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Animal Models of Orthopedic Implant-Related Infection

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Book cover Biomaterials Associated Infection

Abstract

Musculoskeletal infection remains a great challenge in orthopedic and trauma surgery. Despite best medical and surgical practice and significant advances in research and development, bone and implant associated infections are still difficult to diagnose, impossible to prevent in all cases and require invasive and debilitating treatment. The development and safe clinical implementation of novel preventative, therapeutic or diagnostic strategies requires the use of animal models of infection, which provide crucial evidence regarding performance, cytocompatibility, biocompatibility, and safety prior to clinical implementation.

Many animal models of musculoskeletal infection have been described in the literature; however, there remains a dearth of fully standardized or universally accepted reference models hindering advancement in the field. The following chapter provides an overview of the animal models available for the study of musculoskeletal infection, the latest advances that are expected to improve them, and some of the most important scientific output achieved using these models.

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Authors and Affiliations

  1. AO Research Institute Davos, Clavadelerstrasse 9, CH7270, Davos, Switzerland

    Lorenzo Calabro, Cameron Lutton, Ahmed Fouad Seif El Din, R. Geoff Richards & T. Fintan Moriarty

  2. Queensland University of Technology, Brisbane, Australia

    Lorenzo Calabro

  3. Orthopaedic Surgery and Trauma Department, Kasr Al-Ainy Cairo University Hospitals, Cairo, Egypt

    Ahmed Fouad Seif El Din

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  1. Lorenzo Calabro
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  2. Cameron Lutton
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  3. Ahmed Fouad Seif El Din
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  4. R. Geoff Richards
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  5. T. Fintan Moriarty
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Correspondence to Lorenzo Calabro .

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  1. AO Research Institute Davos, Clavadelerstrasse 8, Davos Platz, 7270, Switzerland

    T. Fintan Moriarty

  2. , Medical Microbiology, Academic Medical Center, Meibergdreef 15, Amsterdam, 1105 AZ, Netherlands

    Sebastian A.J. Zaat

  3. University Medical Center Groningen, A. Deusinglaan 1, Groningen, 9713 AV, Netherlands

    Henk J. Busscher

Glossary

Implant-related Osteomyelitis

Osteomyelitis occurring associated with an ­implant, most commonly prosthetic joint replacements or fracture fixation devices.

Osteomyelitis

Osteomyelitis is an acute or chronic infection of the bone or bone marrow.

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Calabro, L., Lutton, C., Din, A.F.S.E., Richards, R.G., Moriarty, T.F. (2013). Animal Models of Orthopedic Implant-Related Infection. In: Moriarty, T., Zaat, S., Busscher, H. (eds) Biomaterials Associated Infection. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1031-7_12

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