Abstract
Colorectal cancer is an important cancer worldwide, whose etiology is not fully understood. Known causes include several genetic factors, overweight/obesity, tobacco smoking, and heavy alcohol drinking. An etiologic role of diet is highly plausible, but the evidence for specific factors, with the possible exception of processed meat, is not conclusive. Workers exposed to asbestos have been found at increased risk of colorectal cancer in several studies, but the evidence is not sufficiently strong to conclude in favor of a causal association. No other occupational factors have been linked to colorectal cancer. Liver cancer is a common cancer in many regions of the world and is the second cause of cancer-specific mortality. About 75 % of liver cancers are hepatocellular carcinoma (HCC), the second most frequent type being cholangiocarcinoma (CCA). HCC develops in the context of a web of interactions between viral (HBV, HCV), environmental (alcohol, aflatoxin), and metabolic (fatty liver disease, obesity) factors. Genetic predisposition accounts for only a small fraction of the global burden of HCC. The only established occupational cause of liver cancer is vinyl chloride, which causes a rare type of neoplasm, angiosarcoma, and has also been associated with HCC. Detection and diagnosis of HCC are complicated by its occurrence in a background of chronic liver disease characterized by inflammation and cycles of hepatocyte proliferation and destruction. Markers used in clinical practice include serological and molecular markers of viral hepatitis, enzymatic tests for liver function and injury, and a growing list of plasma-based tumor markers, the current gold standard being alpha-fetoprotein (AFP). Recent research has identified molecular changes in transcriptome, microRNAome, epigenome, and, significantly, plasma proteome that pave the way to the development of a new generation of biomarkers for early detection of HCC in different etiologic contexts.
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Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer incidence and mortality worldwide: IARC CancerBase No. 11. Lyon: International Agency for Research on Cancer; 2013. http://globocan.iarc.fr.
Beebe-Dimer J, Schottenfeld D. Cancers of the small intestine. In: Schottenfeld D, Fraumeni JF, editors. Cancer epidemiology and prevention. New York: Oxford University Press; 2006. p. 801–8.
Forman D, Bray F, Brewster DH, et al., editors. Cancer incidence in five continents, vol. X. Lyon: International Agency for Research on Cancer; 2013. Available from: http://ci5.iarc.fr.
World Cancer Research Fund/ American Institute for Cancer Research. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Washington, DC: American Institute for Cancer Research; 2007.
International Agency for Research on Cancer. Tobacco smoke. In: IARC monographs on the evaluation of the carcinogenic risks to humans, Tobacco smoke and involuntary smoking, vol. 83. Lyon: International Agency for Research on Cancer; 2004. p. 51–1187.
Fedirko V, Tramacere I, Bagnardi V, et al. Alcohol drinking and colorectal cancer risk: an overall and dose-response meta-analysis of published studies. Ann Oncol. 2011;22:1958–72.
Giovannucci E, Wu K. Cancers of the colon and rectum. In: Schottenfeld D, Fraumeni JF, editors. Cancer epidemiology and prevention. New York: Oxford University Press; 2006. p. 809–29.
Selikoff IJ, Churg J, Hammond EC. Asbestos exposure and neoplasia. JAMA. 1964;188:22–6.
Institute of Medicine. Asbestos: selected cancers. Washington, DC: National Academy Press; 2006.
International Agency for Research on Cancer. Asbestos. In: IARC monographs on the evaluation of carcinogenic risks to humans, A review of human carcinogens, part C: arsenic, metals, fibres, and dusts, vol. 100. Lyon: International Agency for Research on Cancer; 2012. p. 219–310.
Kjarheim K, Ulvestad B, Martinsen JI, Andersen A. Cancer of the gastrointestinal tract and exposure to asbestos in drinking water among lighthouse keepers (Norway). Cancer Causes Control. 2005;16:593–8.
Thygesen LC, Albertsen K, Johansen C, Grønbaek M. Cancer incidence among Danish brewery workers. Int J Cancer. 2005;116:774–8.
Pukkala E, Martinsen JI, Lynge E, et al. Occupation and cancer – follow-up of 15 million people in five Nordic countries. Acta Oncol. 2009;48:646–790.
