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Hereditary Factors in Endometrial Cancer

  • Chapter
Book cover Molecular Pathology of Gynecologic Cancer

Part of the book series: Current Clinical Oncology ((CCO))

Abstract

Over 40,000 cases of endometrial cancer (EC) accounting for more than 7000 deaths occur in the United States each year (1). About 10–15% of these cases are found in family clusters, of which approx 7% will have a clear-cut hereditary etiology. The majority of hereditary EC cases are found in families with the Lynch syndrome, also called hereditary nonpolyposis colorectal cancer (HNPCC) syndrome (2, 3). Other extracolonic cancers of the Lynch syndrome include carcinomas of the ovary, stomach, small bowel, hepatobiliary tract, pancreas, breast, brain, and transitional cell carcinoma of the ureter and renal pelvis (4). Figure 1 shows two pedigrees that depict typical Lynch syndrome families with EC in the direct genetic lineage. The purpose of this chapter is to describe hereditary EC, its phenotypical features, molecular genetics, pathology, diagnosis, and management strategies.

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Authors and Affiliations

  1. Medical Oncology and Genetic Consultation, Department of Preventive Medicine, Creighton University School of Medicine, Omaha, NE

    Henry T. Lynch MD

  2. Department of Obstetrics and Gynecology, Creighton University School of Medicine, Omaha, NE

    Murray Joseph Casey MD

  3. Department of Preventive Medicine, Creighton University School of Medicine, Omaha, NE

    Joseph A. Knezetic PhD & Jane E. Lynch BSN

  4. Medical Oncology and Genetic Consultation, Creighton University School of Medicine, School of Medicine, Omaha, NE

    Trudy G. Shaw MA

  5. Department of Pathology, Creighton University Medical Center, Omaha, NE

    Chhanda Bewtra MD

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  1. Henry T. Lynch MD
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  2. Murray Joseph Casey MD
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  4. Trudy G. Shaw MA
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Editors and Affiliations

  1. Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA

    Antonio Giordano MD, PhD  & Alessandro Bovicelli MD, PhD  & 

  2. Departments of Human Pathology and Oncology, University of Siena, Siena, Italy

    Antonio Giordano MD, PhD

  3. Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy

    Alessandro Bovicelli MD, PhD

  4. Departments of Gynecology-Obstetrics and Pathology, Johns Hopkins University, Baltimore, MD

    Robert J. Kurman MD, PhD

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Lynch, H.T., Casey, M.J., Knezetic, J.A., Shaw, T.G., Lynch, J.E., Bewtra, C. (2007). Hereditary Factors in Endometrial Cancer. In: Giordano, A., Bovicelli, A., Kurman, R.J. (eds) Molecular Pathology of Gynecologic Cancer. Current Clinical Oncology. Humana Press. https://doi.org/10.1007/978-1-59745-346-2_12

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