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Research Studies in Wound Healing: The Role of Outcomes/Endpoints for the Evidence in RCTs

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Abstract

Different types of measurements are used in the research studies in wound healing primarily RCTs. Some of the most important measures in wound healing research: outcomes/endpoints.

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References

  1. Gottup F, Appelqvist J, Price P. Outcomes in controlled and comparative studies on non-healing wounds: recommendations to improve the quality of evidence in wound management. J Wound Care. 2010;19:237–68.

    Google Scholar 

  2. Matousek S, Deva AK, Mani R. Outcome measurements in wound healing are not inclusive: a way forward. Int J Low Extrem Wounds. 2007;6:284–90.

    Article  PubMed  CAS  Google Scholar 

Suggested Readings

  • Bell-Syer S, Brady M, Bruce J, Cullum N, Foxlee R, Jull A, Margolis D, Mclnnes L, Nelson A, ÓMeara S, Ubbink D. Letter: evidence-based wound care in the UK: a response to David Leapers Editorial in International Wound Journal April 2009 6(2). Int Wound J. 2009;6:306–9.

    Article  PubMed  Google Scholar 

  • Biancari F, Salenius JP, Heikkinen M, Luther M, Ylönen K, Lepäntalo M. Risk-scoring method for prediction of 30-day ostoperative outcome after infrainguinal surgical revascularization for critical lower-limb ischemia: a Finnvasc registry study. World J Surg. 2007;31:217–25.

    Article  PubMed  Google Scholar 

  • Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001;69:89–95.

    Article  Google Scholar 

  • Bouza C, Munoz A, Amata JM. Efficacy of modern dressings in the treatment of leg ulcers: a systematic review. Wound Repair Regen. 2005;13:218–29.

    Article  PubMed  Google Scholar 

  • Briggs M, Closs SJ. Patients’ perceptions of the impact of treatments and products on their pain experience of leg ulcer pain. J Wound Care. 2006;15(8):333–7.

    PubMed  CAS  Google Scholar 

  • Chaby G, Senet P, Veneau M, et al. Dressings for acute and chronic wounds. A systematic review. Arch Dermatol. 2007;143:1297–304.

    Article  PubMed  Google Scholar 

  • Carter MJ. Evidence-based medicine: an overview of key concepts. Ostomy Wound Manage. 2010;56:68–85.

    PubMed  Google Scholar 

  • De Gruttola VG, et al. Considerations in the evaluation of surrogate endpoints in clinical trials: summary of a National Institutes of Health Workshop. Control Clin Trials. 2001;22:485–502.

    Article  PubMed  Google Scholar 

  • Drummond MF, Schulpher MJ, Torrance GW, O’Brien BJ, Stoddart GL. Methods for the economic evaluation of health care programmes. 3rd ed. Oxford: Oxford University Press; 2005.

    Google Scholar 

  • Enoch S, Price PE. Cellular, molecular and biochemical differences in the pathophysiology of healing between acute wounds, chronic wounds, and wounds in the aged. World wide wounds. 2004. Available from www.worldwidewounds.com//2004/august/Enoch/Pathophysiology-Of-Healing.html. Accessed 15 January 2010.

  • Falanga V, Saap LJ, Ozonoff A. Wound bed score and its correlation with healing of chronic wounds. Dermatol Ther. 2006;19:383–90.

    Article  PubMed  Google Scholar 

  • Gershatar M, Apelqvist J, Eneroth M, Larsson J, Nyberg P, Thörne J. Complexity of factors related to outcome of neuropathic and neuroischemic/ischemic diabetic foot ulcers; a cohort study. Diabetologia. 2009;52(3):398–407.

    Article  Google Scholar 

  • Gottrup F. Evidence is a challenge in wound management. Editorial. Lower extremity wounds. Int J Low Extrem Wounds. 2006;5:274–5.

    Article  Google Scholar 

  • Gottrup F, Apelqvist J. The challenge of using randomized trials in wound healing. Br J Surg. 2010;97:303–4.

    Article  PubMed  CAS  Google Scholar 

  • Grey JE, Leaper D, Harding K. How to measure success in treating chronic leg ulcers (editorial). BMJ. 2009;338:b1434.

    Article  PubMed  Google Scholar 

  • Hinchliffe RJ, Valk GD, Apelqvist J, Armstrong DG, Bakker K, Game FL, et al. A systematic review of the effectiveness of interventions to enhance the healing of chronic ulcers of the foot in diabetes. Diabetes Metab Res Rev. 2008;24 Suppl 1:S119–44.

    Article  PubMed  Google Scholar 

  • Horkan L, Stansfield G, Miller M. An analysis of systematic reviews undertaken on standard advanced wound dressings in the last 10 years. J Wound Care. 2009;18(7):298–304.

    PubMed  CAS  Google Scholar 

  • Leaper D. Evidence based wound care in the UK (editorial). Int Wound J. 2009;6:89–91.

    Article  PubMed  Google Scholar 

  • Levine S, Petra N, Theresa R. Effectiveness guidance document: methodological guidance for the design of comparative effectiveness studies, devices for local treatment of chronic wounds., CMTP Center for Medical Technology Policy, Version 1.0 Published Aug 2009.

