Abstract
Research on adenosine has a long history, and since the beginning more than 80 years ago there has been a link to energy metabolism. This is due to the fact that levels of adenosine increase under conditions of relative energy deficiency and that adenosine can have actions that limit this: increase respiration, increase blood flow, and reduce cellular work. There are also effects on intermediary metabolism and on overall energy homeostasis. This minireview provides a brief and personal historical background to these developments.
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Acknowledgments
In writing this I have repeatedly consulted an unpublished review by R.A. Olsson, A History of Adenosine Research. I am most grateful to him for letting me read it. I am also grateful to numerous coworkers.
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Fredholm, B.B. (2013). Adenosine and Metabolism—A Brief Historical Note. In: Masino, S., Boison, D. (eds) Adenosine. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3903-5_1
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