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Stem Cells and Cancer pp 217–230Cite as

Prostate Cancer Stem/Progenitor Cells

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

The cancer stem cell (CSC) theory posits that only a small population of tumor cells within the tumor has the ability to reinitiate tumor development and is responsible for tumor homeostasis and progression. Tumor initiation is a defining property of putative CSCs, which have been reported in both blood malignancies and solid tumors. Here we provide evidence that both cultured prostate cancer cells and xenograft prostate tumors contain stem-like cells that can initiate serially transplantable tumors. We also present a hypothetical model of tumorigenic hierarchy of cancer cells in prostate tumors. Further studies on these important tumorigenic cells will help to understand prostate tumor biology and to develop novel diagnostic and prognostic markers and therapeutic agents.

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ACKNOWLEDGMENTS

We thank Mr. Kent Claypool for assistance in FACS, Histology and Animal Facility Cores for technical assistance, and other members (past and present) of the Tang lab for discussion and support. This work was supported in part by grants from NIH (R01-AG023374, R01ES015888, and R21-ES015893–01A1), American Cancer Society (RSG MGO-105961), Department of Defense (W81XWH-07–1–0616 and PC073751), Prostate Cancer Foundation, and Elsa Pardee Foundation (D.G.T), and by two Center grants (CCSG-5 P30 CA166672 and ES07784). H. Li was supported in part by a predoctoral fellowship from DOD (W81XWH-07-1-0132).

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  1. Department of Carcinogenesis, University of Texas M.D Anderson Cancer Center, Science Park-Research Division, 1808 Park Road, 1-C, 389, 78957, Smithville, TX, USA

    Sofia Honorio, Hangwen Li & Dean G. Tang

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  1. Sofia Honorio
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  2. Hangwen Li
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  3. Dean G. Tang
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Correspondence to Dean G. Tang .

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    Honorio, S., Li, H., Tang, D. (2009). Prostate Cancer Stem/Progenitor Cells. In: Teicher, B., Bagley, R. (eds) Stem Cells and Cancer. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-60327-933-8_17

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