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Mitochondria and Their Role in Cardiovascular Disease pp 3–11Cite as

Introduction to Mitochondria in the Heart

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Abstract

In this introductory chapter to Mitochondria Role in Cardiovascular Diseases, we will discuss those primary defects in mitochondrial and nuclear genomes that cause alterations in major aspects of mitochondrial metabolism. They include defects in OXPHOS and TCA cycle activity and regulation, mitochondrial membrane proteins, channels and transporters, transcription, translation and posttranslation modification factors, mitochondrial ribosomal proteins, mtDNA replication and repair, as well as mitochondrial dynamic. How these defects contribute to pathogenesis of cardiovascular diseases will be described in detail later in dedicated chapters.

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  1. The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA

    José Marín-García M.D.

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Marín-García, J. (2013). Introduction to Mitochondria in the Heart. In: Mitochondria and Their Role in Cardiovascular Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4599-9_1

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