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Computational Genetics and Genomics pp 199–252Cite as

Murine Models of Alcoholism

From QTL to Gene

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Abstract

Most behavioral responses to alcohol are known to be influenced by genetic factors. Human twin and adoption studies consistently show that susceptibility to alcohol abuse is heritable (1). The mode of inheritance is unknown, but is certainly polygenic and multifactorial, with a substantial environmental effect (1,2). Despite much research, the genes and causal pathways determining susceptibility to alcohol abuse and dependence remain relatively unknown. Identifying genes that mediate alcoholism will improve strategies for diagnosis, treatment, and ultimately prevention.

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  1. Institute for Behavioral Genetics, University of Colorado, Boulder, CO

    Chris Downing, Beth Bennett & Thomas E. Johnson

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  1. Department of Genetics and Genomics, Roche Palo Alto, Palo Alto, CA

    Gary Peltz MD, PhD

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Downing, C., Bennett, B., Johnson, T.E. (2005). Murine Models of Alcoholism. In: Peltz, G. (eds) Computational Genetics and Genomics. Humana Press. https://doi.org/10.1007/978-1-59259-930-1_9

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