Theise ND, Curado MP, Franceschi S, Hytiroglou P, Kudo M, Park YN, Sakamoto M, Torbenson M, Wee A. WHO classification of tumours of the digestive system. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. Hepatocellular carcinoma. 4th ed. Lyon: International Agency for Research on Cancer; 2010. p. 205–16.
Nakanuma Y, Curado MP, Franceschi S, Gores G, Paradis V, Sripa B, Tsui WMS, Wee A. WHO classification of tumours of the digestive system. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. Intrahepatic cholangiocarcinoma. 4th ed. Lyon: International Agency for Research on Cancer; 2010. p. 217–24.
Miettinen M, Fletcher CDM, Kindblom LG, Zimmermann A, Tsui WMS. WHO classification of tumours of the digestive system. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. Mesenchymal tumours of the liver. 4th ed. Lyon: International Agency for Research on Cancer; 2010. p. 241–50.
Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int J Cancer. 2006;118:3030–44.
Mundt KA, Dell LD, Austin RP, et al. Historical cohort study of 10 109 men in the North American vinyl chloride industry, 1942–72: update of cancer mortality to 31 December 1995. Occup Environ Med. 2000;57:774–81.
Ward E, Boffetta P, Andersen A, et al. Update of the follow-up of mortality and cancer incidence among European workers employed in the vinyl chloride industry. Epidemiology. 2001;12:710–8.
Boffetta P, Matisane L, Mundt KA, Dell LD. Metaanalysis of studies of occupational exposure to vinyl chloride in relation to cancer mortality. Scand J Work Environ Health. 2003;29:220–9.
Guha N, Loomis D, Grosse Y, et al. Carcinogenicity of trichloroethylene, tetrachloroethylene, some other chlorinated solvents, and their metabolites. Lancet Oncol. 2012;13:1192–3.
Hansen J, Sallmén M, Seldén AI, et al. Risk of cancer among workers exposed to trichloroethylene: analysis of three Nordic cohort studies. J Natl Cancer Inst. 2013;105:869–77.
Vlaanderen J, Straif K, Pukkala E, et al. Occupational exposure to trichloroethylene and perchloroethylene and the risk of lymphoma, liver, and kidney cancer in four Nordic countries. Occup Environ Med. 2013;70:393–401.
Lanes SF, Rothman KJ, Dreyer NA, Soden KJ. Mortality update of cellulose fiber production workers. Scand J Work Environ Health. 1993;19:426–8.
Liu T, Xu QE, Zhang CH, Zhang P. Occupational exposure to methylene chloride and risk of cancer: a meta-analysis. Cancer Causes Control. 2013;24:2037–49.
Block JB. Angiosarcoma of the liver following vinyl chloride exposure. JAMA. 1974;229:53–4.
Laurent-Puig P, Zucman-Rossi J. Genetics of hepatocellular tumors. Oncogene. 2006;25:3778–86.
Tokino T, Tamura H, Hori N, Matsubara K. Chromosome deletions associated with hepatitis B virus integration. Virology. 1991;185:879–82.
Murakami Y, Saigo K, Takashima H, Minami M, Okanoue T, Brechot C, Paterlini-Brechot P. Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas. Gut. 2005;54:1162–8.
Tarn C, Lee S, Hu Y, Ashendel C, Andrisani OM. Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes. J Biol Chem. 2001;276:34671–80.
Feitelson MA, Sun B, Satiroglu Tufan NL, Liu J, Pan J, Lian Z. Genetic mechanisms of hepatocarcinogenesis. Oncogene. 2002;21:2593–604.
Ueda H, Ullrich SJ, Gangemi JD, Kappel CA, Ngo L, Feitelson MA, Jay G. Functional inactivation but not structural mutation of p53 causes liver cancer. Nat Genet. 1995;9:41–7.
Kim CM, Koike K, Saito I, Miyamura T, Jay G. HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature. 1991;351:317–20.
Chisari FV, Isogawa M, Wieland SF. Pathogenesis of hepatitis B virus infection. Pathol Biol (Paris). 2010;58:258–66.
