Abstract
Corticobasal degeneration (CBD) is a clinically heterogeneous disorder associated with characteristic neuropathologic findings. These include cortical and nigral atrophy, numerous swollen cortical neurons, and tau-immunoreactive astrocytic plaques which are not present in other tauopathies. Classically, CBD patients present in the sixth to eighth decade with a myriad of motor manifestations including limb dystonia, focal reflex myoclonus, postural/action tremor, and akinetic rigidity; cerebral cortical deficits including cortical sensory loss, apraxia, an alien limb phenomenon, and aphasia; and other clinical features such as oculomotor apraxia and corticospinal tract signs.
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19 Corticobasal Degeneration.mp4 (MP4 20,026KB)
Clip 1: this patient with CBS exhibits dystonia with a fixed adducted and flexed posture of her right arm, hand, and fingers. When testing for apraxia, the patient was able to show her left arm and left two fingers. She was unable to perform these tasks on the right side due to the severe dystonia. She was able to locate her right arm with her left hand. Clip 2: another patient with CBS displays a fixed, dystonic posture of the right hand.
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Bhidayasiri, R., Tarsy, D. (2012). Corticobasal Degeneration. In: Movement Disorders: A Video Atlas. Current Clinical Neurology. Humana, Totowa, NJ. https://doi.org/10.1007/978-1-60327-426-5_19
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DOI: https://doi.org/10.1007/978-1-60327-426-5_19
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Publisher Name: Humana, Totowa, NJ
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