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Exercise, Energy Balance, and Cancer pp 59–81Cite as

Biological Pathways Impacting Cancer Survival: Exercise as a Countermeasure for the Development and Progression of Cachexia

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Part of the book series: Energy Balance and Cancer ((EBAC,volume 6))

Abstract

This chapter will illustrate the signaling pathways that are influenced by exercise that could impact cancer patient survival as it relates to the treatment and prevention of cachexia. Cancer cachexia involves an unintentional body weight loss, which includes muscle and fat mass loss. Cachexia is most prevalent with cancers of the colon, lung and pancreas, and the development of cachexia coincides with increased patient morbidity, mortality, and a reduction in quality of life. This chapter will focus on the ability of exercise to improve an environment that involves suppressed anabolic signaling pathways, activated catabolic signaling pathways, and disrupted metabolic signaling. These changes will be considered in terms of the impact of processes involved in local and systemic metabolism. Exercise will be examined in respect to both acute changes and chronic exercise adaptations. Additionally, the complexity of this biological response as it pertains to the intensity and duration of exercise will be highlighted.

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Acknowledgements

We would like to acknowledge Dr. Robert Price (University of South Carolina School of Medicine) for assisting with the electron microscopy images. This work is supported by the National Institutes of Health (NCI) RO1CA121249 to James Carson.

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Authors and Affiliations

  1. Applied Physiology Division/Exercise Science Department, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA

    James A. Carson Ph.D., FACSM & Melissa J. Puppa

  2. University of South Carolina Applied Physiology Division/Exercise Science Department, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA

    James A. Carson Ph.D., FACSM & Melissa J. Puppa

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Correspondence to James A. Carson Ph.D., FACSM .

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    Cornelia M. Ulrich

  2. Heidelberger Str. 35, Schriesheim, 69198, Germany

    Karen Steindorf

  3. School of Medicine, Center for Science, Health & Society, Case Western Reserve University, Euclid Ave. 10900, Cleveland, 44106, Ohio, USA

    Nathan A. Berger

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Carson, J.A., Puppa, M.J. (2013). Biological Pathways Impacting Cancer Survival: Exercise as a Countermeasure for the Development and Progression of Cachexia. In: Ulrich, C., Steindorf, K., Berger, N. (eds) Exercise, Energy Balance, and Cancer. Energy Balance and Cancer, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4493-0_5

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  • DOI: https://doi.org/10.1007/978-1-4614-4493-0_5

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