Abstract
IgG4-related disease (IgG4-RD) is a recently recognized systemic immune-mediated disease, typically characterized by mass-forming fibroinflammatory lesions that may affect nearly any organ. In the kidney, IgG4-RD is most often manifested as IgG4-related tubulointerstitial nephritis (IgG4-TIN), which can present as mass lesions, renal insufficiency, or both. IgG4-TIN has a histologic appearance to other organs involved by IgG4-RD and shows a plasma cell-rich tubulointerstitial nephritis with “storiform” fibrosis; most cases also show tubular basement membrane immune complex deposits, which is a helpful feature on biopsy. IgG4-TIN, like fibroinflammatory manifestations of IgG4-RD in other organs, typically shows a brisk response to steroid therapy, although there is a high relapse rate. Glomerular involvement by IgG4-RD, especially membranous glomerulonephritis, has been recognized more recently.
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Cornell, L.D. (2014). Renal Involvement by IgG4-Related Disease. In: Fervenza, F., Lin, J., Sethi, S., Singh, A. (eds) Core Concepts in Parenchymal Kidney Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8166-9_17
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DOI: https://doi.org/10.1007/978-1-4614-8166-9_17
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