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Tumour-Associated Macrophages pp 3–16Cite as

Macrophage Phenotype in Tumours

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Abstract

Macrophages are often present in tumours, display considerable heterogeneity in phenotype, and contribute trophic, tumour-promoting functions that favour clonal emergence, growth and spread of malignant cells, as well as contributing to host tolerance and stromal reactions. Membrane glycoproteins provide antigenic markers, serve as receptors for tumour-derived ligands, and regulate macrophage–tumour interactions. We review selected aspects of macrophage phenotypic heterogeneity, with special reference to novel markers such as the EGF-TM7 family of myeloid differentiation antigens. Improved characterisation of macrophage plasticity may make it possible to manipulate macrophage effector functions to the advantage of the host.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, Taiwan

    Hsi-Hsien Lin

  2. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK

    Siamon Gordon

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  1. Hsi-Hsien Lin
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  2. Siamon Gordon
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Correspondence to Siamon Gordon .

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Editors and Affiliations

  1. Inserm-CNRS-Universitie de Mediteranee, Inflammation Biology Group, Centre d'Immunologie Marseille Luminy, Parc Scientifique de Luminy, Case 906, Marseille, Cedex 9, France

    Toby Lawrence

  2. Barts & The London Queen Mary's, School of Medicine & Dentistry, Queen Mary, University of London, Charterhouse Square, London, EC1M 6BQ, United Kingdom

    Thorsten Hagemann

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Lin, HH., Gordon, S. (2011). Macrophage Phenotype in Tumours. In: Lawrence, T., Hagemann, T. (eds) Tumour-Associated Macrophages. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0662-4_1

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