Wang HC, Huang W, Lai MD, Su IJ. Hepatitis B virus pre-S mutants, endoplasmic reticulum stress and hepatocarcinogenesis. Cancer Sci. 2006;97:683–8.
Gouas D, Shi H, Hainaut P. The aflatoxin-induced TP53 mutation at codon 249 (R249S): biomarker of exposure, early detection and target for therapy. Cancer Lett. 2009;286:29–37.
Kew MC. Synergistic interaction between aflatoxin B1 and hepatitis B virus in hepatocarcinogenesis. Liver Int. 2003;23:405–9.
Umoh NJ, Lesi OA, Mendy M, Bah E, Akano A, Whittle H, Hainaut P, Kirk GD. Aetiological differences in demographical, clinical and pathological characteristics of hepatocellular carcinoma in The Gambia. Liver Int. 2011;31:215–21.
Jiang W, Wang XW, Unger T, Forgues M, Kim JW, Hussain SP, Bowman E, Spillare EA, Lipsky MM, Meck JM, Cavalli LR, Haddad BR, Harris CC. Cooperation of tumor-derived HBx mutants and p53-249(ser) mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line. Int J Cancer. 2010;127:1011–20.
Gouas DA, Shi H, Hautefeuille AH, Ortiz-Cuaran SL, Legros PC, Szymanska KJ, Galy O, Egevad LA, Abedi-Ardekani B, Wiman KG, Hantz O, de Fromentel CC, Chemin IA, Hainaut PL. Effects of the TP53 p.R249S mutant on proliferation and clonogenic properties in human hepatocellular carcinoma cell lines: interaction with hepatitis B virus X protein. Carcinogenesis. 2010;31:1475–82.
Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol. 2005;5:215–29.
Foy E, Li K, Sumpter Jr R, Loo YM, Johnson CL, Wang C, Fish PM, Yoneyama M, Fujita T, Lemon SM, Gale Jr M. Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling. Proc Natl Acad Sci U S A. 2005;102:2986–91.
Li K, Foy E, Ferreon JC, Nakamura M, Ferreon AC, Ikeda M, Ray SC, Gale Jr M, Lemon SM. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A. 2005;102:2992–7.
Majumder M, Ghosh AK, Steele R, Ray R, Ray RB. Hepatitis C virus NS5A physically associates with p53 and regulates p21/waf1 gene expression in a p53-dependent manner. J Virol. 2001;75:1401–7.
McClain CJ, Hill DB, Song Z, Deaciuc I, Barve S. Monocyte activation in alcoholic liver disease. Alcohol. 2002;27:53–61.
Hoek JB, Pastorino JG. Ethanol, oxidative stress, and cytokine-induced liver cell injury. Alcohol. 2002;27:63–8.
Lambert MP, Paliwal A, Vaissiere T, Chemin I, Zoulim F, Tommasino M, Hainaut P, Sylla B, Scoazec JY, Tost J, Herceg Z. Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake. J Hepatol. 2011;54:705–15.
Marrogi AJ, Khan MA, van Gijssel HE, Welsh JA, Rahim H, Demetris AJ, Kowdley KV, Hussain SP, Nair J, Bartsch H, Okby N, Poirier MC, Ishak KG, Harris CC. Oxidative stress and p53 mutations in the carcinogenesis of iron overload-associated hepatocellular carcinoma. J Natl Cancer Inst. 2001;93:1652–5.
Gu TL, Deng X, Huang F, Tucker M, Crosby K, Rimkunas V, Wang Y, Deng G, Zhu L, Tan Z, Hu Y, Wu C, Nardone J, MacNeill J, Ren J, Reeves C, Innocenti G, Norris B, Yuan J, Yu J, Haack H, Shen B, Peng C, Li H, Zhou X, Liu X, Rush J, Comb MJ. Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. PLoS One. 2011;6:e15640.
Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Benbrahim-Tallaa L, Guha N, Freeman C, Galichet L, Cogliano V. Group WHOIAfRoCMW. A review of human carcinogens–Part B: biological agents. Lancet Oncol. 2009;10:321–2.
