Abstract
Human immunodeficiency virus (HIV) is a lymphotropic retrovirus that infects a subset of cells within the immune system. As HIV infection progresses, the ability of the immune system to detect and suppress a variety of conditions such as cancer and infections is impaired. Here, we present a case of B-cell lymphoma as the initial presentation of HIV infection as well as a case of histoplasmosis secondary to HIV infection presenting as a colonic mass.
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Campsmith ML, Rhodes PH, Hall HI, Green TA. Undiagnosed HIV prevalence among adults and adolescents in the United States at the end of 2006. J Acquir Immune Defic Syndr. 2010;53(5):619–24.
Van Baarle D, Hovenkamp E, Callan MFC, Wolthers KC, Kostense S, Tan LC, et al. Dysfunctional Epstein-Barr Virus (EBV)-specific CD8+ T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hodgkin lymphoma. Blood. 2001;98(1):146–55.
Epeldegui M, Vendrame E, Martínez-Maza O. HIV-associated immune dysfunction and viral infection: role in the pathogenesis of AIDS-related lymphoma. Immunol Res. 2010;48(1):72–83.
Girard T, Luquet-Besson I, Baran-Marszak F, Raphaël M, Boué F. HIV + MALT lymphoma remission induced by highly active antiretroviral therapy alone. Eur J Haematol. 2005;74(1):70–2.
Kaplan LD, Lee JY, Ambinder RF, Sparano JA, Cesarman E, Chadburn A, et al. Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium Trial 010. Blood. 2005;106(5):1538–43.
Sparano JA, Lee JY, Kaplan LD, Levine AM, Ramos JC, Ambinder RF, et al. Rituximab plus concurrent infusional EPOCH chemotherapy is highly effective in HIV-associated B-cell non-Hodgkin lymphoma. Blood. 2010;115(15):3008–16.
Kahi CJ, Wheat LJ, Allen SD, Sarosi GA. Gastrointestinal histoplasmosis. Am J Gastroenterol. 2005;100(1):220–31.
Tadokera R, Meintjes G, Skolimowska KH, Wilkinson KA, Matthews K, Seldon R, et al. Hypercytokinaemia accompanies HIV–tuberculosis immune reconstitution inflammatory syndrome. Eur Respir J. 2011;37(5):1248–59.
Mahnke YD, Greenwald JH, DerSimonian R, Roby G, Antonelli LRV, Sher A, et al. Selective expansion of polyfunctional pathogen-specific CD4+ T cells in HIV-1-infected patients with immune reconstitution inflammatory syndrome. Blood. 2012;119(13):3105–12.
Abdool Karim SS, Naidoo K, Grobler A, Padayatchi N, Baxter C, Gray A, et al. Timing of initiation of antiretroviral drugs during tuberculosis therapy. N Engl J Med. 2010;362(8):697–706.
Chessman D, Kostenko L, Lethborg T, Purcell AW, Williamson NA, Chen Z, et al. Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity. Immunity. 2008;28(6):822–32.
Mallal S, Phillips E, Carosi G, Molina J-M, Workman C. HLA-B*5701 screening for hypersensitivity to abacavir. N Engl J Med. 2008;358(6):568–79.
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Soltani, B., Samuel, R., Bettiker, R. (2013). HIV and AIDS. In: Mahmoudi, M. (eds) Challenging Cases in Rheumatology and Diseases of the Immune System. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5088-7_15
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DOI: https://doi.org/10.1007/978-1-4614-5088-7_15
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