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Genetic Variants in Alzheimer's Disease

  • Book
  • © 2013

Overview

Editors:
  1. Kevin Morgan

    1. Queen's Medical Centre, School of Molecular Medical Sciences, University of Nottingham, Nottingham, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  2. Minerva M. Carrasquillo

    1. , Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • The aim of this book is to put all of the recent genetic data on these new genes into context

  • New genetics of Alzheimer’s disease

  • Different genetic variants are discussed, as well as biomarkers and future possibilities ?

  • Includes supplementary material: sn.pub/extras

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
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  2. The Genetics of Alzheimer’s Disease: Introduction and Perspective for the Future

    • Kevin Morgan, Minerva M. Carrasquillo
    Pages 1-5

  3. Apolipoprotein E

    • Minerva M. Carrasquillo, Guojun Bu, Henrietta M. Nielsen
    Pages 7-23

  4. Clusterin

    • Jenny Lord, Kevin Morgan
    Pages 25-51

  5. PICALM

    • Jenny Lord, Kevin Morgan
    Pages 53-76

  6. Complement Component (3b/4b) Receptor 1 (CR1)

    • Jenny Lord, Kevin Morgan
    Pages 77-101

  7. Bridging Integrator 1 (BIN1)

    • James Turton, Kevin Morgan
    Pages 103-133

  8. ATP-Binding Cassette, Subfamily A (ABC1), Member 7 (ABCA7)

    • James Turton, Kevin Morgan
    Pages 135-158

  9. Membrane-Spanning 4-Domains Subfamily A, MS4A Cluster

    • Kristelle Brown, James Turton, Kevin Morgan
    Pages 159-179

  10. Sialic Acid Binding Immunoglobulin-Like Lectin-3 (CD33)

    • Christopher Medway, Kevin Morgan
    Pages 181-190

  11. Erythropoietin-Producing Human Hepatocellular Carcinoma (EphA1)

    • Christopher Medway, Anne Braae, Kevin Morgan
    Pages 191-199

  12. CD2-Associated Protein (CD2AP)

    • Christopher Medway, Kevin Morgan
    Pages 201-208

  13. Other Genes Implicated in Alzheimer’s Disease

    • Minerva M. Carrasquillo, Mariet Allen, Nilüfer Ertekin-Taner
    Pages 209-230

  14. The Future Role of Biomarkers in Alzheimer’s Disease Diagnostics

    • Joanna L. Richens, Bharak Vafadar-Isfahani, Kelly-Ann Vere, Graham Ball, Noor Kalsheker, Robert Rees et al.
    Pages 231-248

  15. Back Matter

    Pages 249-254
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Keywords

About this book

Alzheimer’s Disease is the most common form of dementia. The disease is characterised by the loss of synapses and neurons in the cerebral cortex and certain subcortical regions. In the last three years, the genetics of Alzheimer’s Disease has made significant advances; in fact, one could argue more than in the previous two decades.  This has resulted in the identification of nine new genes and perhaps more importantly the realization that new pathways could be involved in the pathogenesis of Alzheimer’s.  These new pathways are now legitimate targets for therapeutic intervention, which can possibly lead to treatment or a possible cure.  The aim of this book is to put all of the recent genetic data on these new genes into context.  Different genetic variants will be discussed, as well as biomarkers and future possibilities. ​

Editors and Affiliations

  • Queen's Medical Centre, School of Molecular Medical Sciences, University of Nottingham, Nottingham, United Kingdom

    Kevin Morgan

  • , Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, USA

    Minerva M. Carrasquillo

Bibliographic Information

  • Book Title: Genetic Variants in Alzheimer's Disease

  • Editors: Kevin Morgan, Minerva M. Carrasquillo

  • DOI: https://doi.org/10.1007/978-1-4614-7309-1

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2013

  • Hardcover ISBN: 978-1-4614-7308-4Published: 22 June 2013

  • Softcover ISBN: 978-1-4899-9799-9Published: 08 July 2015

  • eBook ISBN: 978-1-4614-7309-1Published: 22 June 2013

  • Edition Number: 1

  • Number of Pages: VIII, 254

  • Topics: Human Genetics, Neurosciences, Gene Function

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