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Cytokines in the Genesis and Treatment of Cancer pp 27–51Cite as

HTLV-1, Cytokines,and Cancer

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Human T-cell lymphotropic virus type 1 (HTLV-1), is the causative agent of adult T-cell leukemia/lymphoma (ATLL) and a variety of immune-mediated disorders (Table 1). Currently, HTLV-1 infection occurs worldwide with endemic regions of higher prevalence. Natural transmission of these viruses occurs through cell-associated routes that include: orally from breast feeding, sexual contact, and by exposure to infected blood or whole cell blood products. While the molecular events of virus replication are beginning to be unraveled and knowledge about HTLV-1-associated diseases has increased, there remain many questions regarding the pathogenesis of the diseases associated with this complex retrovirus. In this chapter, we will focus on the pathogenesis and clinical presentation of ATLL with emphasis on new information regarding the viral etiology, pathologic lesions, patient susceptibility factors, host immune responses, and, in particular, the role of cytokines in the development of ATLL. The epidemiology and diseases associated with HTLV-1 are well known; however, the molecular mechanisms used by the virus to establish persistent infection and subsequently facilitate lymphocyte proliferation while circumventing immune elimination, remain less well defined.

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Authors and Affiliations

  1. Department of Veterinary Biosciences, The Ohio State University, Columbus, OH

    Michael D. Lairmore DVM, PHD (Professor and Chair)

  2. Department of Medicine, Pathology, and Molecular Microbiology, Washington University School of Medicine, St. Louis, MO

    Lee Ratner MD, PHD

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  1. Michael D. Lairmore DVM, PHD
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  2. Lee Ratner MD, PHD
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Editors and Affiliations

  1. The Ohio State University Comprehensive Cancer Center, Columbus, OH

    Michael A. Caligiuri MD

  2. University of Pittsburgh Cancer Center, Pittsburgh, PA

    Michael T. Lotze MD (Director) (Director)

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Lairmore, M.D., Ratner, L. (2007). HTLV-1, Cytokines,and Cancer. In: Caligiuri, M.A., Lotze, M.T. (eds) Cytokines in the Genesis and Treatment of Cancer. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-455-1_2

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