Hollstein M, Marion MJ, Lehman T, Welsh J, Harris CC, Martel-Planche G, Kusters I, Montesano R. p53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers. Carcinogenesis. 1994;15:1–3.
Barbin A, Froment O, Boivin S, Marion MJ, Belpoggi F, Maltoni C, Montesano R. p53 gene mutation pattern in rat liver tumors induced by vinyl chloride. Cancer Res. 1997;57:1695–8.
Przygodzki RM, Finkelstein SD, Keohavong P, Zhu D, Bakker A, Swalsky PA, Soini Y, Ishak KG, Bennett WP. Sporadic and thorotrast-induced angiosarcomas of the liver manifest frequent and multiple point mutations in K-ras-2. Lab Invest. 1997;76:153–9.
Dragani TA. Risk of HCC: genetic heterogeneity and complex genetics. J Hepatol. 2010;52:252–7.
Jin F, Xiong WJ, Jing JC, Feng Z, Qu LS, Shen XZ. Evaluation of the association studies of single nucleotide polymorphisms and hepatocellular carcinoma: a systematic review. J Cancer Res Clin Oncol. 2011;137:1095–104.
Allen KJ, Gurrin LC, Constantine CC, Osborne NJ, Delatycki MB, Nicoll AJ, McLaren CE, Bahlo M, Nisselle AE, Vulpe CD, Anderson GJ, Southey MC, Giles GG, English DR, Hopper JL, Olynyk JK, Powell LW, Gertig DM. Iron-overload-related disease in HFE hereditary hemochromatosis. N Engl J Med. 2008;358:221–30.
Pujol FH, Navas MC, Hainaut P, Chemin I. Worldwide genetic diversity of HBV genotypes and risk of hepatocellular carcinoma. Cancer Lett. 2009;286:80–8.
Yu MW, Yeh SH, Chen PJ, Liaw YF, Lin CL, Liu CJ, Shih WL, Kao JH, Chen DS, Chen CJ. Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men. J Natl Cancer Inst. 2005;97:265–72.
Yang HI, Yeh SH, Chen PJ, Iloeje UH, Jen CL, Su J, Wang LY, Lu SN, You SL, Chen DS, Liaw YF, Chen CJ, Group R-HS. Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma. J Natl Cancer Inst. 2008;100:1134–43.
Kuang SY, Jackson PE, Wang JB, Lu PX, Munoz A, Qian GS, Kensler TW, Groopman JD. Specific mutations of hepatitis B virus in plasma predict liver cancer development. Proc Natl Acad Sci U S A. 2004;101:3575–80.
Fang ZL, Sabin CA, Dong BQ, Wei SC, Chen QY, Fang KX, Yang JY, Huang J, Wang XY, Harrison TJ. Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case-control study. J Gen Virol. 2008;89:2882–90.
Gao ZY, Li T, Wang J, Du JM, Li YJ, Li J, Lu FM, Zhuang H. Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma. J Gastroenterol. 2007;42:761–8.
Hsing AW, Rashid A, Devesa SS, Fraumeni JF. Biliary tract cancer. In: Schottenfeld D, Fraumeni JF, editors. Cancer epidemiology and prevention. New York: Oxford University Press; 2006. p. 787–800.
Malker HS, McLaughlin JK, Malker BK, et al. Biliary tract cancer and occupation in Sweden. Br J Ind Med. 1986;43:257–62.
Kuzmickiene I, Didziapetris R, Stukonis M. Cancer incidence in the workers cohort of textile manufacturing factory in Alytus, Lithuania. J Occup Environ Med. 2004;46:147–53.
Gamble J. Risk of gastrointestinal cancers from inhalation and ingestion of asbestos. Regul Toxicol Pharmacol. 2008;52(Suppl):S124–53.
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Boffetta, P., Gouas, D.A., da Costa, A.N., Abedi-Ardekani, B., Hainaut, P. (2014). Cancers of the Intestine, Liver, and Biliary Tract. In: Anttila, S., Boffetta, P. (eds) Occupational Cancers. Springer, London. https://doi.org/10.1007/978-1-4471-2825-0_6
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