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Stress-Induced Mutagenesis pp 257–270Cite as

Revisiting Mutagenesis in the Age of High-Throughput Sequencing

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Abstract

Mutagenesis is a fundamental biological process by which changes in DNA sequences occur in vivo. On one hand, mutagenesis facilitates adaptation and drives evolution, and on the other hand it leads to diseases such as cancer. Recent advances in high-throughput DNA-sequencing technologies, coupled with efficient bioinformatics tools, have allowed analyses of genomic data at an unprecedented scale. These emerging sequencing technologies have not only helped speed up genome analyses; they have also provided novel insights into mutagenesis and its implications for evolution, diseases, and biotechnology. The versatility of these technologies has initiated a new paradigm of biological research in diverse areas of research such as microbiology, evolutionary biology, human genetics and cancer.

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Authors and Affiliations

  1. Department of Medicine, University of Colorado School of Medicine and University of Colorado Cancer Center, Aurora, CO, 80045, USA

    Subhajyoti De

  2. Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, 24061, USA

    R. Matthew Ward

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  1. Subhajyoti De
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  2. R. Matthew Ward
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Correspondence to Subhajyoti De .

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  1. , Department of Biological Sciences, Virginia Tech, 4100 Derring Lab, Blacksburg, 24061, Virginia, USA

    David Mittelman

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De, S., Ward, R.M. (2013). Revisiting Mutagenesis in the Age of High-Throughput Sequencing. In: Mittelman, D. (eds) Stress-Induced Mutagenesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6280-4_13

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