    Google Scholar 

  • Lipsky BA, Polis AB, Lantz KC, Norquist JM, Abramson MA. The value of a wound score for diabetic foot infections in predicting treatment outcome: a prospective analysis from the SIDESTEP trial. Wound Repair Regen. 2009;17(5):671–7.

    Article  PubMed  Google Scholar 

  • Little C, McDonald J, Jenkins MG, McCarron P. An overview of techniques used to measure wound area and volume. J Wound Care. 2009;18:250–3.

    PubMed  CAS  Google Scholar 

  • Moore K, McCallion R, Searle RJ, Stacey MC, Harding KG. Prediction and monitoring the therapeutic response of chronic dermal wounds. Int Wound J. 2006;3:89–96.

    Article  PubMed  Google Scholar 

  • Palfreyman S, Nelson EA, Michaels JA. Dressings for venous leg ulcers: systematic review and meta-analysis. BMJ. 2007;335:244.

    Article  PubMed  Google Scholar 

  • Peinemann F, McGauran N, Sauerland S, Lange S. Negative pressure wound therapy: potential publication bias caused by lack of access to unpublished study results data. BMC Med Res Methodol. 2008;8:4.

    Article  PubMed  Google Scholar 

  • Penhallow K. A review of studies that examine the impact of infection on the normal wound-healing process. J Wound Care. 2005;14:123–6.

    PubMed  CAS  Google Scholar 

  • Persoon A, Heinen MM, van der Vleuten CJ, de Rooij MJ, van de Kerkhof PC, van Achterberg T. Leg ulcers: a review of their impact on daily life. J Clin Nurs. 2004;13(3):341–54.

    Article  PubMed  Google Scholar 

  • Posnett J, Gottrup F, Lundgren H, Saal G. The resource impact of wounds on health-care providers in Europe. J Wound Care. 2009;18:154–61.

    PubMed  CAS  Google Scholar 

  • Price PE, Fagervik-Morton H, Mudge EJ, Beele H, Ruiz JC, Nystrøm TH, Lindholm C, Maume S, Melby-Østergaard B, Peter Y, Romanelli M, Seppänen S, Serena TE, Sibbald G, Soriano JV, White W, Wollina U, Woo KY, Wyndham-White C, Harding KG. Dressing related pain in patients with chronic wounds: an international perspective. Int Wound J. 2008;5:159–71.

    Article  PubMed  Google Scholar 

  • Price P. The challenge of outcome measures in chronic wounds. J Wound Care. 1999;8:306–8.

    PubMed  CAS  Google Scholar 

  • Prompers L, Huijbert M, Apelqvist J, et al. Prediction of outcome in individuals with diabetes and foot ulcers: focus on the difference between individuals with and without peripheral artery disease. The EURODIALE-study. Diabetologia. 2008;51(5):747–55.

    Article  PubMed  CAS  Google Scholar 

  • Prompers L, Huijberts M, Schaper N, Apelqvist J, Bakker K, Edmonds M, Holstein P, Jude E, Jirkovska A, Mauricio D, Piaggesi A, Reike H, Spraul M, Van Acker K, Van Baal S, Van Merode F, Uccioli L, Urbancic V, Ragnarson Tennvall G. Resource utilisation and costs associated with the treatment of diabetic foot. Diabetologia. 2008;51:1826–34.

    Article  PubMed  CAS  Google Scholar 

  • Ragnarsson-Tennvall G, Apelqvist J. Cost-effective management of diabetic foot ulcers. Pharmacoeconomics. 1997;12:42–53.

    Article  Google Scholar 

  • Ryan S, Eager C, Sibbald RG. Venous leg ulcer pain. Ostomy Wound Manage. 2003;49(4 Suppl):16–23.

    PubMed  Google Scholar 

  • Sackett DL, Rosenberg WMC, Gray JAM, Haynes RB, Richardson WS. Evidence-based medicine: what is and what isn´t. BMJ. 1996;312:71–2.

    Article  PubMed  CAS  Google Scholar 

  • Vaneau M, Chaby G, Guillot B, Martel P, Senet P, Teot L, Chosidow O. Consensus panel recommendations for chronic and acute wound dressing. Arch Dermatol. 2007;143:1291–4.

    Article  PubMed  Google Scholar 

  • Wolcott RD, Rhoads DD, Bennett ME, Wolcott BM, Gogokhia L, Costerton JW, Dowd SE. Chronic wounds and the medical biofilm paradigm. J Wound Care. 2010;19:45–53.

    PubMed  CAS  Google Scholar 

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Correspondence to Finn Gottrup M.D., DMSci .

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Gottrup, F., Apelqvist, J., Price, P. (2012). Research Studies in Wound Healing: The Role of Outcomes/Endpoints for the Evidence in RCTs. In: Mani, R., Romanelli, M., Shukla, V. (eds) Measurements in Wound Healing. Springer, London. https://doi.org/10.1007/978-1-4471-2987-5_17

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  • DOI: https://doi.org/10.1007/978-1-4471-2987-5_17

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-2986-8

  • Online ISBN: 978-1-4471-2987-5

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