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Nutrition and Rheumatic Disease pp 125–158Cite as

Nutrition and Nutritional Supplements and Osteoarthritis

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Part of the book series: Nutrition and Health ((NH))

Summary

• There are numerous mechanisms by which micronutrients might be expected to influence the development or progression of osteoarthritis, but there has been insufficient research to draw definitive conclusions

• One observational study suggested a protective effect of vitamin C for progression of osteoarthritis of the knee. Intake of vitamin E and β-carotene bore no relationship to osteoarthritis incidence or progression in that study, suggesting that the mechanism of benefit of vitamin C may be mediated through nonantioxidant properties

• Clinical trials of vitamins E, C, and A and selenium have produced negative or inconsistent results

• Epidemiological data for vitamin D in the treatment of symptoms and structural progression of osteoarthritis are conflicting. A randomized controlled trial is currently underway to address the efficacy of vitamin D in both the treatment of symptoms and structural progression in osteoarthritis.

• Epidemiological data for vitamin K as a disease modifying micronutrient in osteoarthritis are conflicting. Randomized controlled trials are currently underway to address the efficacy of vitamin K in both the treatment of symptoms and structural progression in osteoarthritis.

• There have been numerous positive clinical trials of glucosamine and chondroitin products for OA that have shown them to be well tolerated; however, interpretation of these trials is clouded by issues of biological plausibility, heterogeneity, publication bias, inconsistent results and methodological problems.

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  1. Paola de Pablo
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  2. Grace Lo
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  1. Marshfield Clinic Research Foundation, Marshfield, WI

    Laura A. Coleman PhD, RD

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Pablo, P.d., Lo, G., McAlindon, T.E. (2008). Nutrition and Nutritional Supplements and Osteoarthritis. In: Coleman, L.A. (eds) Nutrition and Rheumatic Disease. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-59745-403-2_8

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