Cardiology, Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention; the Council on Cardiovascular Nursing; the Council on Nutrition, Physical Activity, and Metabolism; and the Stroke Council. Stroke. May 2004;35(5):1230–40.

    Article  PubMed  Google Scholar 

  116. Adams HP, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24:35–41.

    Google Scholar 

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Correspondence to Laura Pedelty MD, PhD .

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Pedelty, L. (2011). A Practical Guide to Recurrent Stroke Prevention. In: Aiyagari, V., Gorelick, P. (eds) Hypertension and Stroke. Clinical Hypertension and Vascular Diseases. Humana Press. https://doi.org/10.1007/978-1-60761-010-6_11

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